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Highly efficient base editing at <i>PCSK9</i> and normal human embryo development
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11118-x
Highly efficient base editing at PCSK9 and normal human embryo development
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Within-family effect of ancestry on complex traits in a Mexican population
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11039-9
This study uses a within-family design to identify significant ancestry differences in complex traits such as height and type 2 diabetes in a genetically diverse population from Mexico City.
Neocortical long-range inhibition promotes cortical synchrony and sleep
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10876-y
In mice, a sparse population of sleep-active long-range inhibitory neurons in the neocortex promote widespread cortical synchronization and sleep, revealing a cortical mechanism that contributes to the regulation of sleep.
PLA2G2D in tumour-draining lymph nodes regulates anti-tumour immunity
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10954-1
A specific population of macrophages that express high levels of the enzyme PLA2G2D in tumour-draining lymph nodes is associated with poor prognosis in patients, and inhibiting PLA2G2D improves anti-tumour immunity in mouse models.
Advancing conflict research and response through satellite-derived data
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11004-6
Integrating satellite-derived war-damage data with text-based fatality records through improvement, enrichment and fusion mitigates limitations inherent in each source, revealing complex violence dynamics beyond fatality-centric paradigms, as case studies from Ukraine and Myanmar illustrate.
TM184C is a GPCR-like regulator of intercellular exchange and autophagy
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10993-8
TM184C—an ancient G-protein-coupled receptor-like superdark protein involved in regulation of autophagy, intercellular connectivity and material exchange—underscores the promise of exploring the understudied human proteome and beyond.
Proximity-guided graph learning reveals tumour-associated proximity antigens
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11003-7
A proximity-mapping atlas defines tumour-associated proximity antigens, revealing disease-associated membrane spatial communities, and identifies EGFR–CDCP1 as a co-target pair that enhances tumour killing by multispecific therapeutics.
Why we need an International Panel on Inequality
Nature, Published online: 09 September 2026; doi:10.1038/d41586-026-02806-9
Disparities in income and wealth are growing. A scientific assessment process can give governments the information they need to tackle them.