By integrating reinforcement learning with quantum error correction, a quantum computer continuously self-calibrates during computation, achieving record logical error rates and enhanced resilience to drift.
Radio-frequency switches made from two-dimensional layered hexagonal boron nitride (hBN) were co-integrated on gallium nitride (GaN) microchips to build programmable millimetre-wave (mmWave) monolithic microwave integrated circuits suitable for 6G hardware.
Viscoelastic phase separation is used to fabricate non-collapsible, air-rich networks in high-water-content hydrogels containing silica aerogel beads, allowing air to permeate through the material and enabling a tenfold increase in oxygen permeability over pristine hydrogels.
The insects could explore underwater for up to three hours. Plus, fake cancer studies rake in the citations and how scientists can build trust by recognizing their biases.
This Perspective examines the challenges and opportunities of genomic sequencing across multiple clinical applications, including genetic therapies, and calls for the establishment of new, centralized reference standards to improve consistency and accuracy in the field of precision medicine.
SyeA was present in the Buchnera ancestor, is secreted into the host cytoplasm, is homologous to secreted effectors of bacterial pathogens and is essential for Buchnera transmission.
An immunopeptidomics analysis identifies numerous Plasmodium T cell antigens that are conserved across malaria parasite species and expressed at several phases of the parasite’s life cycle, with possible applications in the development of a malaria vaccine.
Researchers at the Massachusetts Institute of Technology (MIT) have developed an ultra-efficient computer chip that could help tiny robots and lightweight devices create detailed 3D maps of their surroundings while using very little energy. The new chip could allow small drones to fly through narrow spaces, such as air-conditioning ducts or industrial pipelines, to inspect […]
Chronic dietary cholesterol activates Ral GTPases, which promote LDLR internalization and lysosomal degradation through RalBP1–REPS1 and CTSA, thereby reducing cholesterol clearance, whereas CTSA inhibition restores LDLR function and may offer a therapeutic strategy for cardiovascular disease.
Global high-resolution mapping shows widespread seagrass loss and degradation since 2019, with most meadows outside protected areas, highlighting urgent conservation and climate-policy needs.
Integrated pharmacological, biochemical, biophysical and structural analyses of small-molecule β-arrestin inhibitors show how they block β-arrestin engagement with activated GPCRs, revealing their mechanism of action and uncovering a previously unrecognized allosteric regulatory site.
Researchers have tracked the electrical activity of individual brain cells during conversation in real time. Plus, the history of GPS and a cross-species transplant that could reveal clues about the origin of animals.
Plague swept through groups of hunter-gatherers in southeastern Siberia 5,500 years ago, leaving dozens dead in its wake—with DNA from Yersinia pestis bacteria still trapped inside their teeth.
University of Oxford ancient DNA researcher Ruairidh Macleod and his colleagues recently sequenced the telltale bacterial DNA in teeth from plague victims at four ancient cemeteries in the area around Russia’s Lake Baikal. The tragedy that befell these communities is now the earliest known plague outbreak, courtesy of the oldest strain of Y. pestis ever sequenced.
Unearthing a new backstory for the plague
Until recently, scientists who study the evolution of diseases have held two fairly solid ideas about the origins of plague, the disease caused by Yersinia pestis bacteria. It's a scourge so awful that it has gone down in history as not just a plague but the plague. The first idea is that the earliest strains didn't have the right genetic traits to be really lethal. And the second is that the plague first began menacing humans when the first farmers settled in densely packed towns alongside rats and domestic animals.
Plague swept through groups of hunter-gatherers in southeastern Siberia 5,500 years ago, leaving dozens dead in its wake—with DNA from Yersinia pestis bacteria still trapped inside their teeth.
University of Oxford ancient DNA researcher Ruairidh Macleod and his colleagues recently sequenced the telltale bacterial DNA in teeth from plague victims at four ancient cemeteries in the area around Russia’s Lake Baikal. The tragedy that befell these communities is now the earliest known plague outbreak, courtesy of the oldest strain of Y. pestis ever sequenced.
Unearthing a new backstory for the plague
Until recently, scientists who study the evolution of diseases have held two fairly solid ideas about the origins of plague, the disease caused by Yersinia pestis bacteria. It's a scourge so awful that it has gone down in history as not just a plague but the plague. The first idea is that the earliest strains didn't have the right genetic traits to be really lethal. And the second is that the plague first began menacing humans when the first farmers settled in densely packed towns alongside rats and domestic animals.
Heat flux across the core–mantle boundary is laterally variable, and heat may flow into the core beneath hot piles of dense material such as large low-shear-wave-velocity provinces, according to mantle thermochemical convection models.
A prototype differential atom interferometer operates at the standard quantum limit with no excess noise beyond atom shot noise, achieving performance in line with the specifications for future long-baseline atom interferometers.
The Pakistan Genome Resource compiles biobank data from 173,303 individuals with high familial relatedness, broadening the catalogue of human genetic variation and establishing a population-specific genomic reference for Pakistan.