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Modular in vivo antibody–ADC click to reverse drug resistance in tumours

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10789-w

In vivo ligation of clinically used therapeutic antibodies via bioorthogonal click chemistry to antibody–drug conjugates leads to enhanced antitumour activity in heterogeneous and treatment-resistant tumours.
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Ammonia pressure controls colloidal metal nitride synthesis in molten salts

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10801-3

A molten salt, high-pressure synthesis method enables solution-based production of diverse refractory metal nitride nanocrystals, expanding access to technologically important nitride materials for advanced applications.
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A Bayesian framework for longitudinal EHR and genetic discovery

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10780-5

A Bayesian generative framework that integrates longitudinal electronic health records with genetic data to identify latent disease signatures is presented.
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Rising dust pollution across Europe in a changing climate

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10743-w

A database of daily dust metals in Europe is established and a machine learning model shows that transported dust intrusion events over the past decade are linked to changes in atmospheric circulation, while an ice core shows that the increase in dust since pre-industrial times is governed by increasing aridity in North Africa..
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People use fast and flat simulation to reason about new games

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10722-1

Large-scale behavioural studies show that people approach a new game systematically and adaptively rationally. A cognitive model called the ‘Intuitive Gamer’ offers insights into this process and may inform the design of more flexible AI systems.
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Cell-type signatures of Alzheimer’s disease shared across population groups

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10793-0

Single-nucleus RNA-seq and ATAC-seq analyses on post-mortem brain samples from African American, Latin and white individuals identify cell-type-specific molecular signatures that are associated with cognitive impairment and/or Alzheimer’s disease across diverse population groups.
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Ketogenic diet mediates intestinal tumorigenesis through lipids not ketones

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10779-y

A combination of different manipulations in mouse models of spontaneous intestinal adenoma formation dissects the roles of systemic and epithelial ketogenesis versus dietary lipids in ketogenic diet-mediated intestinal tumorigenesis, highlighting the need for nuanced consideration of dietary strategies for cancer prevention.
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GPC3-specific dnTGFβRII-armoured CAR T cells for hepatocellular carcinoma

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10786-z

Chimeric antigen receptor (CAR) T cells for antitumour therapy ‘armoured’ with a dominant-negative TGFβ receptor II show enhanced efficacy and tolerable safety in patients with advanced hepatocellular carcinoma who have developed resistance or not responded to previous treatment.
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