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An operational perturbation proteomics-based virtual cell model

✇Nature
By: Rui Sun · Liujia Qian · Yongge Li · Tong Liu · Honghan Cheng · Xuedong Zhang · Xueya Zhou · Yuecheng Zhan · Guangmei Zhang · Zhengchao Luo · Kunpeng Ma · Chunlong Wu · Dongchen Ji · Zhangzhi Xue · Hongxue Meng · Yuhang Xiang · Dingwei Lei · Qianhe Zhou · Wenbin Hu · Yuhan Deng · Lingling Tan · Qi Xiao · Zhiwei Liu · Lei Zeng · Liqin Qian · Xuan Zheng · Qiong Hu · Nianzi Luo · Weinan E · Peijie Zhou · Han Wen · Yi Zhu · Tiannan Guo

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11001-9

Temporal protein-abundance measurements from systematically perturbed breast cancer cell lines were generated to develop ProteinTalks, a virtual cell model that functions as an operational tool for diverse drug discovery tasks.
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Spatial distribution of the proteome in the human body and in cancers

✇Nature
By: Liang Yue · Wenhao Jiang · Sainan Li · Meng Luo · Ning Fan · Xiaolu Zhan · Rui Sun · Honghan Cheng · Zhangzhi Xue · Tong Liu · Qianhe Zhou · Kexin Chen · Tian Lu · Fang Guo · Dongwei Li · Weigang Ge · Zongxiang Nie · Mengge Lyu · Jun A · Yingrui Wang · Yingdan Chen · Zhenhai Fu · Nan Xiang · Lu Li · Fengchao Yu · Guo Ci Teo · Alexey I. Nesvizhskii · Meng Wang · Michael P. Snyder · Ben C. Collins · Qi Xiao · Ruedi Aebersold · Fei Xu · Hui Yang · Sijia Zhang · Yi Han · Yi Zhu · Yong Ji · Yan Li · Tiannan Guo

Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10660-y

A spatially resolved map of the human proteome across a variety of healthy tissues and cancers provides wide-ranging insights in developmental biology and oncology, and could aid the identification of therapeutic targets and development of treatments for cancer.
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