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Octahedral-coordinated Co<sub>3</sub>O<sub>4</sub> for water electrolysis in acid

By: Yue Wang · Yujin Ji · Jing Zhou · Jinxin Chen · Chenchen Li · Chendi Zhao · Jia Ke · Yutian Xiong · Sihui Pan · Wei-Hsiang Huang · Chih-Wen Pao · Chang-Yang Kuo · Chien-Te Chen · Youyong Li · Zhiwei Hu · Qi Shao · Xiaoqing Huang

29 July 2026 at 01:00

Nature, Published online: 29 July 2026; doi:10.1038/s41586-026-10851-7

A new trigonal-phase Co3O4 manufactured using a vacuum-mediated molten-alkali mechanochemical method is described, demonstrating edge-shared octahedral coordination and achieving lower overpotential than spinel-type Co3O4 in the acidic oxygen evolution reaction, with reduced dissolution of cobalt.

A first-in-class pulsatile FXR agonist for bile-acid-related liver diseases

Nature

By: Yi Zang · Jingjing Shi · Guanguan Zhao · Bixi Tang · Mingliang Liu · Benqiang Yao · Gaihong Wang · Hualing Pan · Shengsheng Yang · Rong Deng · Yishuang Zhao · Zhenwei Zhang · Hao-Ran Guo · Dan-Dan Sun · Hanlin Wang · Lixin Gao · Jinghua Yu · Xingxing Diao · Yong Li · Jia Li · H. Eric Xu

10 June 2026 at 01:00

Nature, Published online: 10 June 2026; doi:10.1038/s41586-026-10633-1

Linafexor is a rapidly cleared FXR agonist designed to mimic natural bile acid signalling, achieving transient receptor activation with strong efficacy and reduced toxicity in preclinical and early clinical studies.