A protein known for circulating in the blood to fight infection plays a very different role when produced by cells inside tumors. A protein that emerged long before animals developed circulatory systems may influence whether cancer immunotherapy succeeds. Researchers at Nagoya University in Japan found that complement C3 helps keep immunosuppressive cells out of tumors, [...]

A protein and signaling pathway may help overcome the developmental block that keeps some leukemia cells immature. Inside the bone marrow, immature blood cells normally pass through a tightly controlled sequence of development before taking on specialized roles. In aggressive forms of leukemia, some of these precursor cells become trapped partway through that process. Instead [...]