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GRP75-dependent SIMPA mediates inter-organellar quality control

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-10733-y

Proteotoxic stress drives formation of GRP75-dependent protein aggregates that signal through mitochondria–ER contact sites to activate targeted quality-control pathways, enabling selective clearance of damaged proteins and preserving mitochondrial integrity.
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Suppressing the interface electric field fluctuation through faceto-face electronic channel regulation for sustainable zinc batteries

Energy Environ. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6EE02798A, Paper
Fusheng Luo, Song Yang, Qing Wu, Jinlong Zhang, Zeyu Yan, Xiude Liu, Jun Huang, Yiwang Chen
The poor electrode-electrolyte interface interaction, which originated from the limited interfacial contact and uneven charge aggregation, represent the primary constraints for the practical application of gel electrolytes in aqueous zinc...
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