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RNA synthesis and substrate analog inhibition in the CCHFV polymerase

✇Nature
By: Hengxia Jia · Bo Tang · Shunli Liu · Xin Wen · Fan Wu · Xiao Hu · Hu Zhou · Tingting Chong · Lincan Lv · Qiaojie Liu · Guibo Rao · Mingyu Wei · Xuping Jing · Sheng Cao · Fei Deng · Zhihong Hu · Bo Shu · Rui Gong · Jiqin Wu · Manli Wang · Peng Gong

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10913-w

RNA synthesis and substrate analog inhibition in the CCHFV polymerase
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Precise DNA base editing using AlphaFold3-based contact modelling

✇Nature
By: Haowei Meng · Zhixin Lei · Yongchang Yan · Liren Wang · Sihan Zhang · Xichen Rao · Chuyun Shao · Xiaoting Zhang · Ke Chen · Lei Yang · Rongrong Liu · Gaohui Yang · Ruoyu Shen · Ruichu Gu · Xinyan Wang · Yiya Wang · Suiru Lu · Zhicong Lv · Bo He · Han Wen · Dali Li · Chengqi Yi

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10794-z

ContactSeek is an AlphaFold3-driven model that can improve the precision of genome-editing tools.
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