A square peg doesn't fit a round hole. But what if the peg could change the shape of the hole? A newly developed drug molecule can do something surprisingly similar when binding to its target protein, according to a University at Buffalo-led study published Tuesday (Sept. 15) in Angewandte Chemie International Edition.

A square peg doesn't fit a round hole. But what if the peg could change the shape of the hole? A newly developed drug molecule can do something surprisingly similar when binding to its target protein, according to a University at Buffalo-led study published Tuesday (Sept. 15) in Angewandte Chemie International Edition.

The development of cooking was a major milestone in the evolution of human civilization because it made food easier to digest and more energy-efficient. Heating food can also kill harmful pathogens and make certain foods taste better. Overcooking, on the other hand, can have adverse effects, particularly on proteins.

The biopolymer lignin—one of the most important carbon reservoirs in plants and soils—not only decays through fungi or bacteria but can also be chemically attacked by iron linked to reactive oxygen species, without the involvement of microorganisms. When this happens, lignin is converted into methanol and subsequently into formaldehyde. That is shown by a study conducted at Heidelberg University's Institute of Earth Sciences.