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Efficient and precise programmable DNA knock-in without double-strand breaks

22 July 2026 at 01:00

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10819-7

Kilobase-scale nickase-targeting (KNIT) editing enables single-nick-based DNA insertion across genomic loci and cell types, supporting insertion of DNA fragments exceeding 10 kb, with high efficiency and minimal unwanted off-target effects.

Mitigation of hydrogen crossover in liquid alkaline water electrolysers using gas recombination catalysts

Nature Energy, Published online: 26 June 2026; doi:10.1038/s41560-026-02094-7

Alkaline water electrolysers are being optimized for higher performance, but measures such as advanced electrodes or thinner separators can increase hydrogen crossover and safety risks. Here the authors analyse crossover behaviour and show that a gas recombination catalyst cuts crossover by 95% without affecting electrolyser performance.
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