Researchers have identified and formally described a new species of the African monkey genus Colobus living in the remote interior of the Democratic Republic of Congo, marking only the fifth new monkey species found on the continent in the past 75 years.
The post Scientists Discover New Monkey Species in Democratic Republic of Congo appeared first on Sci.News: Breaking Science News.
Silver nanoparticles provide a more efficient way to cut and assemble DNA, improving recovery rates and boosting DNA joining efficiency for future gene engineering applications. DNA is made of long chains that carry the instructions living things need to grow and function. In genetic engineering, researchers cut DNA at chosen locations and attach the pieces [...]
A longstanding archaeological mystery has loomed over discoveries at ancient burial sites in eastern Siberia: why were so many children and adolescents among the dead?
Now, according to a recent study in the journal Nature, DNA recovered from human remains found in burial sites at four cemeteries near Lake Baikal in eastern Siberia may finally reveal the answer.
Thousands of years ago, prior to the rise of ancient medieval cities—and their often-rat-infested streets—a disease famously associated with these rodents had already ravaged communities of prehistoric hunter-gatherers.
The research, based on reconstructions of ancient bacterial genomes preserved in the teeth of these ancient Siberians, revealed the presence of previously unknown strains of Yersinia pestis—the bacteria responsible for plague—providing fresh evidence that the lethal disease was already manifesting and killing human populations at least as far back as 5,500 years ago.
“Whether the earliest forms of plague were mild or virulent has been a matter of debate, but our findings demonstrate that these ancient strains were already highly lethal,” said senior author Eske Willerslev of the University of Copenhagen and the University of Cambridge.
In their study, the team successfully located plague DNA in 18 out of 46 individuals they studied. Based on radiocarbon dating, many of the deaths were confirmed to have all happened within a short span of time, which is consistent with sudden deaths resulting from plague. Additionally, genetic evidence showed that several of these victims had been close relatives.
One key finding in the research involved the number of children and adolescents who were among the dead—a discovery mirroring earlier findings at prehistoric sites in the region, which had remained a longstanding archaeological mystery.
“The unusually high number of children and the short timespan was a real puzzle that we’ve been trying to solve since the 1990s,” said archaeologist Andrzej Weber of the University of Alberta. “Finding out that plague was the cause is extraordinary, but it makes so much sense.”
Based on the new findings, ancient strains of plague appear to have been more harmful than once thought. In the past, it was presumed that because these early strains lacked genetic adaptations that helped the bubonic plague spread so efficiently through fleas and rodents, they were relatively harmless.
The team’s research now reveals that these newly identified strains carried a specific toxin-producing genetic feature, known as a superantigen, which can trigger severe immune responses that potentially had devastating impacts on mortality rates in the ancient world.
Such deadly outbreaks may have had a far more significant impact on ancient human populations than previously realized, and during periods long before the rise of major urban centers and organized agriculture.
In terms of the origins of the disease, researchers believe that they may have finally traced it to Central or Northeast Asia, where infections may have spread from marmots, large rodents that are still recognized as plague carriers in modern times.
After years of uncertainty, the team’s research offers some of the best evidence to-date that one of the most devastating diseases in human history was already playing a role in shaping human history thousands of years earlier than once thought.
Martin Sikora, associate professor at the University of Copenhagen and the study’s senior author, says his team’s research “changes our understanding of the earliest plague outbreak,” and now confirms that such ancient strains “appear to have carried a potent combination of virulence factors that could make infection highly lethal.”
The team’s study, “Lethal plague outbreaks in Lake Baikal hunter-gatherers 5,500 years ago,” appeared in the journal Nature on June 17, 2026.
Micah Hanks is the Editor-in-Chief and Co-Founder of The Debrief. A longtime reporter on science, defense, and technology with a focus on space and astronomy, he can be reached at micah@thedebrief.org. Follow him on X @MicahHanks, and at micahhanks.com.
A genetic study of 2,000-year-old grape seeds is shedding new light on ancient winemaking. For centuries, the vineyards of Tuscany have been associated with some of the world’s most celebrated red wines. But a cache of grape seeds buried in ancient wells is revealing a very different story about what people were growing and drinking [...]
