Experimental Copper-Based Drug Clears Alzheimer’s Plaques and Boosts Memory in Mice

15 June 2026 at 19:53

Using the APP/PS1 mouse model of familial Alzheimer’s disease, Pyun et al. investigated the effect of Cu(ATSM) on brain microvascular abundance and function of P-glycoprotein and the associated effects on exogenous amyloid-beta clearance, brain amyloid burden, and cognitive function. Image credit: Pyun et al., doi: 10.1021/acschemneuro.6c00252.

Copper diacetyl bis(4-methyl-3-thiosemicarbazone), or Cu(ATSM), restored a key waste-removal system in the brain, reducing toxic amyloid-beta buildup and improving spatial memory in lab models of Alzheimer’s disease, according to a team of researchers at Monash University.

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