Biofilms are complex microbial communities that adhere to a surface and encase themselves in a viscous matrix they produce. This structure protects bacteria from antibiotics and the immune system far more effectively than if they lived in a free-floating state, making biofilms one of the most common causes of hard-to-treat chronic infections—such as respiratory infections in people with cystic fibrosis and chronic obstructive pulmonary disease (COPD), chronic wounds, or infections associated with catheters and prosthetic devices. Added to this is the global rise in antibiotic resistance, which makes it increasingly urgent to have tools capable of predicting which treatment will work in each case.
The ocean's aphotic zone—the dark, high-pressure region below the surface, where sunlight cannot reach—is home to a vast wealth of microbial life. Yet scientists know relatively little about the genetic makeup, growth and function of many of these enigmatic organisms.
The ocean's aphotic zone—the dark, high-pressure region below the surface, where sunlight cannot reach—is home to a vast wealth of microbial life. Yet scientists know relatively little about the genetic makeup, growth and function of many of these enigmatic organisms.
Researchers at Queen Mary University of London are closer to understanding tendinopathy, a common condition that can cause persistent pain and impaired movement in people and many animals.
In recent years, there has been a lot of excitement about the potential for studying human diseases in what are called "organoids." These small patches of tissue, formed using stem cells, appear to produce many of the same cell types and at least some of the structures normally formed in actual organs, and thus can provide a better model for diseases that rely on the sometimes complex interactions among multiple specialized cell types that are a feature of the human body.
But even the most sophisticated organoids lack a lot of the features of a real human body. This is especially true for brain organoids, which don't form any of the connections with specialized brain structures needed to behave "normally." On Wednesday, a research group at Stanford University described a possible way to study brain organoids in a somewhat more natural context: They genetically wiped out a large portion of the mouse brain and replaced it with human brain organoid cells.
The replacements
Organoids, because they adopt a three-dimensional tissue structure and consist of various specialized cells, provide a much better model for an intact tissue than simply having a bunch of disassociated cells lying flat on a culture dish. But they still have a lot of limitations—they're not hooked up to a circulatory system that allows the liver to process chemicals the organoid produces and don't have immune cells moving through them, to give just a couple of examples.
In recent years, there has been a lot of excitement about the potential for studying human diseases in what are called "organoids." These small patches of tissue, formed using stem cells, appear to produce many of the same cell types and at least some of the structures normally formed in actual organs, and thus can provide a better model for diseases that rely on the sometimes complex interactions among multiple specialized cell types that are a feature of the human body.
But even the most sophisticated organoids lack a lot of the features of a real human body. This is especially true for brain organoids, which don't form any of the connections with specialized brain structures needed to behave "normally." On Wednesday, a research group at Stanford University described a possible way to study brain organoids in a somewhat more natural context: They genetically wiped out a large portion of the mouse brain and replaced it with human brain organoid cells.
The replacements
Organoids, because they adopt a three-dimensional tissue structure and consist of various specialized cells, provide a much better model for an intact tissue than simply having a bunch of disassociated cells lying flat on a culture dish. But they still have a lot of limitations—they're not hooked up to a circulatory system that allows the liver to process chemicals the organoid produces and don't have immune cells moving through them, to give just a couple of examples.
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