Apple is preparing for a major expansion of device financing with the upcoming “Apple Upgrade” leasing program — and iOS 27 already contains the tools to enforce it. Code discovered in the beta reveals a new “Restricted Mode” that can limit access to most apps and services on leased iPhones if payments fall behind, while preserving essential functions like Phone, Settings, and Health. Paired with a new “Partner Finance Lock,” this system gives financing partners powerful remote controls without handing over location data.
As Apple partners with Klarna to make iPhones and other devices more affordable through longer-term leases, these findings show exactly how the company plans to protect itself from defaults.
9to5Mac can now confirm that code found in the iOS 27 beta appears to reveal a broader system for managing a financed iPhone, including the ability to restrict apps and services when payments are missed…
If the contract is no longer in good standing, Apple’s system services can place the iPhone in “Restricted Mode,” which blocks access to most apps until the payment or contract issue is resolved, while keeping a small set of apps available…
The code does not appear to cancel, suspend, or otherwise modify App Store subscriptions associated with blocked apps. As a result, a subscription could continue billing even while access to its app is restricted.
Additionally, there isn’t a fixed number of missed payments that automatically triggers the restrictions. The financing provider’s app decides when to lock the device based on its own policies.
Finally, the new framework also introduces a new type of activation lock called “Partner Finance Lock,” which is meant to prevent users from erasing, reselling, or stripping a restricted device for parts.
MacDailyNews Take: It makes perfect sense for Apple to have digital repossession capabilities for leased devices which, after all, users do not own until they are fully paid off.
If you don’t like this financing setup, buy your Apple hardware outright like normal people with basic financial sense.
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In what marks one of its most significant retail model overhauls in years, Apple is preparing to roll out a broad new device leasing initiative called “Apple Upgrade” on July 28th.
Partnering with Swedish financial tech company Klarna Group Plc, the tech giant will allow U.S. customers to lease most models of iPhones, Macs, iPads, and Apple Watches with low monthly installments, expanding hardware subscriptions far beyond its traditional phone-only offerings.
Key Details of the ‘Apple Upgrade’ Program
• Partner Bank: Klarna Group Plc (soft credit check required)
• Supported Hardware: Select iPhones, Macs, iPads, and Apple Watches
• End-of-Term Options: Upgrade early, pay off balance to own, continue monthly payments, or return device
• Notable Exclusions: Apple Watch SE, entry-level iPad, iPhone 16, MacBook Neo
• Protection Plan: AppleCare+ not bundled (available as an optional add-on)
A Broader Reach Across Apple’s Hardware Ecosystem
For over a decade, Apple’s hardware installment options were anchored by its legacy iPhone Upgrade Program, launched in September 2015 in partnership with Citizens Bank. However, that program was restricted strictly to iPhones and bundled AppleCare+ into every plan.
Under the new arrangement with Klarna, Apple aims to address softening hardware demand and recent supply-chain cost spikes by softening the upfront price tag across almost its entire lineup. Customers will no longer be limited to mobile devices; for the first time, high-end MacBooks and iPads can be structured as multi-year leases directly through Apple Stores and the Apple Online Store.
Trade-Offs and Exclusions
While the new leasing options make expensive hardware more accessible, the service is said to come with a few notable catches:
• No Bundled AppleCare+: Unlike the legacy iPhone Upgrade Program, base monthly payments on Apple Upgrade will only cover the hardware cost. Users wanting theft, loss, or damage coverage must purchase AppleCare+ separately.
• Entry-Level Exclusion: According to reports, Apple is intentionally excluding lower-priced budget devices—such as the Apple Watch SE, base-model iPad, older-generation iPhone 16, and MacBook Neo—to encourage buyers toward mid- and high-tier hardware.
• Sunsetting the Old Guard: With Apple Upgrade launching, Apple plans to stop accepting new enrollments for the original iPhone Upgrade Program, though existing members will be permitted to complete their current terms.
MacDailyNews Take: The new program arrives at a critical moment as average selling prices for consumer tech continue to rise. By framing flagship hardware purchases as digestible monthly subscriptions, Apple hopes to keep ecosystem upgrades steady despite broader macroeconomic pressures. Shifting the financing backend to a third-party partner like Klarna allows Apple to expand leasing across nearly its entire hardware portfolio without taking the credit risk directly onto its own balance sheet.
