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Programmable design of functional proteins from natural language

By: Fengyuan Dai · Shiyang You · Yudian Zhu · Yuan Gao · Lihao Fu · Xibin Zhou · Jin Su · Chentong Wang · Yuliang Fan · Qingsong Tan · Xiaoxiao Ma · Xianjun Deng · Letong Yu · Hui Qian · Yan He · Yitao Ke · Zhe Zhang · Chenchen Han · Xing Chang · Liangzhen Zheng · Sheng Wang · Yuan Ji · Kexin Hao · Longxing Cao · Yajie Wang · Anping Zeng · Shunzhi Wang · Chunjun Zhan · Jing Zhao · Tong Si · Jianming Liu · Hongyuan Lu · Fajie Yuan

21 October 2026 at 01:00

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11205-z

Pinal, a 16-billion-parameter artificial intelligence model, designs functional proteins from natural-language descriptions, demonstrating experimentally validated activities and improved CO2-fixation product yields without iterative optimization.

Structural basis of the RNA-editing cascade in trypanosome mitochondria

Nature

By: Yun-Tao Liu · Andres F. Vacas · Jonathan Jih · Xiaojing Zhao · Clinton Yu · Jane K. J. Lee · Takuma Suematsu · Md Solayman · Hong Wang · Xiaorong Wang · Lan Huang · Liye Zhang · Inna Aphasizheva · Z. Hong Zhou · Ruslan Aphasizhev

22 July 2026 at 01:00

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10831-x

Cryo-electron microscopy sheds light on the architecture of the Trypanosoma brucei mitochondrial editosome and reveals how this assembly mediates mRNA editing through the insertion and deletion of uridine nucleotides.