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David Agus’s first encounter with Elizabeth Holmes at a health conference came as a shock. The Holmes he met in the green room was personable and pleasant. The Holmes he interviewed on stage was altogether different.

“The accent changed: this deep voice, very serious,” Agus, a medical oncologist, recalls by phone from Los Angeles. “It was as if I had met a person and then interviewed a separate person. That transition from the green room to the stage – I had never experienced something like that before.”