Please help support MacDailyNews — and enjoy subscriber-only articles, comments, chat, and more — by subscribing to our Substack: macdailynews.substack.com. Thank you!
Apple is set to roll out a major new device financing program called “Apple Upgrade,” partnering with Swedish fintech Klarna Group Plc, in a significant new option for Apple hardware customers.
The program, scheduled to launch on July 28th, will allow U.S. customers to lease most models of iPhones, Macs, iPads, and Apple Watches through Apple Stores and online. It requires only a simple credit check and is designed to address softening demand and higher device prices by offering more affordable monthly payments.
Bloomberg News reports that according to people familiar with the matter, Apple Upgrade marks one of the biggest changes to the company’s sales model in years. Lease terms will be 24 months for iPhones and Apple Watches, and 36 months for Macs and iPads. Customers will have flexibility at the end of the term: upgrade to a newer device early, pay off the balance to own it outright, keep making payments, or return the device.
The initiative builds on — and in many ways replaces — Apple’s existing iPhone Upgrade Program. By working with Klarna as the financial backer, Apple aims to spur sales without directly shouldering the full credit risk, while making premium devices more attainable as average selling prices continue to climb.
Notable details and limitations include:
• AppleCare+ is not included in the base lease (customers can add it separately).
• Certain newer models, such as the iPhone 16 series, may initially be excluded.
• Availability is currently limited to the U.S. market.
Consumer reactions have been mixed. Proponents see it as a convenient way to stay on the cutting edge of Apple’s ecosystem with lower upfront costs, while critics worry it could encourage perpetual leasing over ownership and increase long-term spending for users who frequently upgrade.
This move comes as Apple faces pressure to innovate its services and hardware sales amid a competitive landscape and macroeconomic challenges. The partnership with Klarna, known for its “buy now, pay later” services, could also expand into broader financing options in the future.
MacDailyNews Take: The program comes on the heels of recent price increases across iPad and Mac lines driven by component cost inflation, aiming to keep monthly friction low for consumers even as average selling prices rise. Shifting the financing backend to Klarna allows Apple to expand leasing across nearly its entire hardware portfolio without carrying credit risk on its own balance sheet.
The news has boosted AAPL shares into the green.
Please help support MacDailyNews — and enjoy subscriber-only articles, comments, chat, and more — by subscribing to our Substack: macdailynews.substack.com. Thank you!
Os novos dobráveis chegam meses antes de a Apple alegadamente adentrar nesse segmento do mercado com o famigerado “iPhone Ultra” — logo, as apostas da gigante sul-coreana baterão de frente com o futuro dispositivo da Maçã.
Sem mais delongas, vamos conferir os detalhes de cada anúncio abaixo!
Galaxy Z Fold8
Divulgação/Samsung
Agora que os dobráveis da Samsung possuem três variantes, o Z Fold tradicional passou por um reposicionamento, tornando-se talvez a adição mais diferente dentre toda a linha de novos produtos anunciados.
Seu grande destaque é a reformulação no design, adotando um formato que se convencionou chamar de “passaporte”, com uma proporção maior do que aquilo que foi estabelecido nas últimas gerações do dobrável principal da Samsung. Isso resultou em uma tela externa de 5,5 polegadas e aspect ratio de 10:16, além de uma principal de 7,6″ e proporção de 4:3 — especificações bem semelhantes ao que se especula sobre o “iPhone Ultra” —, ambas com taxas de atualização de até 120Hz.
A sul-coreana destacou ainda o peso do modelo, sendo o celular dobrável mais leve já lançado por ela até agora (201 gramas, para ser exato).
Uma das principais diferenças do modelo em relação ao Z Fold8 Ultra está nas câmeras: o modelo padrão conta apenas com duas lentes traseiras (um sensor principal e uma lente ultra-angular, ambos com 50 megapixels), além dos 200mAh de diferença na bateria (4.800mAh no caso do Z Fold8 e 5.000mAh no caso do Z Fold8 Ultra). A linha também marca a estreia das baterias de silício-carbono nos celulares da fabricante.
