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RNA synthesis and substrate analog inhibition in the CCHFV polymerase

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10913-w

RNA synthesis and substrate analog inhibition in the CCHFV polymerase
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Structures and inhibition of the Crimean–Congo haemorrhagic fever virus polymerase

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10701-6

Structural studies of Crimean–Congo haemorrhagic fever virus (CCHFV) polymerase reveal the structural basis of CCHFV RNA synthesis and highlight druggable sites for designing both nucleoside antivirals and non-nucleoside antivirals.
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Non-epitaxial perovskite polariton laser diode operating under direct current

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10824-w

By integrating a solution-grown perovskite microplate with chemically inert single-walled carbon nanotube electrodes and embedding them into an optical microcavity, the new microdevices can achieve polariton lasing under a constant direct current at 8 K.
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Prior therapy defines mutation profiles in childhood cancer at relapse

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10803-1

Chemotherapy, particularly with platinum-based drugs, is associated with substantial, rapidly detectable mutagenesis in childhood cancers, tripling private signatures and doubling mutation burden, highlighting therapy-induced tumour evolution and opportunities for safer, de-escalated treatment.
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Structural basis of the RNA-editing cascade in trypanosome mitochondria

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10831-x

Cryo-electron microscopy sheds light on the architecture of the Trypanosoma brucei mitochondrial editosome and reveals how this assembly mediates mRNA editing through the insertion and deletion of uridine nucleotides.
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Insulator-free topological photonic multi-lane highways

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10817-9

An insulator-free topological waveguide architecture comprising four inequivalent photonic valley half-semimetals arranged in a parallel, cyclic configuration and stacked very close to one another demonstrates robust, multi-lane, unidirectional light transport with 100% spatial efficiency.
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Planetary-mass exosatellite detected around the substellar companion of a star

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10751-w

Radial velocity measurements provide evidence for a Jupiter-mass exosatellite orbiting the brown dwarf companion CD-35 2722 B, a promising detection of an exomoon-like object.
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Tertiary lymphoid structures harbour stem-like tumour-specific T cells

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10808-w

Renal cell carcinoma tumours containing tertiary lymphoid structures (TLSs) are enriched for exhausted CD8+ T cells, including tumour-specific clonotypes with stem-like progenitor features and reduced terminal exhaustion.
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A vector-based strategy for olfactory navigation in <i>Drosophila</i>

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10827-7

Using a virtual reality system, experiments in Drosophila show that flies use memory mechanisms to navigate along the boundary of an odour plume and track the source of a smell.
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Precise DNA base editing using AlphaFold3-based contact modelling

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10794-z

ContactSeek is an AlphaFold3-driven model that can improve the precision of genome-editing tools.
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AI-redesigned starting points and outcomes enhance protein evolution

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10820-0

A workflow using artificial intelligence-redesigned starting points to evolve enzymes with improved properties compared with those evolved from natural proteins is established.
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The planktonic microbiome of the Great Barrier Reef

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10778-z

The Great Barrier Reef Microbial Genomes Database compiles prokaryotic, viral and eukaryotic genomes from seawater collected from the Great Barrier Reef, providing a rich resource for the study of marine microbial communities and ecosystem research and management.
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A global molecular code for birth order and neuronal identity in <i>Drosophila</i>

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10797-w

A high-resolution developmental transcriptional atlas of the Drosophila melanogaster nerve cord identifies a shared transcriptional code that records neuronal birth order and organizes neuronal diversity.
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