The Corps of Discovery Expedition set out in 1804, directed by President Thomas Jefferson to survey the United States’ newly acquired Louisiana Purchase. The exploration forms a core piece of early U.S. history. Picture a scene from the journey: It’s a cool morning, the silence punctuated by birdsong and the rustle of the breeze through the cottonwood trees. To one side, Commander William Clark, his rifle leaning against a plum tree and his rucksack nearby, squats over a latrine pit, unceremoniously heeding the call of nature. 

The Louisiana Purchase constituted a territory of around 828,000 square miles, which the U.S. had bought from France in 1803. This was, it is worth noting, largely without the consent of the Indigenous groups who had lived there for millennia. The purpose of the expedition was threefold: to find a practical trade route westward to the Pacific coast, to explore and document the territory, and to stake a claim to the area before any other European powers butted in. Led by Meriwether Lewis and William Clark, the 40-man team, plus their guide Sacagawea, spent more than two years trekking westward.

Believe it or not, the holes that were used as toilets along the march to the Pacific have been invaluable for archaeologists and historians. This is thanks especially to a type of treatment included in the expedition’s medical kit. 

How Lewis and Clark went to the bathroom

Everybody poops—it’s a universal human need. But most accounts of the Corps of Discovery’s journey leave out the details of how the Corps members dealt with bathroom business. 

Each of the campsites where the expedition spent time had an accompanying latrine pit, situated well away from camp for sanitary (and privacy) reasons. The latrines would have seen a lot of use, because the Corps of Discovery’s diet wasn’t the best for gut health. 

While the expedition members relied heavily on foraged and hunted food, they also carried backup rations. These included nearly 14,000 pounds of dry goods, including flour, salt, coffee, dried pork, and lard. All told, each member of the Corps ate around nine pounds of meat per day. All of that protein without lots and lots of fiber added up to frequent constipation. The untreated water they drank from rivers and creeks they encountered probably didn’t help their circumstances. Enter…Dr. Rush’s Bilious Pills. 

The mercury constipation pills known as “thunderclappers”

In 1803, as preparation for the upcoming expedition, William Clark traveled to Philadelphia for a two-week medical crash course with Dr. Benjamin Rush. Rush was a prominent physician in his day, and a Founding Father of the United States. His signature is one of the 56 on the Declaration of Independence.

Rush taught Clark some basic field skills, such as bone-setting and wound treatment. Clark left Philadelphia with new skills and a well-stocked medical kit that included 50 dozen of Doctor Rush’s Bilious Pills. These were compounded tablets about the size of a raisin, composed of powerful laxative ingredients. The pills were nicknamed “thunderclappers” because of the speed with which they took effect. The main ingredient of the thunderclappers was calomel, or mercury chloride. 

Mercury, historically also called quicksilver, has been thought to have curative effects for centuries. It’s a metal that is liquid at room temperature, which seems miraculous in and of itself. 

It was also a popular treatment for syphilis. This is not to say it was an effective treatment for syphilis. When it was administered for that disease, slowly in low doses, patients were more likely to die from mercury poisoning than from the STI. 

When taken in larger doses, though, as in the thunderclapper pills, it prompted a quick evacuation, the body’s way of ejecting poison. The men of the Lewis and Clark expedition used these pills freely as a way to compensate for their high-protein and low-fiber diet. As a result, all the latrine pits they used between the Midwest and the Pacific coast were laced with high concentrations of mercury. 

Lewis and Clark pooped mercury. Today archaeologists use it to map their route.

As many an environmentalist will caution, mercury does not decompose when it’s in the ground. It stays put, and is detectable through modern soil testing techniques. The 600-plus latrines dug and used by the Corps of Discovery form a trail of their own, marked by mercury. 

The expedition was a government-sanctioned military expedition, so Lewis and Clark both kept copious notes on every aspect of their travels. Historians have tried to pinpoint the locations of these camps based on the expedition journals, with minimal success. 

