❌

Normal view

OU Researchers Enhance Imaging Technology for Better Donor Liver Assessment

9 July 2026 at 06:00

A groundbreaking imaging technology developed by researchers at the University of Oklahoma promises to revolutionize liver transplant evaluations by enabling more comprehensive and rapid assessments of donor organ health. With thousands of patients awaiting liver transplants nationwide, transplant teams urgently need tools that can deliver swift, accurate insights without invasive procedures. The team, led by Dr. Qinggong Tang, has adapted polarization-sensitive optical coherence tomography (PS-OCT)—an advanced imaging modality originally utilized in retinal scans—to noninvasively evaluate donor livers at high resolution.

Traditional liver assessments rely heavily on biopsies, where small tissue samples are extracted and examined for signs of disease or damage. While considered the gold standard, biopsies are inherently limited, providing only a microscopic snapshot of a vast organ that may vary in condition. This narrow sampling can cause uncertainty, sometimes leading to the discard of viable organs. The OU team sought to overcome these limitations by employing PS-OCT, which not only captures detailed cross-sectional images of liver tissue but also measures its polarization properties, revealing subtle structural and biochemical features linked to liver health.

The engineers designed a portable PS-OCT system optimized for clinical and operating room environments, allowing transplant teams to scan liver surfaces quickly and noninvasively. The imaging data are then analyzed using advanced artificial intelligence algorithms, co-developed with Dr. Chongle Pan’s computer science lab. These AI tools quantify critical parameters indicative of hepatic steatosis (fat accumulation) and inflammation, two primary factors influencing liver viability. By training their models on datasets from over thirty clinical cases—comparing PS-OCT results with biopsy outcomes and post-transplant organ function—the researchers demonstrated strong correlations between imaging biomarkers and actual clinical metrics.

Beyond providing a more holistic view of donor liver condition, PS-OCT could enhance decision-making speed, potentially expanding the pool of organs deemed suitable for transplantation by identifying healthy tissue regions missed by biopsy. Such improvements may reduce organ discard rates and improve transplant success. Encouraged by initial findings, the OU team plans a large multisite clinical trial involving institutions like UT Southwestern and the Cleveland Clinic to validate and refine this approach across diverse patient populations.

This work exemplifies OU’s interdisciplinary innovation platform that integrates optical bioimaging, machine learning, pathology, and organ perfusion technology to translate engineering advances directly into clinical practice. The researchers also intend to extend PS-OCT evaluation methods to other organs, including kidneys and lungs, widening the impact of this technology.

Supported by National Science Foundation grants and institutional partnerships, the team’s efforts mark a significant step toward redefining how transplanted organs are assessed. Dr. Tang emphasizes that this is just the beginning, envisioning a future where noninvasive, AI-enhanced imaging facilitates safer, faster, and more effective organ transplantation worldwide.


Subject of Research: Donor liver evaluation using advanced imaging techniques
Article Title: Human donor liver viability evaluation with polarization-sensitive optical coherence tomography
News Publication Date: 24-Jun-2026
Web References: http://dx.doi.org/10.1126/scitranslmed.adv7124
Image Credits: University of Oklahoma / Ellie Pinter

Keywords

Organ transplantation, Optical coherence tomography, Polarization-sensitive imaging, Liver viability, Artificial intelligence, Biomedical imaging, Noninvasive diagnostics, Medical innovation

Using Visual Studio Code’s ‘air-gapped’ AI model mode

24 June 2026 at 10:00

Microsoft has been pushing hard to make Visual Studio Code a major way to consume its AI services, mostly in the form of GitHub Copilot. GitHub Copilot’s deep integration with VS Code brings many conveniences — inline autocomplete, for instance — but it’s frustrating for those, like me, who would rather use another model provider, or even a locally hosted LLM, for those functions.

Visual Studio Code 1.122 introduced a new feature, “Use BYOK [Bring Your Own Key] without a GitHub sign-in,” that allows you to “use chat, tools, and MCP servers in air-gapped or restricted environments where GitHub sign-in isn’t possible.” More importantly, it “enables fully offline workflows with local models like Ollama.”

In other words, you can now use locally hosted LLMs for chat, tools, and Model Context Protocol servers inside Visual Studio Code. The one thing you still can’t do is use a local LLM for inline and next-edit suggestions — at least, not without additional tooling.

Choosing a model for BYOK mode

If you want to use a local LLM with VS Code’s bring-your-own-model system, the first thing you need is a way to host the model. VS Code lacks a model-hosting mechanism of its own, although it’s conceivable that a VS Code extension may offer something like that in the future. That said, hosting models is complicated enough that a dedicated app is really needed for the job.

One easy way to host models is via a product like LM Studio, a convenient GUI for standing up, serving, and managing LLMs on one’s own hardware. The model host does not have to be the same system you run VS Code on, either. It can be on a server box you control, or on a cloud instance.

The choice of model is also important. Many models are powerful but won’t run well on commodity hardware because they’re simply too big. A good rule of thumb is to choose a model that fits into existing VRAM, along with the memory needed for a sizable token context (the more, the better). Also, the model should be suited to coding and development work. Some models in this vein that fit comfortably into 8GB VRAM include:

Setting up BYOK mode in VS Code

Once you have a model up and running, you can integrate it with Visual Studio Code. If you’ve disabled VS Code’s AI features, you will need to turn them on. Make sure the setting chat.disableAIFeatures is turned off. You can find it in Settings | Chat | Miscellaneous.

