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Global genetic interaction network of a human cell maps conserved principles and informs functional interpretation of gene co-essentiality profiles

Publication date: 11 June 2026

Source: Cell, Volume 189, Issue 12

Author(s): Maximilian Billmann, Michael Costanzo, Xiang Zhang, Arshia Z. Hassan, Mahfuzur Rahman, Kevin R. Brown, Katherine S. Chan, Amy Hin Yan Tong, Carles Pons, Henry N. Ward, Catherine Ross, Jolanda van Leeuwen, Michael Aregger, Keith A. Lawson, Barbara Mair, Amy F. Roth, Nesli E. Sen, Duncan T. Forster, Guihong Tan, Patricia Mero

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Somatic cancer variants enriched in Alzheimer’s disease microglia-like cells drive inflammatory and proliferative states

Publication date: 11 June 2026

Source: Cell, Volume 189, Issue 12

Author(s): August Yue Huang, Zinan Zhou, Maya Talukdar, Liz Enyenihi, Michael B. Miller, Brian Chhouk, Ila Rosen, Mengyue Zheng, Minye Zhou, Averill Yang, Edward Stronge, Madel Durens, Minh Nguyen, Jaejoon Choi, Boxun Zhao, Sattar Khoshkhoo, Junho Kim, Rebecca Andersen, Zheming An, Yuchen Cheng

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A 3D morphogenetic blueprint for metastatic outgrowth in breast cancer

Publication date: 11 June 2026

Source: Cell, Volume 189, Issue 12

Author(s): Robin Caire, Roberta Bordo, Francesca Zanconato, Tito Panciera, Estelle Audoux, Paolo Contessotto, Michaela Fakiola, Ramona Bason, Oriana Romano, Ambela Suli, Giusy Battilana, Matteo Marchionni, Mattia Forcato, Sara Donzelli, Maria Vittoria Dieci, Gaia Griguolo, Mariantonia Carosi, Matteo Fassan, Vincenza Guzzardo, Angelo Paolo Dei Tos

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Sulfur partitioning from cysteine controls T cell proliferation and effector function

Publication date: 11 June 2026

Source: Cell, Volume 189, Issue 12

Author(s): Beth Kelly, Minsun Cha, Tatjana Gremelspacher, Jacob L. Martin, Massimo Andreis, Isha Maloo, Gustavo E. Carrizo, Mia Gidley, Michal A. Stanczak, Petya Apostolova, Joseph Longo, Lisa M. DeCamp, Eric H. Ma, Ryan D. Sheldon, Russell G. Jones, David E. Sanin, Ananya Majumdar, Erika L. Pearce

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Systematic discovery of pro- and anti-HIV host factors in primary human CD4+ T cells

Publication date: 11 June 2026

Source: Cell, Volume 189, Issue 12

Author(s): Ujjwal Rathore, Eli Dugan, Hunter Thornton, Vigneshwari Easwar Kumar, Rama Dajani, Ryan C. Burdick, Janet M. Young, Zachary Steinhart, Reanna Lao, Krista A. Delviks-Frankenberry, Wooyoung Choi, William S. Henriques, Ignacia Echeverria, Emma Dann, Ishaan Dureja, Nandini Pathak, Maya M. Arce, Justin McKetney, Jennifer M. Umhoefer, Simrun Parulekar

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Sensing endoplasmic reticulum redox state by ethylene receptors

Publication date: 11 June 2026

Source: Cell, Volume 189, Issue 12

Author(s): Dongdong Hao, Zhina Xiao, Wei Yan, Chenliang Pan, Yanting Yang, Wen Song, Zhiren Chen, Ying Xing, Lian Jin, Yang Peng, Yuping Qiu, Kai Jiang, Xing Wen, Kai Huang, Shi Xiao, Haodong Chen, Hongwei Guo

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Stabilizing MARCH7 as a ferro-guardian against ferroptosis

Publication date: 11 June 2026

Source: Cell, Volume 189, Issue 12

Author(s): Wenxiang Huang, Ruijun Wang, Xinquan Yang, Shuangjie Yang, Xueliang Yang, Gaolu He, Songjun Dai, Caizhi Li, Lianchao Gao, Tingting Zhang, Peng Zhang, Ruihan Chen, Keke Zheng, Junbing Wu, Junxia Min, Qian Ba, Fudi Wang, Qiang Zhang

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Nuclear proteome reveals microtubule-associated protein regulating fate and disease

Publication date: 6 August 2026

Source: Cell, Volume 189, Issue 16

Author(s): Florencia Merino, Lucas Miranda, Aparajita Kumar, Yiling Li, Deepak Kumar Sundaramoorthy, Juliane Merl-Pham, Eva-Maria Schentarra, Clemens Steinek, Veronica Pravata, Claire Kittock, Martina BΓΌrkle, Bob A. Hersbach, Javier Ferri Beneito, Florian Giesert, Ralf Jungmann, Louis-Jan Pilaz, Stefanie M. Hauck, Silvia Cappello, Magdalena GΓΆtz

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