Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11065-7

The mechanical properties of medium-entropy alloys at 20 K show a plateau in tensile yield strength and fracture toughness as a function of temperature, with no apparent ductile-to-brittle transition.

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11143-w

De novo-designed enzymes use an activated cysteine nucleophile to hydrolyse polypeptide backbones in a sequence-dependent manner.

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11167-2

RFdiffusion methods are used to de novo design proteins with water-activating zinc-based active sites adjacent to a peptide substrate binding pocket, yielding highly active, programmable proteases with potential applications in therapeutics, biotechnology and bioremediation.