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Hybrid graphene–MXene–WS₂ terahertz metasurface detects chikungunya virus via machine learning

11 September 2026 at 11:38

Scientists have unveiled a computational design for a terahertz metasurface biosensor that combines five distinct materials—graphene, MXene, tungsten disulfide, gold, and copper—into a single multilayer architecture capable of detecting refractive-index changes associated with chikungunya virus infection. The study, published in Results in Optics by G. Arunachalam, A.R. Kalaiarasi, Giri.G. Hallur, and V. Parthasarathy, reports a numerically predicted sensitivity of 907 GHz per refractive-index unit, among the highest values reported for hybrid-material terahertz biosensors, and couples the electromagnetic design to an XGBoost machine-learning surrogate model that predicts sensor behavior with accuracies exceeding 99.8 percent.

Chikungunya virus is an enveloped, positive-sense single-stranded RNA alphavirus transmitted primarily by Aedes aegypti and Aedes albopictus mosquitoes. While mortality remains low, generally below 0.1 percent, the broader public health burden arises from severe polyarthralgia that can persist for months or even years in a substantial fraction of patients across tropical and subtropical regions. With no approved antiviral therapy or licensed vaccine currently available, diagnostic accuracy sits at the center of clinical management and transmission control. Yet existing diagnostic tools face significant practical constraints, particularly in point-of-care and field settings.

Serological methods such as enzyme-linked immunosorbent assay suffer from cross-reactivity with related alphaviruses, including Ross River and O’nyong-nyong viruses, reducing diagnostic specificity. Real-time reverse transcription polymerase chain reaction offers high sensitivity during the acute phase but depends on laboratory infrastructure, trained personnel, and controlled sample handling. Virus isolation in cell culture provides confirmatory results but requires biosafety level-3 facilities and extended processing time. These limitations have motivated the search for rapid, label-free sensing approaches capable of operating at clinically relevant concentrations in decentralized environments.

The new work turns to the terahertz band, spanning roughly 0.1 to 10 THz, which lies between microwave and infrared regions of the electromagnetic spectrum. Terahertz radiation is non-ionising, with photon energies in the millielectronvolt range, allowing interaction with biological samples without causing ionising damage. Crucially, terahertz waves couple to low-frequency vibrational and rotational modes of biomolecules such as proteins, nucleic acids, and polysaccharides, producing measurable spectral features that support label-free detection. Because biological media including blood plasma and viral suspensions exhibit refractive-index variations in this domain, differences on the order of 0.01 to 0.02 refractive-index units can shift resonance frequency and field distribution when coupled to resonant sensing structures.

The proposed sensor is built around a periodically repeated square unit cell containing two identical square resonators, 2000 nanometers on a side, coated with tungsten disulfide—a two-dimensional transition metal dichalcogenide with strong light–matter interaction, high carrier mobility, and excellent dielectric confinement. This layer localizes the electric field in the sensing region and increases the interaction volume between the resonant field and the surrounding analyte. A pair of concentric circular rings, 3200 and 3800 nanometers in diameter and functionalized with MXene, surrounds the resonators, enhancing electromagnetic coupling, promoting efficient charge transport, and strengthening plasmonic interactions between resonator elements. An outer gold ring, 6000 nanometers in diameter, serves as the main plasmonic resonator supporting strong localized surface plasmon resonances with low optical loss. The entire multi-resonant assembly is embedded within a monolayer graphene sheet measuring 14,000 by 14,000 nanometers, which acts as a broadband absorber and a high-mobility charge transport medium whose electrically tunable chemical potential allows dynamic, active control of the resonance characteristics. Copper elements woven into the architecture provide supplementary conductive pathways that reinforce current distribution and coupling among the hybrid resonators. The structure rests on a silicon dioxide substrate, chosen for its low dielectric loss and mechanical robustness, which preserves the resonance quality factor.

The authors stress that the multilayer design is compatible with established microfabrication techniques. Fabrication would begin with a cleaned silicon dioxide substrate, followed by polymer-assisted transfer of monolayer graphene and thermal annealing. Gold and copper resonators can be deposited through electron-beam evaporation or magnetron sputtering with lift-off patterning, MXene rings through solution-based deposition, and the tungsten disulfide layer through chemical vapor deposition or thin-film transfer. With a unit-cell dimension of approximately 14 micrometers, the required feature sizes fall comfortably within conventional photolithography capabilities, and because fabrication imperfections remain far smaller than the operating terahertz wavelength, moderate tolerances are expected to have only limited influence on the electromagnetic response. For biosensing, the graphene surface could subsequently be functionalized with chikungunya-specific antibodies or aptamers using EDC/NHS or pyrene-based linker chemistries.