Quanto ao restante das suas especificações técnicas, destaca-se pela implementação da tecnologia Flex Titanium — baseada em alumínio — para a resistência da tela, a presença do chip Snapdragon 8 Elite Gen 5, opções a partir de 12GB de memória e 256GB de armazenamento (até 1TB), resistência IP48 contra água e poeira, além de suporte ao carregamento de 45W com fio e 15W sem fio. Assim como os demais aparelhos, ele chega com o Android 17 e a One UI 9.
Nos Estados Unidos, ele chega a partir de US$1.900 (US$200 a menos que o Z Fold8 Ultra e US$100 a menos que o Z Fold7) nas cores preta, branca, lavanda e verde pistache (esta última exclusiva para compra no site oficial da Samsung).
Galaxy Z Fold8 Ultra
Divulgação/Samsung
Para os entusiastas do tradicional formato dos dobráveis da Samsung, a melhor opção é o modelo Ultra. Ele conta com as mesmas 8″ na tela principal e 6,5″ na tela externa do Z Fold7, com aspect ratios de 3:2 e 21:9, respectivamente.
Outra diferença notável em relação ao modelo menor é a presença da lente teleobjetiva de 10MP, aos moldes da presente no Z Fold7.
Como citado anteriormente, o aparelho conta com uma bateria de 5.000mAh de silício-carbono, além de compartilhar o Snapdragon 8 Elite Gen 5, as mesmas opções de memória/armazenamento, a resistência IP48 e o suporte aos 45W de carregamento com fio e 15W sem fio do Z Fold8.
Um de seus maiores destaques (nesse caso, negativo) é o preço: US$2.100 — um aumento em comparação ao modelo equivalente da geração passada (vale lembrar, o Z Fold7 chegou por US$2.000 lá fora). Ele está disponível nas cores preta, branca, roxo escuro e verde escuro (esta última exclusiva para compra no site oficial da Samsung).
Galaxy Z Flip8
Divulgação/Samsung
Modelo mais básico da nova linha, o Z Flip8 se destaca pela redução na espessura (13,1mm dobrado contra os 13,7mm do antecessor) e no peso (188g contra 180g do Z Flip7), possibilitando o que a Samsung chama de “uma experiência cotidiana sem vinco”.
Ele conta com uma tela interna de 6,9″, enquanto a externa tem 4,1″, com proporções de 22:9 e 1:1, respectivamente, e suporte a taxas de atualização de 120Hz em ambas. O aparelho chega com um conjunto duplo de câmeras, sendo a lente principal de 50MP, um sensor ultra-angular de 12MP e câmera frontal de 10MP.
Ele chega com o processador Exynos 2600, resistência IP48, 12GB de memória e opções de armazenamento de 256GB e 512GB. Em termos de bateria e recarga, o componente de silício-carbono possui uma capacidade de 4.300mAh, carregamento de até 25W por fio e 15W sem fio.
O Z Flip8 custa US$1.200 (um aumento de US$100 em relação ao Z Flip7) e está disponível nas cores azul, preta, vermelha coral e menta (esta última exclusiva para compra no site oficial da Samsung).
Galaxy Watch9 e Ultra2
Ambos os modelos ganharam suporte ao recurso “levante para falar”, que aciona de imediato o Gemini do Google sem a necessidade de toque ou botão. Os dois relógios contam com o Wear OS 7 e a One UI 9 Watch, compatíveis com smartphones que possuam Android 13 ou superior.
Divulgação/Samsung
Com especificações e design um tanto semelhantes ao seu antecessor, as grandes novidades do Galaxy Watch9 incluem a ampliação de bateria (o modelo de 40mm ganhou um aumento de quase 20%, com 390mAh, enquanto a versão de 44mm possui 445hmAh), a pulseira com design Air Pocket (até 25% mais leve que a presente no Watch8) e a estreia do processador Snapdragon Wear Elite.
Ele continua com as opções de 2GB de memória e 32GB de armazenamento e está disponível em caixas de 40mm e 44mm, nas cores preto e creme, custando a partir de US$380 (um aumento de US$30 em relação ao Watch8).
Já o Galaxy Watch Ultra2 adota uma reformulação na identidade visual que o aproxima do restante da linha, sendo até 12% mais fino que o seu antecessor, mantendo a bateria de 800mAh. A tela também ganhou melhorias, contando com 5.000 nits de brilho máximo.