The only campsite that archaeologists have been able to confirm so far is the Traveler’s Rest camp, just outside of Missoula, Montana. This is all thanks to the remains of Dr. Rush’s Bilious Pills, which left enough mercury in the ground to differentiate the remains of a latrine pit (or “sink” as they were called in the 1800s) from animal burrows or agricultural ditches. 

Archaeology is all about reconstructing the lives of people in the past, and it’s worth remembering that this means all aspects of life. Our own bodily functions remind us that we all share complex and interwoven histories, and that even the most mundane parts of our lives can be important in the future. 

In That Time When, Popular Science tells the weirdest, surprising, and little-known stories that shaped science, engineering, and innovation.

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Conventional gym etiquette involves carefully wiping down the surfaces of any machines or equipment after using it. Businesses usually provide customers with wet wipes, or simple sprays and towels, to keep faux leather padding and other public surfaces pristine and sanitary.

But during professional events, that level of cleanliness isn’t always guaranteed. Organizers of a recent Hyrox competition in China, the spiritual successor of the Crossfit craze, have been accused of allowing participants be exposed to a trail of human waste — left behind, memorably, by the athlete who went on to win the competition.

As The Guardian reports, Australian world record holder Joanna Wietrzyk used shared stations, including rowing machines, sleds, and medicine balls, while “faecal matter” was “visibly running down her legs,” a horrifying incident vaguely reminiscent of one of the most infamous and reviled videos in internet history.

The incident drew an outburst of disgust across social media.

“I guess I’m never doing a Hyrox event,” one user wrote in a post on Bluesky. “Oh my god.”

“Saw a big Hyrox poster at the gym and all I thought of was that lady shitting herself,” another tweeted. “That’s their brand now.”

“This should result in a hard stop for the competitor because the public health risk is more important than the medal,” one user argued. “Hyrox has way too many shared touch points and surfaces to let this continue.”

Others used the opportunity to poke fun.

“A s****y situation for all parties and tough for Hyrox to save faeces,” another joked.

Organizers were criticized for allowing the competition to continue despite having clear bio-contaminant rules in place.

“Protocols designed for elite competition and mass participation became blurred, creating ambiguity in how they were applied and understood,” Hyrox World wrote in an statement, in one of the more acrobatic euphemisms we can recall.

Hyrox cofounder Moritz Fürste issued an apology on Instagram as well.

“Hyrox made a mistake by not reacting immediately during the race,” he wrote. “In the end it is my job to foresee these potential incidents — and I did not.”

“Of course, we started improving event processes,” Fürste went on, “plus making rulebook changes immediately.”

The shocking incident highlights the fact that professional endurance athletes soiling themselves isn’t as rare as it may seem. Long distance runners, for instance, are known to suffer from “runner’s diarrhea,” like Paula Radcliffe, who had to relieve herself in full view of the public during the 2005 London marathon.

Radcliffe still won with a time of 2:17:42 — albeit with a little less dignity than she started.

More on athletes: They Held a New Olympics Where Athletes Can Take as Many Drugs and Steroids as They Want, and the Funniest Possible Thing Happened

The post Spectators Horrified as Hyrox Athlete Recreates “Two Girls One Cup” at Live Competition appeared first on Futurism.

Despite major strides in education and conservation efforts, rabies remains a serious public health issue. The Center for Disease Control (CDC) estimates around 90 percent of cases occur in wildlife, but their consequences still reverberate across ecosystems and routinely endanger humans. Combating the viral disease costs the United States over $300 million every year, but the hefty price tag is justified. Contracting one of the oldest known diseases invariably causes severe symptoms like abnormal sensations, violent movements, hydrophobia, and loss of consciousness. Rabies is fatal in virtually every documented case, and still kills around 59,000 people around the world each year.

Once primarily associated with dogs, rabies has since spread to wildlife such as raccoons, skunks, bats, and foxes—making the issue much more difficult to track and control. Since 1995, the United States Department of Agriculture (USDA) has overseen a National Rabies Management Program in cooperation with state and federal departments, university researchers, and other organizations. After over 30 years of work, one of the most preferred mitigation methods is regularly placing oral rabies vaccine (ORV) bait in strategically selected wildlife areas. The easiest way to spread millions of bait blocks across thousands of square miles? Airdrops.