The electromagnetic modeling, performed in COMSOL Multiphysics, reveals a pronounced resonance at 0.355 THz, where electric-field simulations show the strongest and most spatially extensive enhancement. Varying the graphene chemical potential from 0.1 to 0.9 electronvolts produced dramatic modulation of the transmission contrast, which increased roughly 36-fold at the highest bias, from less than one percentage point to more than 27 percentage points, while peak transmission remained essentially unchanged above 98.6 percent. This asymmetric response—stable maxima paired with strongly modulated minima—arises because increasing chemical potential enhances graphene’s intraband conductivity, deepening resonant absorption through stronger light–matter interaction. The sensor also demonstrated remarkable angular robustness, maintaining peak transmittance above 97.8 percent across incident angles from 0 to 80 degrees, an important tolerance for realistic deployment where normal incidence cannot always be guaranteed.

Geometric optimization identified an outer circular resonator radius of 2500 nanometers and a square resonator side length of 2500 nanometers as the dimensions that maximize resonance strength, driving minimum transmittance down to approximately 65 to 67 percent and signifying optimal electromagnetic confinement within the active sensing region. When evaluated across refractive indices from 1.33 to 1.39, a range encompassing reported values for healthy plasma (approximately 1.35 RIU), healthy platelets (1.39 RIU), chikungunya-infected plasma (1.33 RIU), and infected platelets (1.38 RIU), the optimized configuration achieved a maximum sensitivity of 907 GHz/RIU, a figure of merit of 18.519 RIU⁻¹, a minimum detection limit of 0.061 RIU, a sensor resolution of 55.178, and a refractive-index resolution of 0.001 RIU. In comparative benchmarks against recently reported graphene- and hybrid-material-based terahertz biosensors—including graphene/copper/aluminum, graphene/silicon dioxide, MXene–graphene–black phosphorus, and graphene-integrated copper–silver designs—the proposed architecture’s sensitivity exceeded most published values, reflecting the synergistic field confinement produced by the five-material stack.

The machine-learning component addresses one of the central bottlenecks in metasurface development: the computational cost of repeated full-wave finite-element simulations during structural optimization. The team trained an XGBoost regressor, an ensemble method based on gradient-boosted decision trees, on simulation data covering incidence-angle variation and circular-ring dimension variation, using stratified sampling with 80 percent of data for training and 20 percent held out for independent testing, alongside five-fold cross-validation and grid-search hyperparameter optimization. The model captured more than 99.7 percent of response variance on unseen data, with mean absolute percentage errors below 0.162 percent and prediction accuracies from 99.838 to 99.959 percent. Acting as a computational surrogate, the trained model enables rapid interpolation across the design space without sacrificing the fidelity of the underlying electromagnetic model.

The authors are careful to frame the work as a computational proof-of-concept rather than an experimentally validated diagnostic. The sensor detects changes in the local dielectric environment surrounding the resonators, not viral particles or nucleic acids directly, and refractive-index sensing alone cannot intrinsically distinguish chikungunya from other viruses with similar dielectric properties. Analytical specificity in practice will depend on surface biofunctionalization with chikungunya-specific recognition molecules immobilized on the graphene or gold sensing surface. Future work will focus on device fabrication, biofunctionalization, calibration with reference refractive-index standards, experimental validation with clinically relevant plasma and platelet samples, and systematic evaluation of selectivity against related arboviruses—steps that would transform this numerically validated platform into a practical tool for rapid, label-free infectious disease diagnostics in the field.

Subject of Research: Label-free terahertz metasurface biosensing for chikungunya virus detection using a hybrid graphene–MXene–WS₂–Au–Cu architecture with machine-learning-assisted optimization

Article Title: Hybrid graphene–MXene–WS₂ terahertz metasurface detects chikungunya virus via machine learning

Article References: Arunachalam, G., Kalaiarasi, A., Hallur, G., & Parthasarathy, V. (2026). Machine learning-assisted hybrid graphene–MXene–WS₂ terahertz metasurface biosensor for highly sensitive label-free chikungunya virus detection. Results in Optics, 25, Article 101149. https://doi.org/10.1016/j.rio.2026.101149

Image Credits: AI Generated

DOI: 10.1016/j.rio.2026.101149

Keywords: chikungunya virus detection, computational biosensor design, high sensitivity biosensors, hybrid graphene MXene WS₂, machine learning in biosensing, multilayer architecture, nanomaterial-based sensors, public health diagnostics, refractive index sensing, terahertz metasurface biosensor, virus diagnosis in field settings, XGBoost surrogate model

Unveiling how nanoparticles create iridescence in ancient ceramics

10 September 2026 at 21:50
Scientists led by the Universitat Politècnica de Barcelona and the ESRF, the European Synchrotron, have revealed the chemical reactions in nanoparticles that created a unique, shimmering effect in the painting on ninth-century Islamic ceramics. The results are published in Science Advances.

