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Towards Conversational AI for Disease Management
Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10764-5
Towards Conversational AI for Disease Management
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A distant brown dwarf coplanar to a warm Jupiter and a hot super-Earth
Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10586-5
Analysis of long-term radial velocity data and transit time variations, induced by a super-Earth, a warm Jupiter and a brown dwarf in a coplanar orbit around the relatively young star TOI201.
Probing picometre-scale interlayer deformations via hyperbolic polaritons
Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10638-w
A new polaritonic optical method that uses the mid-infrared out-of-plane hyperbolic polaritons mode is described and experimentally validated to allow the examination of picometre-scale interlayer deformations, providing a bridge between nanomechanics and photonics.
A prototype differential atom interferometer for fundamental physics
Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10617-1
A prototype differential atom interferometer operates at the standard quantum limit with no excess noise beyond atom shot noise, achieving performance in line with the specifications for future long-baseline atom interferometers.
Structure of the pre-initiation complex explains CMGE biogenesis
Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10657-7
Cryo-electron microscopy and biochemical reconstitution experiments in yeast provide insight into the assembly of the CMGE complex, a helicase that establishes bidirectional DNA replication in eukaryotic cells, and elucidate the role of the firing factor Sld2.
A 98-qubit trapped-ion quantum computer with all-to-all connectivity
Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10676-4
A new quantum computer, Quantinuum Helios, which is a 98-qubit trapped-ion quantum processor built on the QCCD architecture, demonstrates performance well beyond classical capabilities and provides a path for scaling up quantum computing.
Molecular basis of polyadenylated RNA fate determination in the nucleus
Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10650-0
Biochemical, structural and cell biological analyses reveal that UAP56 (DDX39B) assembles with a TREX-2–like module that redirects non-functional polyadenylated RNAs from export to degradation.
Rock weathering can counteract river CO<sub>2</sub> emissions induced by permafrost thaw
Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10664-8
Permafrost thaw on the Qinghai–Tibet Plateau increases rock-weathering rates while reducing river CO2 emissions, suggesting geological carbon fluxes may eventually outpace thaw-driven emissions.
Cortical development dynamics across autism spectrum disorder mouse models
Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10679-1
Using single-nucleus multi-omic sequencing, diverse autism spectrum disorder-linked gene mutations converge on transient, stage-specific disruptions in early brain development, and highlight sex-specific gene expression alterations.
A mosaic of whole-body representations on the human precentral gyrus
Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10653-x
A comprehensive map of the human motor cortex at single-neuron resolution is described.
Mapping the neuronal building blocks of human language with language models
Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10691-5
Wide-scale recordings reveal neurons in the human brain that encode fundamental components of language such as the grammatical relationships between words, their parts of speech and the higher-order syntactic structure of phrases and sentences.
Towards autonomous medical artificial intelligence agents
Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10675-5
A large language model artificial intelligence agent operating in a sandboxed electronic health record system can autonomously take patient histories, order tests, interpret findings, diagnose conditions and propose treatments, outperforming experienced clinicians while adhering to safety standards and clinical guidelines.