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Sequential reading of a stepwise-shortened peptide immobilized on nanopore

By: Jialu Chen · Hanhan Zhang · Kefan Wang · Tian Li · Wen Sun · Zixuan Wang · Xinmeng Gao · Zhenyuan Cao · Yusheng Ouyang · Lang Yao · Yifan Wang · Yunqi Xiao · Ruidong Li · Xingwang An · Xinyi Dai · Lulu Zhao · Lu Qian · Panke Zhang · Shuo Huang

29 July 2026 at 01:00

Nature, Published online: 29 July 2026; doi:10.1038/s41586-026-10881-1

A nanopore-based ‘chop and measure’ method sequences peptides at single-amino-acid resolution by using enzymatic digestion to progressively shorten the N terminus one residue at a time, together with repetitive N-terminus re-reading.

Efficient and precise programmable DNA knock-in without double-strand breaks

Nature

By: Yanmin Gao · Yu Ma · Kexin Yu · Yintian Liu · Buming Gu · Hao Tang · Wenjie Yan · Shuangshuang Yang · Jingran Su · Xindong Wang · Xin Ma · Xinming Wang · Fang Wang · Qingyang Li · Mengying Liu · Haifeng Wang

22 July 2026 at 01:00

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10819-7

Kilobase-scale nickase-targeting (KNIT) editing enables single-nick-based DNA insertion across genomic loci and cell types, supporting insertion of DNA fragments exceeding 10 kb, with high efficiency and minimal unwanted off-target effects.