Semiconducting nanorods help laser-powered drones keep cool

18 August 2026 at 16:43

Remote uncrewed aerial vehicles (UAVs), or drones, equipped with solar cells could be wirelessly charged using laser beams directed at them from the ground, rather than relying on traditional onboard batteries. The problem until now, however, has been keeping the drones cool – since laser light heats them up, so reducing the efficiency of the photovoltaic cells they carry on their wings. A team of researchers at the Civil Aviation University of China has now overcome this problem by incorporating a heat blocking technology based on antimony selenide (Sb2Se3) nanorods into these solar cells.

As drones take on longer missions, battery life has become one of the biggest barriers, explains Jianhua Han, who led this new research study. “Our team has been looking into laser wireless power transmission, which is a leading approach for long-distance wireless energy transfer, to replace these batteries.”

Laser wireless power transmission is particularly suited to aerospace applications such as UAVs equipped with photovoltaic cells. Perovskite solar cells show much promise in this context because they are cheap to manufacture, absorb light strongly in the visible part of the electromagnetic spectrum and have long charge-carrier diffusion lengths.

A perovskite laser cell-thermoelectric tandem device

In the new work, detailed in Matter & Light, Han and colleagues studied a type of solar cell known as a perovskite laser cell-thermoelectric (PLC-TE) tandem device, which consists of a carbon-based CsPbBr3 perovskite as the PLC and bismuth telluride (Bi2Te3) as the TE material. The TE module is directly fixed beneath the laser cell and a carbon electrode is attached to its negative terminal  to create a series connection. When laser light is shone onto the device, the carbon electrode converts a portion of the incident laser energy into heat. The TE then harvests this heat, converting it into electricity through the thermoelectric effect.

And that’s not all: since one side of the device ends up being warmer than the other, this temperature gradient also helps convert the thermal energy into electricity. The larger the temperature gradient, the more electricity the TE layer can generate.

There is a problem though: while the carbon in the hybrid structure dissipates some of the heat produced by the laser, the structure can still heat up – reaching temperatures of up to 90°C, says Han. “That was much higher than we expected and made us realize that heat buildup was a far more serious problem than we had imagined.”

Sb2Se3 behaves like a thermal barrier

To overcome this problem, the researchers turned to Sb2Se3, which is a promising photovoltaic material. As well as its good optoelectronic properties, this semiconductor also has a low thermal conductivity, which allows it to behave like a thermal barrier when embedded in a device.

Han’s team synthesized nanorods from the Sb2Se3 and incorporated them into the upper portion of the CsPbBr3 layer. The Sb2Se3 reduces heat dissipation in the carbon electrode and so helps maintain a significant temperature gradient in the TE device, thereby improving its overall energy conversion efficiency. Its thermal barrier properties also help decrease the PLC’s overall operating temperature during prolonged laser exposure.

The team then inserted the tandem device containing the Sb2Se3 nanorods beneath the wing of a stationary drone and carved out air channels through the wing to simulate real-world airflow conditions. When illuminated with high-power green laser light with a wavelength of 520 nm, they found that the device converted 38.49% of the incoming laser energy into electricity and successfully powered the drone’s propellor blade. This power conversion efficiency, says Han, is among the highest reported for this class of technology operating under similar conditions.

Device could help UAVs stay airborne for longer

“In terms of concept, this is the first time that a system-level scheme of the devices has been applied to a UAV power supply, expanding the work from pure materials research to application-oriented system design,” Han tells Physics World. “It demonstrates that powering UAVs with light is not just a theoretical concept, but an engineering pathway that can be practically implemented.”

The device could help UAVs stay airborne for longer, something that will be useful for applications like forest patrol, disaster monitoring and delivering packages, he says. But there is still much work to do before such applications become a reality. For one, the researchers will need to integrate the PLC-TE device into a lightweight drone for flight testing outdoors and to assess the safety of their technology. They will also need to find a way of accurately tracking moving drones with laser beams.

“Going from the ground-based proof stage to the real flight validation stage will require solving many engineering challenges,” says Han, “but our technology is a good starting point and verifying its viability is the core objective for the next phase in our study”.

The post Semiconducting nanorods help laser-powered drones keep cool appeared first on Physics World.

