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Intestinal stem cells count self-renewal divisions to switch multipotency

Nature, Published online: 29 July 2026; doi:10.1038/s41586-026-10814-y

In Drosophila, cell fate switching in adult intestinal stem cells is determined through an epigenetic mechanism in which these cells count divisions, switching from producing enterocytes to producing an enteroendocrine mother cell every ninth division.
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Programming fracture resistance in metamaterials via elastic instabilities

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10804-0

Elastic instabilities in mechanical metamaterials can be harnessed to programme fracture behaviour, transforming instability from a failure mechanism into a design principle that increases fracture energy by up to tenfold.
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Air-permeable hydrogels through viscoelastic phase separation of aerogels

Nature, Published online: 08 July 2026; doi:10.1038/s41586-026-10712-3

Viscoelastic phase separation is used to fabricate non-collapsible, air-rich networks in high-water-content hydrogels containing silica aerogel beads, allowing air to permeate through the material and enabling a tenfold increase in oxygen permeability over pristine hydrogels.
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Efficient and accurate neural-field reconstruction using resistive memory

Nature, Published online: 10 June 2026; doi:10.1038/s41586-026-10646-w

A co-optimized AI hardware–software system using resistive-memory computing improves energy efficiency and parallelism for sparse signal reconstruction in imaging and three-dimensional vision applications.
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