Next month, the USDA will once again begin tossing fishmeal-coated ORV packets from planes throughout the Southeastern states of Virginia, North Carolina, Tennessee, Georgia, and Alabama. These tiny edibles are specifically crafted to target the most prominent rabies variants seen in raccoons, coyotes, and gray foxes.

“The goal is to prevent westward spread of raccoon rabies by creating a continuous vaccine barrier that stays in front of rabies occurrence on the landscape,” a USDA spokesperson recently told FOX Carolina News. The representative added that although the distribution’s scope doesn’t currently include South Carolina, they are “very close to establishing an ORV area in South Carolina counties bordering North Carolina and Georgia in the next few years.”

If all goes as planned, the National Rabies Management Program’s geographic scope will shrink over time as the disease is regionally eliminated. Until then, anyone who accidentally comes into contact with an ORV bait brick shouldn’t worry about contracting the disease. The vaccine inside each brick is proven safe for over 60 animal species, including cats and dogs. If you happen to locate one in a residential area, the USDA recommends to either simply leave it alone, or use gloves to move it to a more remote location for its intended recipients. Always wash your hands thoroughly after handling ORV bait—and try to ignore the pungent odor of fishmeal.

The post It’s almost time to airdrop rabies vaccines again appeared first on Popular Science.

This novelist has spent a good part of his medical career training others for emergencies, and acting in emergencies himself. He takes them seriously. 

Source

Scientists are exploring new ways to regain control of overactive nervous systems including humming, tapping on the skin and cold-water immersion.

Here’s a hazard you probably didn’t expect from too much screen time.

Two doctors in the UK reported in the journal BMJ Case Reports the bizarre case of a young boy whose laptop literally toasted his skin over weeks and maybe even months of using it. Thankfully, the kid’s fine and was never in any real pain, so we can dive into this medical oddity without feeling too guilty about it.

According to the eyebrow-raising paper, spotted by Ars Technica, the boy was first brought into an emergency department with reddish markings over his abdomen in a lace-like pattern. Nurses first described it as “spontaneous bruising,” but they didn’t find skin abnormalities anywhere else on his body. The boy also wasn’t in any pain, and didn’t have any history of trauma or illnesses that could explain the markings.

When doctors did a chest x-ray, they found some kind of build up in his lung, though it was unclear what it signified. The boy admitted that he got pushed into a chair while play-fighting with his siblings a week ago, leading the doctors to search for signs of a traumatic injury. But after a CT scan, they didn’t find any. They weren’t completely sure of what was going on, but the doctors discharged him with antibiotics for a suspected lung infection.

The boy was back several weeks later, though — and the rash was even worse. Parts of his abdomen were pinkish, exhibiting clear signs of skin breakdown, the doctors wrote, with mottled patches of dark brown. (You can view a photo, at your own peril, here, via Ars.)

That’s when the doctors began to suspect some kind of heat damage. But when they asked the boy about heat sources, nothing turned up. 

Then, as they continued to question him, the boy mentioned something crucial: he was home-schooled and did most of his assignments on his laptop, sometimes for eight hours a day, often while charging. And of course, he usually rested the laptop on his torso while lying down.

This supported a diagnosis of a erythema ab igne (EAI), also known as “toasted skin syndrome.” It’s caused by repeated, close exposure to low heat, which slowly damages the skin over time. Patients often get it from heat pads and space heaters, but a warm laptop can cause it, too. It causes a distinctly lace-like rash, which explained the boy’s symptoms.

EAI is benign, and in most cases, its rashes disappear on their own once exposure to a heat source is stopped, taking weeks to months to heal. Once properly diagnosed, the boy’s rash was dressed, and he came back to the hospital several months later to confirm that he had fully healed. Now that he’s okay, he might try studying at a desk instead.

More on medical oddities: Man Announces That He Has Synthesized a New Schizophrenia Treatment in His Garage, Based on a Formula Devised by ChatGPT

The post Laptop Toasts Boy appeared first on Futurism.

