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Amygdala astrocyte primary cilium mechanisms contribute to stress behaviours

✇Nature
By: Sara G. Pelaz · Katsukuni Mitsui · Natalia Kolosowska · Haley Fritch · Chiranjivi Neupane · Vanessa H. Casha · Marta Alonso-Gardón · Vijaya Pandey · Lizheng Wang · Riki Kawaguchi · James A. Wohlschlegel · Jiami Guo · Steven A. McCarroll · Sabina Berretta · Baljit S. Khakh

Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10874-0

Amygdala astrocyte primary cilia are disrupted during stress, and their restoration leads to improvements in stress-related behaviour in mice.
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Antigen presentation by CD40<sup>+</sup>MHC-II<sup>+</sup> astrocytes promotes CNS autoimmunity

✇Nature
By: Joon-Hyuk Lee · Zhaorong Li · Joselyn S. Soto · Ah-Ram Kim · Tomer Illouz · Carolina M. Polonio · Michael Kilian · Jessica E. Kenison · Anton M. Schüle · Camilo Faust Akl · Hong-Gyun Lee · Brian M. Andersen · Jessica J. Ye · Joseph M. Rone · Gavin Piester · Lena Srun · Jazmin Martinez · Austin Danko · Jinsu Lee · Tae Hyun Heo · Elizabeth N. Chung · Landon K. Oetjen · Pere Duart-Abadia · Nakyung Koo · Norbert Perrimon · Michael A. Wheeler · Baljit S. Khakh · Stephanie E. J. Zandee · Alexandre Prat · Francisco J. Quintana

Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10860-6

Astrocytes promote central nervous system (CNS) immunity through antigen presentation and activation of CD40 in astrocytes by CD40L expressed by CD4+ T cells in a model of experimental autoimmune encephalomyelitis.
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