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Received — 17 October 2026 ⏭

Nature
Structural basis of ligand recognition and gating in mosquito IRs 14 October 2026 at 01:00

Structural basis of ligand recognition and gating in mosquito IRs

By: Li Xu · Xin Wang · Xuebo Quan · Stephen T. Ferguson · Dong Liu · Jiawei Chen · Sai Wang · Simin Liang · Gaoxingyu Huang · Kai Huang · Feng Liu · Xiaojing Pan

14 October 2026 at 01:00

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11239-3

Structural basis of ligand recognition and gating in mosquito IRs

Nature
Engineered TYK2 dependence enables myeloid-selective IL-10 receptor agonism 14 October 2026 at 01:00

Engineered TYK2 dependence enables myeloid-selective IL-10 receptor agonism

Nature

By: D. Alejandro Canaria · Trang T. T. Nguyen · Huang Huang · Hui Xu · Lili Yue · Yongyao Fu · Hoa Truong · Kerul Patel · Weimei Xing · Jayamary Divya Ravichandar · Cong Xing · Aron L. Martin · George Delidakis · Sylvia Wong · Andrew Pae · Yu Yu · Ramsay Macdonald · Zhiyu Huang · Meagan C. Main · Amanali Rodriguez · Xiaoli Lin · Maria L. Mouchess · Magdeleine Hung · Ellen M. McGlinchey · Lei Chen · Nicole Schirle Oakdale · Brian Carr · Megan L. Koleske · Chingwei V. Lee · Chen Chen · Tangsheng Yi

14 October 2026 at 01:00

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11176-1

A tetravalent nanobody-based myeloid-selective IL-10 receptor agonist recapitulates IL-10’s potent suppression of monocytes, macrophages and dendritic cells while avoiding stimulation of T cells.