Para experiências aquáticas, o Ultra2 atende o padrão EN13319 para mergulho e possui certificação IP69K. Além disso, o app Marz deverá receber suporte à metrificação de velocidades e orientações de descompressão.
Disponível nas cores titânio preto e titânio prata, o modelo está disponível a partir de US$700, um aumento de US$50 em relação à primeira geração.
Inteligência artificial
Durante o evento, a Samsung reforçou sua ciência e presença quanto às IAs agênticas, expandindo a experiência para além das telas dos smartphones e passando a oferecer assistência contínua de IA em tempo real nos dispositivos do seu ecossistema; o foco da Samsung é a entrega da experiência hands-free (ou seja, mãos livres). Ela afirmou ainda que essa integração contará com mecanismos de proteção e segurança, embora não tenha adentrado em detalhes técnicos de como fará isso.
A empresa também mencionou a integração de dados biométricos coletados pelos Galaxy Watch ao fluxo de trabalho médico, focada na prevenção de riscos de saúde com o auxílio da inteligência artificial (IA), permitindo a sugestão de refeições e treinos adaptados com base em interpretações de biossinais.
Preço e disponibilidade
Os novos smartphones chegarão ao Brasil no dia 6 de agosto, mas ainda não tiveram seus preços divulgados; ainda assim, a Samsung já antecipou que a aquisição de algum dos dispositivos durante a pré-venda garantirá até seis meses de Google AI Pro sem custos adicionais.
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Mercurio y plata mezclados en una fina capa: así falsificaban monedas en el siglo XV. Un estudio con tecnología de sincrotrón aplicado a los materiales hallados en el castillo italiano de Godano lo confirma.
Controlling ribosomal RNA could help researchers target diseases driven by too little or too much protein production. Cells do not simply make proteins at a fixed pace. They continually adjust production to match their needs, and those changes can help determine whether a cell keeps dividing, adopts a specialized identity, or retains the developmental flexibility [...]
Un retrato oculto durante casi cuatro siglos revela cómo Velázquez retrató el poder militar de Olivares en plena crisis diplomática con Roma. Técnica, diplomacia y ambición se cruzan en un cuadro que reescribe el catálogo del pintor.
Independent advisors for the Food and Drug Administration on Friday voted 9–0 in support of approving Moderna's seasonal mRNA flu vaccine, which a Trump appointee at the agency initially tried to block from even being reviewed.
In an all-day meeting, members of the FDA's advisory committee—known as VRBPAC for Vaccines and Related Biological Products Advisory Committee—pored over data and presentations on the vaccine, which is dubbed mRNA-1010 and branded as mFlusiva. The presentations included a review from FDA scientists, which was supportive of the vaccine.
Data from a Phase 3 trial including over 40,000 adults age 50 and older found the mRNA vaccine was around 27 percent more effective against seasonal flu than a standard flu shot. A smaller Phase 3 trial, involving data from nearly 3,000 people age 65 years and older, showed the shot produces stronger immune responses than a high-dose flu vaccine, which is recommended for this age group. The safety profile of the vaccine was also generally good.
In a groundbreaking advancement that could reshape the landscape of molecular biology, researchers have unveiled a high-resolution method for single-cell sequencing of trans-spliced mRNA, setting new benchmarks in cellular transcriptomics. This state-of-the-art technique, detailed in a recent publication by Cosentino and colleagues, promises unprecedented insight into the complex mechanisms governing RNA splicing and gene expression at a single-cell level, a domain critical for understanding diverse biological processes and disease states.
Traditional RNA sequencing methods often struggle to capture the nuances of trans-splicing—an RNA processing event where exons from different pre-mRNA molecules are joined together. This unique form of splicing has been relatively underexplored, largely due to technical limitations in distinguishing trans-spliced variants from the more common cis-spliced transcripts. The innovation presented in this protocol addresses these challenges head-on by incorporating enhanced molecular tagging and amplification strategies to faithfully preserve the native architecture of trans-spliced mRNAs.