Have you ever considered buying a DNA kit for a family member as a special gift, such as Father’s Day? On the surface, it may seem like a good idea, as it allows loved ones or friends to peer into their past and family history; however, psychologists have recently warned against it, as it might have profound psychological implications.
In a new book titled The Psychology of Genealogy, Dr. Susan Moore, a retired Australian university researcher in social and developmental psychology, examines the complex emotions associated with DNA testing and uses real-life case studies to illustrate its psychological impact.
“Should you give DNA kits as gifts? It can be fun, [but] it can be risky,” Moore says in a statement.
Moore cautions that the psychological impact of DNA testing may be far greater than many people anticipate. These tests can reveal unexpected family secrets, uncover cases of misattributed paternity, disclose donor conception, and even link individuals to hundreds of previously unknown half-siblings or relatives they may not want to be connected with.
“Do first think carefully about how your intended recipient might cope with unexpected outcomes,” Moore says.
“Hobbyist family historians are uncovering joyful and inspiring stories of the past as well as sad and unsettling secrets of their ancestry,” Moore explains. “Records and DNA matches provide boosts, challenges, and even threats to one’s sense of self, and this is occurring at unprecedented levels.”
Unexpected DNA results can deeply impact a person’s sense of self and identity, along with family belonging and dynamics—a phenomenon psychologists call “identity disruption.” Moore’s book highlights cases involving revelations of misattributed parentage, late-discovered adoption, and donor conception uncovered through genetic testing, all of which caused more physical harm than good.
“At the personal level, these may be findings that cause you great distress, that destabilize your sense of who you are, that initially at least, you would have preferred not to know. Once known, however, they cannot be unknown,” says Moore.
DNA testing has also raised privacy concerns in recent years. A 2023 23andMe data breach exposed millions of users’ genetic information, while financial challenges that DNA companies have faced raise questions about what happens to genetic data if these companies fail.
Surprising statistics show that, presently, over 30 million people have tested their DNA through genealogical services like 23andMe and AncestryDNA.
Still, for many people, even with data breaches and larger companies buying up DNA data sets, it’s still enticing to buy, as their curiosity seems to outweigh the risks.
“How exciting it can be to discover the identity of an ancestor, solve a family mystery, prove or disprove family ‘legends’ or discover previously unknown living relatives,” Moore says.
“Indeed, genealogists regularly report elation and joy as they unearth lost relatives, discover the identity of a ‘missing’ ancestor, or otherwise break down ‘brick walls’ (genealogical puzzles that seem to resist solutions due to missing, inaccurate, or hard-to-access records).”
“Curiosity is a great motivator,” Moore adds.
Chrissy Newton is a PR professional and the founder of VOCAB Communications. She currently appears on The Discovery Channel and Max and hosts the Rebelliously Curious podcast, which can be found on YouTube and on all audio podcast streaming platforms. Follow her on X: @ChrissyNewton, Instagram: @BeingChrissyNewton, and chrissynewton.com. To contact Chrissy with a story, please email chrissy @ thedebrief.org.
Scientists found that some inherited traits can bypass the traditional rules of genetics, revealing a surprising new layer of inheritance beyond DNA. For more than a century, Gregor Mendel’s laws of inheritance have served as the foundation of genetics. But new research suggests that inheritance can be more complicated than the DNA sequences passed from [...]DNA carries the instructions for life, but additional molecular systems help determine how those instructions are used. New research in a sea anemone reveals an unexpected role for one of these systems. DNA is often described as the blueprint of life, but a blueprint is only useful if someone knows how to read it. Across [...]A new long-read DNA test improves rare disease diagnosis, replaces multiple existing tests, and could become the preferred global standard for genetic diagnostics. A new DNA test is providing a far more detailed view of the genome than current standard diagnostic methods, helping doctors identify rare genetic disorders more often. The test can replace up [...]Plague swept through groups of hunter-gatherers in southeastern Siberia 5,500 years ago, leaving dozens dead in its wake—with DNA from Yersinia pestis bacteria still trapped inside their teeth.
