❌

Reading view

Modular in vivo antibody–ADC click to reverse drug resistance in tumours

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10789-w

In vivo ligation of clinically used therapeutic antibodies via bioorthogonal click chemistry to antibody–drug conjugates leads to enhanced antitumour activity in heterogeneous and treatment-resistant tumours.
  •  

A queen odour mediates reproductive suppression in a eusocial mammal

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10772-5

Naked mole-rat (Heterocephalus glaber) queens produce isopropyl myristate, a low-volatility ester that high-ranking animals detect and avoid, which alters prolactin and progesterone in other females to suppress reproduction and preserve eusocial hierarchy.
  •  

Highly fragmented European wetlands with uneven restoration needs

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10760-9

Satellite imagery and machine learning used for the mapping of six seminatural open wetland types and land-use disturbance in European countries shows that wetlands are highly fragmented and have uneven restoration needs.
  •  

Universal gates from braiding and fusing anyons on quantum hardware

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10709-y

A 54-qubit realization of non-Abelian S3 topological order demonstrates that combining anyon braiding with fusion enables universal topological quantum computation.
  •  

Quantum statistical plasmonic metacrystals

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10782-3

A new class of materials, quantum statistical plasmonic metacrystals, is described, which can selectively transmit different types of light based only on their quantum coherence, showing bands of allowed and forbidden photon statistics.
  •  

A Bayesian framework for longitudinal EHR and genetic discovery

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10780-5

A Bayesian generative framework that integrates longitudinal electronic health records with genetic data to identify latent disease signatures is presented.
  •  

Regression to the mean can explain saturation of geomagnetic storms

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10757-4

The saturation of geomagnetic activity with solar wind strength can be explained by a regression to the mean effect, suggesting that the impact of extreme geomagnetic storms can be twice as large as previously thought
  •  

Metabolite glues as a means of purine sensing and chemotherapeutic response

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10790-3

Purines can act as endogenous molecular glues in human cells by anchoring a rate-limiting enzyme in purine biosynthesis to its inhibitor, and modifying this mechanism could provide a way to improve the properties of thiopurine chemotherapeutic drugs.
  •  

Rising dust pollution across Europe in a changing climate

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10743-w

A database of daily dust metals in Europe is established and a machine learning model shows that transported dust intrusion events over the past decade are linked to changes in atmospheric circulation, while an ice core shows that the increase in dust since pre-industrial times is governed by increasing aridity in North Africa..
  •  

People use fast and flat simulation to reason about new games

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10722-1

Large-scale behavioural studies show that people approach a new game systematically and adaptively rationally. A cognitive model called the ‘Intuitive Gamer’ offers insights into this process and may inform the design of more flexible AI systems.
  •  

Cell-type signatures of Alzheimer’s disease shared across population groups

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10793-0

Single-nucleus RNA-seq and ATAC-seq analyses on post-mortem brain samples from African American, Latin and white individuals identify cell-type-specific molecular signatures that are associated with cognitive impairment and/or Alzheimer’s disease across diverse population groups.
  •  

Ketogenic diet mediates intestinal tumorigenesis through lipids not ketones

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10779-y

A combination of different manipulations in mouse models of spontaneous intestinal adenoma formation dissects the roles of systemic and epithelial ketogenesis versus dietary lipids in ketogenic diet-mediated intestinal tumorigenesis, highlighting the need for nuanced consideration of dietary strategies for cancer prevention.
  •  

Fractional high-Chern insulator in twisted rhombohedral graphene

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10762-7

A rich variety of both integer and fractional high-Chern insulators are observed in a moiré system composed of Bernal bilayer graphene and rhombohedral tetralayer graphene.
  •  

GPC3-specific dnTGFβRII-armoured CAR T cells for hepatocellular carcinoma

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10786-z

Chimeric antigen receptor (CAR) T cells for antitumour therapy ‘armoured’ with a dominant-negative TGFβ receptor II show enhanced efficacy and tolerable safety in patients with advanced hepatocellular carcinoma who have developed resistance or not responded to previous treatment.
  •  

Catalyst-free, microdroplet-mediated waste plastic conversion to diacids

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10746-7

A catalyst-free upcycling strategy based on in situ generation of hydroxyl radicals at microdroplet interfaces is described for efficient and scalable processing of polymers with minimal infrastructure, using only water and oxygen under mild conditions.
  •  
❌