The power of single-cell sequencing lies in its ability to discern cellular heterogeneity that bulk sequencing methods average out. By applying this resolution to trans-splicing events, the new protocol enables researchers to map how individual cells harness this process to diversify their transcriptomes. This can reveal regulatory layers previously masked in population-level analyses, providing clues about cell type-specific functions, developmental trajectories, and responses to environmental stimuli.
Central to the protocol’s success is its meticulous capture of the transcript’s 5’ and 3’ ends, allowing unambiguous identification of trans-spliced junctions. The approach leverages novel enzymatic reactions and ligation steps carefully optimized to maintain sequence integrity, enabling high-fidelity reconstruction of splicing landscapes. Moreover, the method integrates seamlessly with established single-cell RNA sequencing platforms, widening accessibility and potential for widespread adoption.
The practical implications of this development are vast. Researchers can now probe the role of trans-splicing in normal physiology and pathogenesis with precision. Given that aberrant RNA splicing is implicated in various cancers and genetic disorders, understanding trans-splicing patterns at the single-cell level could illuminate new biomarkers and therapeutic targets. Furthermore, tissues with complex cell compositions, such as the brain or immune system, stand to benefit profoundly from this refined analytical lens.
Implementing this protocol requires meticulous experimental execution. Steps include cell isolation, mRNA extraction under conditions preserving RNA integrity, strategic reverse transcription with specialized primers, as well as a series of purification and amplification cycles designed to enrich for trans-spliced sequences. Each phase has been rigorously characterized to maximize sensitivity and specificity, ensuring reproducible outcomes across diverse sample types.
Bioinformatic analysis pipelines accompanying the protocol are equally sophisticated. They employ advanced algorithms capable of distinguishing genuine trans-splicing events from experimental artifacts or sequencing errors. These computational tools facilitate high-confidence annotation of transcripts, visualization of splicing diversity, and quantification of junction abundance at single-cell resolution, pushing the analytical frontier forward.
Beyond capturing static snapshots, the technology opens pathways to dynamic studies. Scientists can track how trans-splicing activity varies during cellular differentiation, in response to external cues, or throughout disease progression. This temporal dimension adds a vital layer of understanding to RNA biology’s functional repertoire, potentially revealing regulatory checkpoints amenable to therapeutic modulation.
The introduction of this high-resolution sequencing method also underscores the increasing convergence of experimental and computational biology. It reflects a growing recognition that unraveling complex molecular phenomena demands integrated approaches combining cutting-edge laboratory techniques with robust data science. This synergy not only accelerates discovery but democratizes access to intricate biological insights.
Intriguingly, this approach may shed light on evolutionary aspects of splicing. Differences in trans-splicing prevalence and patterns across species and cell types could inform hypotheses about RNA processing’s adaptive significance. Delineating these evolutionary narratives may provide broader context for interpreting functional data and guiding synthetic biology applications.
Moreover, the methodology’s adaptability hints at future expansions. For example, coupling this protocol with spatial transcriptomics could map trans-spliced mRNAs within tissue architecture, or integrating with proteomics could link transcript variants to protein isoform expression. Such multidimensional analyses hold promise for unraveling the intricate web connecting genotype to phenotype.
As research workflows adopt this technology, anticipated challenges include managing increased data complexity and scaling up throughput for large single-cell atlases. Nonetheless, the benefits—unveiling the hidden layers of transcriptomic regulation with unprecedented clarity—far outweigh these hurdles. The authors’ thorough validation in diverse biological contexts allays concerns about adaptability and robustness.
Ultimately, this state-of-the-art protocol propels trans-splicing research to new heights, furnishing the scientific community with a versatile toolset to decode RNA’s role in health and disease at unparalleled resolution. It exemplifies a milestone where technological ingenuity meets biological inquiry, heralding a new era in transcriptomic sciences.
As this methodology gains traction, it is poised to catalyze transformative discoveries, deepen our molecular understanding, and inspire follow-up innovations. The potential ripple effects extend from basic science to clinical diagnostics, underlining the enduring impact of pioneering single-cell approaches in unlocking cellular complexity comprehensively.
