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Semaglutide fuels rapid growth in US GLP-1RA use as payments rise

Nationally representative US data show GLP-1RA use rose 230% among adults with diabetes and 643% among those without reported diabetes between 2017 and 2022, largely driven by semaglutide. Mean annual out-of-pocket payments decreased, but mean total annual payments per user increased, raising concerns about long-term affordability.

Semaglutide fuels rapid growth in US GLP-1RA use as payments rise
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Gut microbial metabolites may shape vulnerability to stress-related mental disorders

Gut microbiome-derived metabolites may influence stress-related mental disorders through neural, immune, endocrine, and epigenetic pathways. Evidence is strongest for depression and preclinical models, while larger longitudinal human studies are needed to establish causality and clinical value.

Gut microbial metabolites may shape vulnerability to stress-related mental disorders
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Missing ancestry data in single-cell atlases threatens fair medicine

The single-cell "atlases" that are increasingly used to map the human body and as training data for artificial intelligence models, may not represent the world's populations fairly, according to a study led by researchers at the Icahn School of Medicine at Mount Sinai.

Missing ancestry data in single-cell atlases threatens fair medicine
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E-bike injuries rise dramatically across California in recent years

Researchers from University of California San Diego have found that injuries involving electric bicycles, or e-bikes, have increased dramatically across California, rising from just two reported collisions in 2018 to 1,506 in 2024.

E-bike injuries rise dramatically across California in recent years
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Prenatal use of certain medications can harm developing fetal brain

A review article by a University of Nebraska Medical Center/Child Health Research Institute research team underscores and describes how altering fundamental brain development processes can be detrimental for the developing baby.

Prenatal use of certain medications can harm developing fetal brain
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Study shows how stress forces brain to prioritize memories

The brain is the machine that perceives, analyses, sorts, stores and prioritizes our memories. However, not all experiences and perceptions are stored in the same way, and not everything is remembered equally, especially when under pressure or emotional stress.

Study shows how stress forces brain to prioritize memories
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WHO updates guidelines to reduce risk of dementia worldwide

The World Health Organization (WHO) today released updated guidelines on reducing the risk of cognitive decline and dementia, providing countries with evidence-based recommendations to help prevent or delay the onset of dementia across the life course.

WHO updates guidelines to reduce risk of dementia worldwide
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