University of Oxford ancient DNA researcher Ruairidh Macleod and his colleagues recently sequenced the telltale bacterial DNA in teeth from plague victims at four ancient cemeteries in the area around Russia’s Lake Baikal. The tragedy that befell these communities is now the earliest known plague outbreak, courtesy of the oldest strain of Y. pestis ever sequenced.
Until recently, scientists who study the evolution of diseases have held two fairly solid ideas about the origins of plague, the disease caused by Yersinia pestis bacteria. It's a scourge so awful that it has gone down in history as not just a plague but the plague. The first idea is that the earliest strains didn't have the right genetic traits to be really lethal. And the second is that the plague first began menacing humans when the first farmers settled in densely packed towns alongside rats and domestic animals.
© Kevin WIlson
Plague swept through groups of hunter-gatherers in southeastern Siberia 5,500 years ago, leaving dozens dead in its wake—with DNA from Yersinia pestis bacteria still trapped inside their teeth.
University of Oxford ancient DNA researcher Ruairidh Macleod and his colleagues recently sequenced the telltale bacterial DNA in teeth from plague victims at four ancient cemeteries in the area around Russia’s Lake Baikal. The tragedy that befell these communities is now the earliest known plague outbreak, courtesy of the oldest strain of Y. pestis ever sequenced.
Until recently, scientists who study the evolution of diseases have held two fairly solid ideas about the origins of plague, the disease caused by Yersinia pestis bacteria. It's a scourge so awful that it has gone down in history as not just a plague but the plague. The first idea is that the earliest strains didn't have the right genetic traits to be really lethal. And the second is that the plague first began menacing humans when the first farmers settled in densely packed towns alongside rats and domestic animals.
© Kevin WIlson
Researchers have captured the first atomic-level views of human SMUG1, a key enzyme involved in repairing damaged DNA. Every cell in your body is constantly battling damage to its DNA. Now, scientists have captured the first atomic level images of a key human repair enzyme in action, revealing how cells identify and remove some of [...]
A new ultra-efficient DNA splicing method developed by a Japanese research team using silver nanoparticles offers a dramatic improvement to how scientists stitch genetic blueprints together, with implications for future developments in genetics.
In animal models for drug research, crop breeding, and disease treatment, scientists cut and recombine DNA segments, traditionally relying on “sticky ends,” the overhanging bits left at the ends of the sequences to create a stable join.
Now, researchers at Japan’s Nagoya University and Gifu University have announced a much more precise silver nanoparticle-based solution for DNA cutting and joining in a recent paper published in Nucleic Acids Research, enabling incredible precision.
The sticky ends required in traditional splicing techniques come with significant drawbacks. In these methods, restriction enzymes cut DNA, which is then reattached using T4 DNA ligase. Unfortunately, restriction enzymes lack precision, often producing sticky ends that are not long enough to create an optimal join.
Professor Hiroshi Abe and Assistant Professor Masahito Inagaki at Nagoya University, in collaboration with Professor Natsuhisa Oka at Gifu University, led the effort to improve the efficiency of DNA splicing. The team focused on cutting DNA segments using chemical reactions rather than the restriction enzymes typically employed, drawing inspiration from decades-old research.
Between 1990 and 1992, researchers reported successfully cutting 3′-thiol-modified DNA at specific locations using silver ions.
“Although it had been known for a long time, it was never put to practical use, and we recognized that it could be the key to our goal of creating sticky ends of any length and sequence at any position we choose,” Hiroshi told The Debrief.
However, this method was impractical because nonspecific binding of silver ions resulted in only a 14% recovery rate.’ The researchers’ breakthrough came from substituting silver nanoparticles for silver ions, aiming to improve DNA recovery by removing them via centrifugation after the reaction was over.
“The turning point was to turn this problem of ‘how to remove the silver’ to our advantage,” Hiroshi explained. “We reasoned that if the silver were in the form of nanoparticles, it could be removed easily by centrifugation after the reaction, greatly improving recovery.”
