Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11317-6

De novo design of enantioselective artificial metalloenzyme photocatalysts

Nature, Published online: 21 October 2026; doi:10.1038/d41586-026-03376-6

Experiment shows how these ecosystems could protect coastlines from huge storms — plus, new evidence hints at what Denisovans might have looked like.

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11252-6

Author Correction: Catalyst-free, microdroplet-mediated waste plastic conversion to diacids

Nature, Published online: 21 October 2026; doi:10.1038/d41586-026-03342-2

Physicists trap and cool down positron for months to measure its ‘magnetic moment’ with extraordinary precision.

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11096-0

Now that hyperacute rejection of pig xenografts can be reliably prevented, subtler immune-mediated graft injuries have emerged that conventional diagnostics often miss; a multimodal precision diagnostic framework is proposed to detect these injuries earlier, guide personalized immunosuppression and inform future gene editing strategies.

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11145-8

Salt marsh platforms resist erosion under extreme waves, but vegetation damage reduces wave attenuation; substantial wave attenuation by vegetation is mainly limited to low-energy marsh coasts with waves below 1 m.

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11183-2

The use of zeolites with an appropriate pore structure combined with a high CO/olefin ratio is shown to catalyse olefin carbonylation and produce primary and secondary carboxylic acids as the main products.

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11152-9

A multi-tissue signalling system links cold temperature to enhanced longevity and proteostasis in Caenorhabditis elegans.

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11188-x

Experimental and modelling data indicate that WEE1 promotes re-entry of quiescent cells into the cell cycle, potentially explaining the toxic side effects of WEE1 inhibitors in cancer therapies.

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11179-y

An environment-regulated state is identified across multiple cell types at the root tip, revealing a shared dichotomy between cells with and without this state.

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11186-z

CD51+ astrocytes promote synapse formation in the developing cortex, circuit plasticity in the hippocampus and circuit remodelling after stroke.

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11165-4

Genetic and proteomic analyses in human neurons and mouse models of Angelman syndrome (AS) show that loss of the ubiquitin ligase UBE3A leads to an overabundance of asparagine synthetase, and that this is linked with many AS phenotypes.

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11184-1

The structure of PCDH1 bound to the ANDV spike defines the structural determinants of hantavirus–receptor recognition.

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-10733-y

Proteotoxic stress drives formation of GRP75-dependent protein aggregates that signal through mitochondria–ER contact sites to activate targeted quality-control pathways, enabling selective clearance of damaged proteins and preserving mitochondrial integrity.

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11205-z

Pinal, a 16-billion-parameter artificial intelligence model, designs functional proteins from natural-language descriptions, demonstrating experimentally validated activities and improved CO2-fixation product yields without iterative optimization.

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11172-5

All-antiferromagnetic tunnel junctions can display both a large TMR and a reciprocal switching effect, octupole-driven spin-transfer torque, enabling nanoscale magnetic memory and potentially room-temperature terahertz spintronic devices.

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11168-1

Fifteen years of atmospheric CO2 measurements show that the Amazon carbon sink is weakening, with fires, deforestation and climate stress driving increasingly high carbon emissions.

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11132-z

Denisovans from the Xujiayao and other East Asian sites are morphologically distinctive, with a low cranial profile with near-parallel lateral walls, a massive supraorbital torus, a flat zygomaxillary region and weak prognathism.

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11175-2

A functional architecture of the human insula links cytoarchitecture to directed and asymmetric electrophysiological interactions, with mechanistic implications for cognitive modulation of pain and interoceptive experience.

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11194-z

Climate-driven drought and prey decline triggered lynx predation on raptors, reducing raptor fitness and abundance and producing cascading effects across lower trophic levels.