In recent years, there has been a lot of excitement about the potential for studying human diseases in what are called "organoids." These small patches of tissue, formed using stem cells, appear to produce many of the same cell types and at least some of the structures normally formed in actual organs, and thus can provide a better model for diseases that rely on the sometimes complex interactions among multiple specialized cell types that are a feature of the human body.

But even the most sophisticated organoids lack a lot of the features of a real human body. This is especially true for brain organoids, which don't form any of the connections with specialized brain structures needed to behave "normally." On Wednesday, a research group at Stanford University described a possible way to study brain organoids in a somewhat more natural context: They genetically wiped out a large portion of the mouse brain and replaced it with human brain organoid cells.

The replacements

Organoids, because they adopt a three-dimensional tissue structure and consist of various specialized cells, provide a much better model for an intact tissue than simply having a bunch of disassociated cells lying flat on a culture dish. But they still have a lot of limitations—they're not hooked up to a circulatory system that allows the liver to process chemicals the organoid produces and don't have immune cells moving through them, to give just a couple of examples.

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In recent years, there has been a lot of excitement about the potential for studying human diseases in what are called "organoids." These small patches of tissue, formed using stem cells, appear to produce many of the same cell types and at least some of the structures normally formed in actual organs, and thus can provide a better model for diseases that rely on the sometimes complex interactions among multiple specialized cell types that are a feature of the human body.

But even the most sophisticated organoids lack a lot of the features of a real human body. This is especially true for brain organoids, which don't form any of the connections with specialized brain structures needed to behave "normally." On Wednesday, a research group at Stanford University described a possible way to study brain organoids in a somewhat more natural context: They genetically wiped out a large portion of the mouse brain and replaced it with human brain organoid cells.

The replacements

Organoids, because they adopt a three-dimensional tissue structure and consist of various specialized cells, provide a much better model for an intact tissue than simply having a bunch of disassociated cells lying flat on a culture dish. But they still have a lot of limitations—they're not hooked up to a circulatory system that allows the liver to process chemicals the organoid produces and don't have immune cells moving through them, to give just a couple of examples.

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Our basic understanding of core-collapse supernovae hasn't changed in decades. Large stars burn through all the fuel at their cores and start creating heavier elements in reactions that consume energy. The lack of energy from these reactions allows gravity to pull the interior of the star in on itself, collapsing it into a neutron star or black hole. The energy released by this process then blows the remainder of the star apart.

And, generally, that's right. But there's an entire busload of devils in the details. The statistics of supernovae that we've observed indicate that the model may be seriously incomplete. And on the theoretical side, there are still plenty of uncertainties, including over some of the basics, such as whether all core collapses actually result in a supernova.

A paper being released by Physical Review D provides what might be a potential explanation for the discrepancy: flavor-changing neutrinos. Neutrinos play a key role in our current models of supernovae, and right now, those models don't take into account one of neutrinos' most striking features: their ability to change identity.

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Our basic understanding of core-collapse supernovae hasn't changed in decades. Large stars burn through all the fuel at their cores and start creating heavier elements in reactions that consume energy. The lack of energy from these reactions allows gravity to pull the interior of the star in on itself, collapsing it into a neutron star or black hole. The energy released by this process then blows the remainder of the star apart.

And, generally, that's right. But there's an entire busload of devils in the details. The statistics of supernovae that we've observed indicate that the model may be seriously incomplete. And on the theoretical side, there are still plenty of uncertainties, including over some of the basics, such as whether all core collapses actually result in a supernova.

A paper being released by Physical Review D provides what might be a potential explanation for the discrepancy: flavor-changing neutrinos. Neutrinos play a key role in our current models of supernovae, and right now, those models don't take into account one of neutrinos' most striking features: their ability to change identity.

Read full article

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