Subject of Research: High-resolution single-cell sequencing of trans-spliced mRNA
Article Title: High-resolution single-cell sequencing of trans-spliced mRNA
Article References:
Cosentino, R.O., Keneskhanova, Z., Esser, S. et al. High-resolution single-cell sequencing of trans-spliced mRNA. Nat Protoc (2026). https://doi.org/10.1038/s41596-026-01373-7
A new ultra-efficient DNA splicing method developed by a Japanese research team using silver nanoparticles offers a dramatic improvement to how scientists stitch genetic blueprints together, with implications for future developments in genetics.
In animal models for drug research, crop breeding, and disease treatment, scientists cut and recombine DNA segments, traditionally relying on “sticky ends,” the overhanging bits left at the ends of the sequences to create a stable join.
Now, researchers at Japan’s Nagoya University and Gifu University have announced a much more precise silver nanoparticle-based solution for DNA cutting and joining in a recent paper published in Nucleic Acids Research, enabling incredible precision.
DNA Splicing Challenges
The sticky ends required in traditional splicing techniques come with significant drawbacks. In these methods, restriction enzymes cut DNA, which is then reattached using T4 DNA ligase. Unfortunately, restriction enzymes lack precision, often producing sticky ends that are not long enough to create an optimal join.
Professor Hiroshi Abe and Assistant Professor Masahito Inagaki at Nagoya University, in collaboration with Professor Natsuhisa Oka at Gifu University, led the effort to improve the efficiency of DNA splicing. The team focused on cutting DNA segments using chemical reactions rather than the restriction enzymes typically employed, drawing inspiration from decades-old research.
Between 1990 and 1992, researchers reported successfully cutting 3′-thiol-modified DNA at specific locations using silver ions.
“Although it had been known for a long time, it was never put to practical use, and we recognized that it could be the key to our goal of creating sticky ends of any length and sequence at any position we choose,” Hiroshi told The Debrief.
Rethinking Old Work
However, this method was impractical because nonspecific binding of silver ions resulted in only a 14% recovery rate.’ The researchers’ breakthrough came from substituting silver nanoparticles for silver ions, aiming to improve DNA recovery by removing them via centrifugation after the reaction was over.
“The turning point was to turn this problem of ‘how to remove the silver’ to our advantage,” Hiroshi explained. “We reasoned that if the silver were in the form of nanoparticles, it could be removed easily by centrifugation after the reaction, greatly improving recovery.”
Another problem quickly arose, as cleaving efficiency required temperatures and durations that were hazardous to the DNA itself. At 70°C, the DNA achieved only 50% efficiency, whereas it took 2 hours at 95°C to reach something approaching 100% efficiency.
Polyethylene glycol (PEG), a water-soluble polymer, provided the solution the researchers required. Coating the silver nanoparticles with PEG increased efficiency at a mere 37°C for two hours, from 36% to 92%.
“In the end, we optimized the conditions to a practical level and, under ambient temperatures, achieved PEG-modified cleaving efficiency above 91% at 50°C within just one to two hours,” Inagaki said.
A Powerful DNA Editing Breakthrough
The new silver nanoparticle technique improves DNA assembly efficiency by two to five times. Crucially, their work is not theoretical: the team successfully introduced a DNA fragment into live cells, confirming expression of a green fluorescent protein gene.
“We have shown that two DNA fragments can be joined. Now, we need to confirm whether multiple fragments can be joined at the same time—a key step for building genome-scale DNA,” Ingaki said.
The researchers will continue to pursue this new splicing method, both to explore its potential for advanced applications and to consider bringing the technique into routine use.
“To make it a routine, everyday tool, the remaining tasks are to verify reproducibility across a wide range of sequences, to scale up to longer DNA, and to develop standardized, kit-format protocols that anyone can follow,” Hiroshi said. “We see these as engineering and optimization challenges rather than fundamental barriers, and we believe they can be overcome.”
“Our next goal is to extend this technique to longer DNA and, ultimately, to genome-scale DNA assembly,” Hiroshi concluded. “Specifically, we plan to apply it to the construction of mRNA libraries and the synthesis of long-chain DNA encoding therapeutic proteins, while also working on automation and standardization, so that it can grow into a foundational technology actually used in the fields of synthetic biology and nucleic acid medicine.”
Ryan Whalen covers science and technology for The Debrief. He holds an MA in History and a Master of Library and Information Science with a certificate in Data Science. He can be contacted at ryan@thedebrief.org, and follow him on Twitter @mdntwvlf.
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