Another problem quickly arose, as cleaving efficiency required temperatures and durations that were hazardous to the DNA itself. At 70°C, the DNA achieved only 50% efficiency, whereas it took 2 hours at 95°C to reach something approaching 100% efficiency.
Polyethylene glycol (PEG), a water-soluble polymer, provided the solution the researchers required. Coating the silver nanoparticles with PEG increased efficiency at a mere 37°C for two hours, from 36% to 92%.
“In the end, we optimized the conditions to a practical level and, under ambient temperatures, achieved PEG-modified cleaving efficiency above 91% at 50°C within just one to two hours,” Inagaki said.
The new silver nanoparticle technique improves DNA assembly efficiency by two to five times. Crucially, their work is not theoretical: the team successfully introduced a DNA fragment into live cells, confirming expression of a green fluorescent protein gene.
“We have shown that two DNA fragments can be joined. Now, we need to confirm whether multiple fragments can be joined at the same time—a key step for building genome-scale DNA,” Ingaki said.
The researchers will continue to pursue this new splicing method, both to explore its potential for advanced applications and to consider bringing the technique into routine use.
“To make it a routine, everyday tool, the remaining tasks are to verify reproducibility across a wide range of sequences, to scale up to longer DNA, and to develop standardized, kit-format protocols that anyone can follow,” Hiroshi said. “We see these as engineering and optimization challenges rather than fundamental barriers, and we believe they can be overcome.”
“Our next goal is to extend this technique to longer DNA and, ultimately, to genome-scale DNA assembly,” Hiroshi concluded. “Specifically, we plan to apply it to the construction of mRNA libraries and the synthesis of long-chain DNA encoding therapeutic proteins, while also working on automation and standardization, so that it can grow into a foundational technology actually used in the fields of synthetic biology and nucleic acid medicine.”
The paper, “Silver Nanoparticle Induced Site-Specific Strand Cleavage of Chemically Modified Oligonucleotides for Long-Chain DNA Assembly,” appeared in Nucleic Acids Research on June 10, 2026.
Ryan Whalen covers science and technology for The Debrief. He holds an MA in History and a Master of Library and Information Science with a certificate in Data Science. He can be contacted at ryan@thedebrief.org, and follow him on Twitter @mdntwvlf.
Two elusive groups of millipedes, Siphoniulida and Siphonocryptida, were the last missing pieces in the evolutionary history of Earth’s oldest land animals, according to a team of entomologists led by Virginia Tech.
The post Entomologists Reconstruct Evolutionary History of Millipedes appeared first on Sci.News: Breaking Science News.
The extinct Eurasian cave lion (Panthera spelaea) and today’s African and Asian lions (Panthera leo) belong to separate evolutionary lineages that diverged roughly 1.7 million years ago -- far earlier than previously thought, according to an analysis of 12 cave lion genomes spanning more than 100,000 years.
The post Study: Cave Lions were Distinct Species that Occasionally Bred with Ancestors of Today’s Lions appeared first on Sci.News: Breaking Science News.
In new research, scientists sequenced and analyzed chromosome-level genomes of the Linnaeus’s two-toed sloth (Choloepus didactylus) and the southern anteater (Tamandua tetradactyla).
The post Secret to Sloths’ Slow Life May Lie in Ancient ‘Jumping Genes’ appeared first on Sci.News: Breaking Science News.
A multidisciplinary study has uncovered new details about a centuries-old burial in northern Finland, revealing genetic links to Sámi populations and evidence of a remarkably mobile life. A new study by the University of Turku and its partners has revealed new details about a man buried near Lake Kitka in Kuusamo, Finland, around the turn [...]Cancer’s most notorious growth protein may also be helping tumors survive chemotherapy. A protein already known for fueling cancer growth may have another troubling ability: helping damaged tumor cells repair their DNA and survive treatments designed to destroy them. Researchers at Oregon Health & Science University (OHSU) report that MYC, a protein that is overactive [...]A new study reveals that an extremely small change in a non-coding region of DNA can dramatically alter how sex develops in mice. How much can a single letter of DNA matter? According to new research from Bar-Ilan University, one misplaced genetic “letter” can completely change the course of sexual development. In a study published [...]
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