The myriad horrors of the US healthcare system have spawned generations of medical tourism from the wealthiest country on Earth to the periphery: Cuba, Mexico, Costa Rica, Canada, Turkey, and Thailand, to name just a few.

Now, Shanghai is quickly rising as one of the top destinations for cancer patients, as China’s biotech sector has spun an experimental treatment developed in the US into a standalone industry.

New reporting by the Wall Street Journal took a look at this fast-growth industry, centered around chimeric antigen receptor T-cell therapy, or CAR-T for short.

CAR-T is essentially a personalized form of immunotherapy, in which a patient’s own white blood cells are engineered to identify and attack specific proteins found in cancer cells. Though the process was first developed by US biotech giants, their inability — or unwillingness — to lower the cost and increase supply of the treatment has led to shortages throughout the country.

That’s where China comes in. As director of the CAR-T program at the University of Texas MD Anderson Cancer Center in Houston Sairah Ahmed told the WSJ, this therapy can cost around $150,000 to $230,000 in China — still a life-altering bill, but a sizeable discount compared to an insurmountable $550,000 to $850,000 in the US.

This, Ahmed says, is why she advises some patients to seek out treatment in the People’s Republic.

“China has basically done to CAR-T cell therapy the same thing that it’s done to other industries, which is, they’ve industrialized it,” Ahmed explained.

China’s CAR-T services aren’t just cheaper, either. They’re also faster, and come with a host of complimentary after-care treatments, the WSJ notes. As MD Anderson Cancer Center’s explainer on CAR-T therapy advises, the process of extracting and bio-engineering a patient’s cells to fight cancer can take over three weeks in the US. Compare that to China, where the WSJ reports labs near Shanghai can “crank out” the therapy in just a matter of days.

An important caveat here is that CAR-T cell therapy isn’t a catch-all for every type of cancer, and it’s typically only administered after other treatments have failed. It’s not exactly a walk in the park, either, requiring months of recovery and check-ups from a range of physical, neurological, and psychological health specialists. Still, if you had to go through with it, your first step should clearly be pricing out some flights to China.

More on healthcare: Bougie Health Startups Offering Full-Body Diagnostic Scans for Rich People While the Rest of Us Suffer a Crumbling Healthcare System

The post America’s Health Care System Is So Screwed That Patients Are Flying to China for Cancer Treatment appeared first on Futurism.

As far as completely pointless ways to kill time on your phone, this is certainly one of the weirdest on record.

Behold the all-new invention of so-called “dopamine sites” — digital domains where you can browse and hunt for deals on nonexistent wares and services. Clothes, food delivery, you name it: you can pretend-shop for it all. 

You don’t actually buy anything, crucially. You’re just pretending to have money to buy the things you want. It’s window-shopping reimagined for the age of doomscrolling.

But it’s also a little more than that. These cleverly-built sites simulate the experience down to checking out and “tracking” your shipment or delivery, and their absurdly realistic rituals can help people become more conscious of their spending habits. Supposedly. 

The trend, according to the New York Times, originated in South Korea this spring, when Park Seohyun, a 21-year-old mechanical engineering student in Seoul, created a fake food-delivery site called “Food Never Arrives.” (It’s now an app).

Originally intended as a joke, she says, it lets you not only order nonexistent food, but provides you an estimate of the money and calories you saved by skipping on the real thing. 

In a wintry economic climate, it became an unexpected hit.

“People began sharing it online and discussing whether it actually helped them resist ordering food,” Park told the NYT.

A wave of imitators followed. This summer marked the launch of “FakeHaul,” a dopamine site built by a Microsoft engineer that convincingly imitates shopping on Temu. Two developers in India inspired by Park’s site, Purvansh Parmar and Anshul Sharma, created “Food Never Comes,” which simulates food deliveries but provides real recipes for the food you didn’t actually order. Parmar and Sharma told the newspaper that their site had more than 2.7 million views since launching in June.

