A couple of decades after the discovery of systems that could selectively target DNA, we're starting to see the first therapies based on gene editing. One challenge these developments have faced is safety. While we can make them pretty specific to the gene we want edited, the human genome is very large, and even rare DNA sequences can appear a couple of times by chance.
As a result, all the original gene-editing systems had known rates of what are called off-target effects, in which they simply edit the wrong sequence. This may be a low-probability event, but edit enough cells—and therapies generally have to edit many—and errors become inevitable.
A lot of effort has gone into finding ways to minimize or eliminate off-target edits. In a recent issue of Nature, researchers described modifying the AI protein-folding software AlphaFold to help identify key areas of gene-editing proteins responsible for off-target effects. Those areas were then modified to reduce the problems.
A couple of decades after the discovery of systems that could selectively target DNA, we're starting to see the first therapies based on gene editing. One challenge these developments have faced is safety. While we can make them pretty specific to the gene we want edited, the human genome is very large, and even rare DNA sequences can appear a couple of times by chance.
As a result, all the original gene-editing systems had known rates of what are called off-target effects, in which they simply edit the wrong sequence. This may be a low-probability event, but edit enough cells—and therapies generally have to edit many—and errors become inevitable.
A lot of effort has gone into finding ways to minimize or eliminate off-target edits. In a recent issue of Nature, researchers described modifying the AI protein-folding software AlphaFold to help identify key areas of gene-editing proteins responsible for off-target effects. Those areas were then modified to reduce the problems.
Hier à Londres, Samsung a dévoilé trois smartphones pliables avec les Galaxy Z Fold 8, Fold8 Ultra et Flip 8. La vraie rupture vient du Fold8. Il délaisse le format allongé habituel pour une silhouette presque carrée, façon BlackBerry, un choix qui pourrait préfigurer l'iPhone pliable, prévu par...
The rumors haven't left much to the imagination, but Samsung has unfurled its 2026 foldable lineup today. There are three models for the first time in Samsung's eight-gen foldable family, including the top-of-the-line Z Fold 8 Ultra. That phone is the successor to last year's Galaxy Z Fold 7, but the Z Fold 8 is new—the company's first wide-body foldable designed for media over multitasking. And then there's a new, thinner flip phone, plus a pair of smartwatches.
You can preorder Samsung's new hardware today, but the component shortage has made these already spendy product lines more expensive this year. Even the Z Flip 8 is now well over a grand, and the Ultra costs almost twice as much.
Specs at a glance: Galaxy Z8 series
Galaxy Z Flip 8 ($1,200)
Galaxy Z Fold 8 ($1,900)
Galaxy Z Fold 8 Ultra ($2,100)
SoC
Snapdragon 8 Elite Gen 5 for Galaxy
Snapdragon 8 Elite Gen 5 for Galaxy
Snapdragon 8 Elite Gen 5 for Galaxy
Memory
12GB
12GB, 16GB
12GB, 16GB
Storage
256GB, 512GB
256GB, 512GB, 1TB
256GB, 512GB, 1TB
Display
Main: 6.9" Dynamic AMOLED 2X (1080 x 2520) 400ppi, 120Hz; Cover: 4.1" AMOLED (948 x 1048) 342 ppi, 60/120Hz
Main: 7.6" Dynamic AMOLED 2X (1848 x 2448) 403ppi, 120Hz; Cover: 5.5" Dynamic AMOLED 2X (1248 x 1972) 428ppi, 120Hz
4,300 mAh, up to 55% charge in ~30 min with 25W Adapter, 15W Wireless Charging
4,800 mAh, up to 67% charge in ~30 min with 45W Adapter, 20W Wireless Charging
5,000 mAh, up to 63% charge in ~30 min with 45W Adapter, 20W Wireless Charging
Connectivity
5G, LTE, Wi-Fi 7, Bluetooth v5.4, SIM+eSIM
5G, LTE, Wi-Fi 7, Bluetooth v6.0, SIM+eSIM
5G, LTE, Wi-Fi 7, Bluetooth v6.0, SIM+eSIM
Measurements
Unfolded: 166.9 × 75.4 × 6.1 mm
Folded: 85.7 × 75.4 × 13.1 mm, 180g
Unfolded: 123.9 × 161.4 × 4.5 mm
Folded: 123.9 × 81.9 × 9.7 mm, 201g
Unfolded: 158.4 × 143.2 × 4.1 mm
Folded: 158.4 × 72.8 × 8.9 mm, 215g
Colors
Pink, Graphite, Cream, Mint (online)
Lavender, Graphite, Cream, Pistachio (online)
Violet Shadow, Graphite, Cream, Green Shadow (online)
The Z Fold 8 Ultra has the same basic form factor as the last few Samsung tablet-style foldables. A 6.5-inch OLED on the outside is about the same ratio as a standard smartphone screen. Open it up, and you get an 8-inch display that's roughly twice as wide. That makes the main display close to square.
Essas menções tratam-se de mensagens relacionadas à saúde do componente e chamam a atenção justamente por estarem no plural, já que os smartphones da Maçã contam com apenas uma célula de bateria em suas entranhas.
Foram identificadas, ao todo, três mensagens, as quais muito provavelmente serão exibidas em momentos distintos da vida útil dessas baterias. A primeira (em tradução livre), por exemplo, deverá ser exibida quando as células ainda são relativamente novas:
As baterias deste iPhone estão apresentando o desempenho esperado.
Já a segunda provavelmente entrará em cena assim que o desgaste da bateria começar a afetar a performance do “iPhone Ultra”:
A saúde das baterias deste iPhone se degradou significativamente. Um Centro de Serviço Autorizado Apple pode substituir as baterias para restaurar o desempenho e a capacidade totais.
A terceira, por fim, alertará usuários sobre componentes fabricados por terceiros:
A saúde das baterias deste iPhone sofreu uma degradação significativa, e não foi possível verificar se uma delas é uma bateria original da Apple. Um Centro de Serviço Autorizado Apple pode substituir as baterias para restaurar o desempenho e a capacidade totais.
O iOS, é claro, já exibe mensagens parecidas no seção “Saúde da Bateria e Carregamento” do menu “Bateria”, presente no app Ajustes (Settings), de modo que a novidade aqui é mesmo a linguagem adaptada para um dispositivo com mais de uma bateria. Como o “iPhone Ultra” provavelmente será dividido em duas partes, é bem possível estejamos falando de um par de células.
There is a lot of heat inside a modern smartphone. Apple knows this, and it is reportedly taking steps to cool things down for its future devices. Recent reports from the supply chain show the company is ordering a lot more vapor chambers. These cooling parts are essential for keeping high-end devices from overheating, and […]
Profitez des soldes d'été pour vous offrir le Samsung Galaxy Z Fold6 à un tarif exceptionnel. Ce smartphone pliable haut de gamme, capable de se transformer en tablette de 7,6 pouces, bénéficie actuellement d'une remise de 54 % chez Rakuten, pour une durée limitée.
Além de uma câmara principal de 200 MP e de uma telefoto periscópica ZEISS APO, o dobrável Vivo X Fold 6 será compatível com um teleconversor, que permite alcançar uma distância focal equivalente até 200 mm.
O novo Mobi Fold, o primeiro rato dobrável da Logitech, acaba de chegar ao mercado. Juntamente com esta solução, que se desliga automaticamente quando dobrado, chega-nos o Spotlight 2, um controlador de apresentações que vai além dos slides com um sistema háptico inédito nesta categoria.
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