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Precise DNA base editing using AlphaFold3-based contact modelling

✇Nature
By: Haowei Meng · Zhixin Lei · Yongchang Yan · Liren Wang · Sihan Zhang · Xichen Rao · Chuyun Shao · Xiaoting Zhang · Ke Chen · Lei Yang · Rongrong Liu · Gaohui Yang · Ruoyu Shen · Ruichu Gu · Xinyan Wang · Yiya Wang · Suiru Lu · Zhicong Lv · Bo He · Han Wen · Dali Li · Chengqi Yi

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10794-z

ContactSeek is an AlphaFold3-driven model that can improve the precision of genome-editing tools.
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Spatial distribution of the proteome in the human body and in cancers

✇Nature
By: Liang Yue · Wenhao Jiang · Sainan Li · Meng Luo · Ning Fan · Xiaolu Zhan · Rui Sun · Honghan Cheng · Zhangzhi Xue · Tong Liu · Qianhe Zhou · Kexin Chen · Tian Lu · Fang Guo · Dongwei Li · Weigang Ge · Zongxiang Nie · Mengge Lyu · Jun A · Yingrui Wang · Yingdan Chen · Zhenhai Fu · Nan Xiang · Lu Li · Fengchao Yu · Guo Ci Teo · Alexey I. Nesvizhskii · Meng Wang · Michael P. Snyder · Ben C. Collins · Qi Xiao · Ruedi Aebersold · Fei Xu · Hui Yang · Sijia Zhang · Yi Han · Yi Zhu · Yong Ji · Yan Li · Tiannan Guo

Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10660-y

A spatially resolved map of the human proteome across a variety of healthy tissues and cancers provides wide-ranging insights in developmental biology and oncology, and could aid the identification of therapeutic targets and development of treatments for cancer.
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