Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-10733-y

Proteotoxic stress drives formation of GRP75-dependent protein aggregates that signal through mitochondria–ER contact sites to activate targeted quality-control pathways, enabling selective clearance of damaged proteins and preserving mitochondrial integrity.

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11126-x

The AI framework probabilistic bias correction is shown to correct weather forecast errors 2 to 6 weeks ahead and boost forecast skill, making it promising for improved extreme-weather prediction.