Metasurface Breakthrough Makes Blistering Laser Light Speeds a Reality

4 August 2026 at 13:24

The speed of laser light is due for a major upgrade after an international collaboration of scientists has developed a breakthrough nanomaterial. The new metasurface can steer and shape light beams at unprecedented speeds of just 74 quadrillionths of a second.

Scientists at UC Berkeley and Tel Aviv University revealed their new optical surface, developed in a Caltech lab, in a recent paper published in Nature Nanotechnology.

According to the team behind the breakthrough, their work will have ramifications for communications, sensing, imaging, and even quantum technologies, providing a new benchmark for “high-speed” light manipulation.

Light Control

Since the fiber-optic advancements of the 1980s, lasers and light pulses have underpinned some of our most crucial cutting-edge technologies. Advanced computers, communications systems, sensors, and even the elusive quantum systems all rely on controlling light.

While the speed of light is so incredibly fast that physicists consider it a constraint on the maximum speed that matter can travel through the vacuum of space, the speed at which our technology reacts to it is far slower.

The scientists’ breakthrough metasurface contains silicon structures even smaller than the wavelength of light, resulting in an ultra-thin surface. Silicon’s optical properties change upon bombardment with laser pulses, a property that the team strongly enhanced with their nanostructure design. In their design, the properties of the material are modified via light pulses, which alter how the material influences a second beam of light impacting its surface. Notably, their metasurface allows for control of a beam of light without any moving parts, such as mirrors or lenses.

Real World Results

The team conducted laboratory tests in which they manipulated light beams by up to 13 degrees and reshaped them into different patterns.

“The key idea was to create a metasurface whose optical response is not fixed once it is fabricated,” said lead author Dr. Claudio Hail. “By changing the illumination pattern, we can reconfigure how the device steers and shapes light, and do so on an ultrafast timescale.”

“For me, the most exciting aspect is seeing an idea that had been with us for years become an experimental reality,” said co-author Dr. Lior Michaeli. “The ultrafast effect we wanted to use is naturally very weak. We had to design the metasurface so that it would amplify the effect enough not only to measure it, but to use it to steer and shape light.”

While the metasurface produced record-breaking speeds under laboratory observations, exactly how fast it can operate remains uncertain. The researchers note that the switching time and the duration of the laser pulse were extremely close, which indicates that quicker pulses could push the optical surface’s speed even higher.

The Future of Light Technologies

One of the major potential advances that could come from this new metasurface includes systems that carry information primarily with light, end-to-end. Current communications systems use light to transmit messages, but those messages are converted into electrical signals for processing. By increasing the speed at which light can be manipulated, this would reduce the necessity to convert light signals into electrical ones, removing unnecessary actions in computing.

“This work points to a broader opportunity: using engineered structures to strengthen interactions between light and matter and turn them into tools for control, sensing, and information processing,” Dr. Michaeli said. “This is closely connected to research directions we are now pursuing at Tel Aviv University.”

Despite its promise, the work is still in the fundamental phase. Although not yet ready for practical use, the metasurface offers promise in future ultra-fast computing applications, where it may soon help to cut out the middleman of electronic conversion.

The paper, “Ultrafast, Reconfigurable All-Optical Beam Steering and Spatial Light Modulation,” appeared in Nature Nanotechnology on June 22, 2026.

Ryan Whalen covers science and technology for The Debrief. He holds an MA in History and a Master of Library and Information Science with a certificate in Data Science. He can be contacted at ryan@thedebrief.org.

Smart sensor identifies present molecules by remembering the past

2 August 2026 at 14:00
Most sensors are designed to do only one thing: detect what passes through them. But what if a sensor could do more? To create a new generation of technology, researchers have looked to living systems for inspiration. If a sensor could detect molecules, could it also remember previous interactions and selectively respond to them?

Mouldable glass screen could make mammograms clearer and much more comfortable

29 June 2026 at 14:00

A new glass screen containing nanoclusters of copper iodide could create higher-resolution X-ray images using a much lower dose of radiation. The scintillating screen, which also works underwater, can be moulded into curved shapes, overcoming key limitations of the conventional rigid, flat-panel detectors used for many medical imaging applications. These include mammography, say the researchers at King Abdullah University of Science and Technology (KAUST), Saudi Arabia, and the University of Hamburg, Germany, who developed it.

X-ray scintillators capture X-rays passing through an object and convert them into flashes of visible light to form a digital image, explains physicist Mehmet Bayindir of KAUST and the University of Hamburg. The more efficient the scintillator is at this conversion, the clearer the final image and the lower dose of radiation required to generate it.

