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Normal view

A first-in-class pulsatile FXR agonist for bile-acid-related liver diseases

Nature, Published online: 10 June 2026; doi:10.1038/s41586-026-10633-1

Linafexor is a rapidly cleared FXR agonist designed to mimic natural bile acid signalling, achieving transient receptor activation with strong efficacy and reduced toxicity in preclinical and early clinical studies.

Day–night shifts in microbial activity affecting arsenic and iron in the rice rhizosphere

4 June 2026 at 01:00

Nature Geoscience, Published online: 04 June 2026; doi:10.1038/s41561-026-01999-y

Diurnal cycles in microbial reducer activity reveal synchronized mobilization of arsenic and iron in the rice rhizosphere, as shown by metatranscriptomic and biogeochemical analyses.

Viral mediation of anaerobic methane oxidation to carbon sequestration in paddy soil

25 May 2026 at 01:00

Nature Geoscience, Published online: 25 May 2026; doi:10.1038/s41561-026-01998-z

Soil viruses greatly influence the carbon sequestration processes associated with anaerobic methane oxidation, according to analyses of carbon flows in paddy soil.
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