Whether these dopamine sites provide anything more than fleeting, empty pleasures is something experts are more skeptical about. Ravi Dhar, director of the Yale Center for Customer Insights, told the NYT that the “element of looking forward brings a lot of the pleasure, and we often crash after an event or feel let down.” Lingguo Xu, a behavioral economist studying anticipatory utility, warned that the dopamine tricks could quickly get old. And by simulating consumption, you risk developing “stronger cravings.”

Some take the original idea beyond getting high on simulated shopping. Ko Seojin, another South Korean developer, created a website for taking virtual smoke breaks called Damta World. You click to start smoking an animated cigarette, which starts burning on screen. You can “whisper” disappearing messages to other smokers on break, while a counter keeps track of the number of cigarette butts that have been tossed on the office rooftop each day.

Ko told the NYT that 150,000 people visit each month, and she says that some users have become real-life friends after meeting on the website. Those friendships, we hope, are something that’ll last longer than any fake-shopping dopamine hit.

More on your brain on tech: Psychologist Says AI Is Causing Never-Before-Seen Types of Mental Disorder

The post Bizarre New Websites Are Designed Specifically to Spark Dopamine in Your Brain appeared first on Futurism.

GLP-1 weight loss drugs are changing lives in more ways than one.

In a new piece for The Guardian, the newspaper’s readers share how the weight loss journey that drugs like Wegovy, Ozempic, and Mounjaro have set them down on have drastically affected their interpersonal relationships — sometimes for the better, and sometimes for the worse. 

Many of the GLP-1 users seem to harbor a sense of shame, hiding their use of the drugs. In their minds — and perhaps in the minds of those around them — they undermine the sense of accomplishment that comes with losing weight the old fashioned way, instead feeling that they “cheated” or are “being dishonest” about how they achieved their goals. 

One parent wrote of how their 20-year-old daughter felt “worried, angry, and jealous” after she discovered they were hiding their use of Wegovy from her. “We had discussed weight, identity and GLP-1s, but I was so ashamed of going on it that I didn’t want to tell anyone,” they wrote, noting how food was a “huge part of our family life.” They wondered to themselves: “What kind of signal am I giving her and her brothers?” 

Though they feel “mostly positive” about losing nearly thirty pounds using the drug, they added, they also can’t shake the feeling that they’re “cheating.”

“So much of my insecurity about my weight and appearance is offloaded on to an injectable pen,” they added.

Another wrote that despite their friends feeling pleased about their weight loss, they’ve kept their GLP-1 drugs secret for nearly two years. Their partner, they believe, “has felt insecure at times because of my glow-up.”

“I don’t want people to think I’ve cheated. I guess there is still fat shame somewhere,” they wrote.

Others don’t feel this guilt, but are frustrated that their spouses don’t realize how transformative the drugs have been for them. One complained that their husband was so unsupportive of their use of GLP-1s that they no longer could share their experience with him.

“This has been a life-changing drug so far, and I can’t share it with the person I’m closest with,” they lamented. 

Though they’ve struggled with obesity their whole life, their “husband scoffs at characterizing obesity as a chronic and recurring disease” and “thinks people should just make better lifestyle choices and stop making excuses — which tells me a lot about how he views me, too.”

These downsides aren’t unique to GLP-1s. Significant weight loss has long been linked to divorce, and that doesn’t necessarily mean that someone who’s slimmed down is now feeling their oats. Weight loss can come with dramatic changes to a person’s lifestyle — from the food they eat and the exercise they do to how they socialize — and that can be a lot for someone close to them to adjust to.

“Relationships tend to develop a sense of equilibrium and predictability over time,” Lindsey Berisha, a clinical psychologist who’s worked with patients using GLP-1s for over a decade, told The Guardian. “When one partner undergoes a significant change, it can shift that equilibrium, and even positive change can create uncertainty for both partners.”

GLP-1s, of course, have made achieving this kind of significant weight loss much more accessible, which is why we’re now starting to hear about “Ozempic divorces.”

More on GLP-1s: GLP-1 Drugs Appear to Prevent Cancer, New Research Finds

The post GLP-1 Users Are Being Cruelly Shamed by Their Own Families appeared first on Futurism.

The anniversaries come and go, but the physical and mental health of workers and survivors is still being affected by September 11, 2001.