He and his colleagues’ detailed analyses of a scintillator containing nanoclusters of copper, iodine and an organic ligand revealed a fascinating phenomenon: its photoluminescence and radioluminescence pathways appear to have distinct physical origins. This implies that the scintillating light yield – that is, how much visible light a material emits when struck by high-energy X-rays – can be separated from its standard photoluminescence quantum yield (how efficiently the material converts absorbed ultraviolet or visible light into a different wavelength of light).

Until now, Bayindir explains, it was assumed that a material must have high photoluminescence efficiency to perform well when excited by X-rays. “Breaking this assumption directly challenges conventional wisdom and opens up a promising new design space for making high-performance scintillators – provided that materials highly responsive to radiation can be engineered of course.”

Enter amorphous quantum systems

In recent years, researchers have been looking into cubane-type [Cu4I4L4, L: organic ligand] nanocluster glasses (NCGs) for use in this context. These belong to a family of hybrid transparent luminescent amorphous materials that show much promise for X-ray scintillation applications.

In their latest work, detailed in ACS Energy Letters, Bayindir and colleagues studied several stable alkyl-phosphine ligand-based NCGs. In these amorphous zero-dimensional quantum systems, ionizing radiation is mostly absorbed by the heavy iodine and copper elements at the cluster cores. The researchers used these NCGs to make large-area, free-standing scintillating screens – both planar and conformal – with ultrasmooth surfaces, using a fabrication methodology that they developed in their lab.

The screens are robust and can image samples – both electronic and biological – with sub-3 µm spatial resolution. They also work underwater, something that is difficult for conventional screens. The researchers demonstrated this by capturing a very clear scan of a fish’s tail in water that was indistinguishable from an image taken in air.

Such a glass scintillator represents a significant milestone, says team leader Osman Bakr. “Indeed, the level of precision we obtained allows us to capture highly detailed, high-contrast X-ray images of complex internal microstructures, such as the delicate anatomy of a microscopic insect and an electronic memory card, to cite but two examples,” he says.

X-ray imaging systems that curve to fit a person’s body

“Combined with the fact that this new nanocluster glass becomes almost rubbery when heated to 42 °C, we can mould it into any three-dimensional shape at low temperatures,” study lead author Bashir Hasanov adds. “This could allow for X-ray imaging systems that curve to fit a person’s body and overcomes the limitations of conventional rigid, flat-panel detectors.”

One possible application is in mammography, he notes. Today, a major drawback of current mammography machines is that breast tissue must be firmly compressed between flat panels so that it can be imaged. This is very uncomfortable – and even painful – and deters many women from going for a scan.

“One in 20 women around the world will be diagnosed with breast cancer in their lifetime, with annual cases projected to reach 3.2 million and related deaths climbing to 1.1 million by 2050,” says Bayindir. “Many of these fatalities stem from late-stage diagnosis.

Nearly one-third of women miss their initial mammogram appointments, something that significantly increases their risk of succumbing to the disease. “While the reasons for this vary, the medical literature frequently cites the physical discomfort of tissue compression,” says Bakr. “What is more, because current guidelines recommend starting routine mammography screenings at age 40, cumulative lifetime exposure to X-ray radiation remains a clinical concern for many. Our long-term objective is to completely redefine this clinical experience.”

Indeed, the researchers say they would now like to bring this quantum glass out of the lab and into real-world applications. Bakr tells Physics World that his team’s immediate next step is to scale up the geometric dimensions of its mouldable screens while maintaining perfect thickness and clarity. “This would move us closer to full-scale clinical prototyping for 3D conformal medical imaging.”

“We are also designing a novel detector architecture capable of high-resolution imaging on curved surfaces using an array of specialized optical sensors,” he reveals.

The post Mouldable glass screen could make mammograms clearer and much more comfortable appeared first on Physics World.

Thinner wires, faster electrons: Quantum material challenges copper at chip scale

17 July 2026 at 16:40
Electrical interconnects may very well be the unsung heroes of modern microchips. These tiny wires—typically made of copper due to its high conductivity—string together the billions of transistors that drive our computers and electronic devices. But as the technology advances and additional transistors are piled on, the components must shrink to the nanoscale. And that's when copper begins to fail.

Chemists shrink gallium nitride, the material behind LED lighting, into nanocrystals

16 July 2026 at 15:20
Nanocrystals are so useful that they formed the basis of the 2023 Nobel Prize in Chemistry. But despite their usefulness, scientists have so far been able to make these microscopic crystals from only a limited palette of materials. A group of chemists at the University of Chicago and Argonne National Laboratory has announced a way to make nanocrystals from a useful class of materials known as metal nitrides—a previously impossible task.

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