Third-party language models are managed through Visual Studio Code’s language model list. Press Ctrl-Shift-P and type Manage Language Models to open the list of existing language models.

Managing VS Code's AI language model list

Managing VS Code’s AI language model list. The models available by default are only models available as external APIs, not models that run locally.

Foundry

First you will see a list of the built-in models, which are all externally hosted. To add a new model, select Add Models at the top right and select Custom Endpoint.

You’ll then get a series of prompts:

  • Group Name: This is “Custom Endpoint” by default, but you can choose any name you want. The name is strictly for organizing the model list and doesn’t affect things like model recognition or connectivity.
  • API Key: If you’ve configured LM Studio to use an API key for serving models, provide it here. If you’re hosting the model locally and you haven’t explicitly set up API keys, you can leave this blank.
  • API Type: The options here are Chat Completions, Responses, and Messages. Most of the time you’ll want to use Responses, as it’s the most general-purpose option of the three.

Once you finish providing those answers, you’ll be dropped into a modal editor for a JSON file that holds the details about the endpoint you’re configuring.

A newly created custom endpoint for a locally hosted model

A newly created custom endpoint for a locally hosted model. The ID, name, and URL still need to be defined for this model to be useful.

Foundry

You’ll need to provide a few more details by typing them into the labeled fields:

  • id: A text field that uniquely identifies this particular entry. The choice of ID is pretty much arbitrary; if you’re using only a single model, the ID could be the model name.
  • name: The name of the model that is used to identify it on the model server. In LM Studio, you can get this name by clicking on My Models in the main interface, then selecting the three-dot icon for the model in question and clicking Copy Default Identifier. For Qwen 2.5, for instance, name might be something like qwen2.5-coder-7b-instruct.
  • url: The URL to the server’s endpoint. On LM Studio, this defaults to something like http://127.0.0.1:1234/v1. The /v1 at the end is important because that endpoint is used for autodiscovery of models and their capabilities.

The other fields generally don’t need editing. Most models have tool calling functionality. If you know for a fact that the model you’re using doesn’t have vision support, then set vision to false.

Once you have these fields filled in, you can close the modal editor to save the changes. If you reload the Manage Language Models page, you’ll now see your new endpoint:

A newly created local endpoint

A newly created local endpoint. The choice of name and group is arbitrary. “Custom Endpoint” is the default name for a newly created group of endpoints.

Foundry

You should now be able to launch the chat window and use the defined model for conversation and utilities:

Conversing with the local model using VS Code's chat window

Conversing with the local model using VS Code’s chat window. Note the selected code block in the left pane that is being used as the context for the conversation.

Foundry

One current, and major, limitation of Visual Studio Code’s BYOK functionality is that it only works for chat and utility tasks. It doesn’t allow you to use a local model for inline suggestions or code completions. The only way to take advantage of local models for expanded functionality with VS Code is to use a third-party tool like Continue.

It isn’t clear if Microsoft will eventually lift this restriction. GitHub Copilot integration in VS Code is a large part of how Copilot as a service reaches its target audience. For the time being, you can certainly use third-party and local models for a significant part of your AI-assisted development work in VS Code, and you can close the functionality gap with additional tooling.

High-Throughput Methods Decode Biomarkers and Indoor Exposure

21 June 2026 at 06:11

In an era where environmental pollutants increasingly threaten public health, breakthrough scientific methodologies are emerging to decipher the complex puzzle of chemical exposures in everyday life. The U.S. Environmental Protection Agency (EPA), through its innovative Exposure Forecasting (ExpoCast) project, has unveiled a suite of high-throughput novel approaches that promise to revolutionize our understanding of human exposure to hazardous substances. These new approach methodologies integrate cutting-edge computational power, biomonitoring data, and machine learning to clarify how chemicals enter and navigate the human body via different exposure pathways.

At the core of this scientific leap is the urgent need to move beyond traditional, labor-intensive measures of exposure assessment. Conventional methods, reliant on direct environmental sampling or biomarker tracking alone, often provide fragmented or delayed insights. ExpoCast’s high-throughput frameworks address this by enabling the rapid processing of vast chemical datasets and synthesizing multifaceted exposure routes—dermal contact, inhalation, and ingestion—into cohesive predictive models. This integration forms the backbone of a new era in toxicological science, one that could empower preventive public health strategies with unprecedented accuracy and speed.

The advanced computational techniques deployed in this research pivot on two pivotal innovations. First, the ability to infer chemical intake directly from metabolite measurements represents a quantum leap in exposure science. Metabolites—the biochemical footprints left by toxicants within the body—offer a window into the internal chemical burden of an individual. This invertible analytic approach not only isolates the true extent of chemical accumulation but also contextualizes it within the dynamic processes of metabolism and excretion. Such resolution provides critical clues for both risk characterization and regulatory evaluation.

Complementing this metabolite-centric analysis are high-throughput models that simulate multi-pathway exposures. Unlike prior assessments that treated exposure routes in isolation, these models encapsulate the reality of simultaneous, overlapping chemical encounters encountered in everyday environments. By integrating data across air, dust, water, and dietary matrices, the models generate comprehensive exposure profiles that reflect the true cumulative burden experienced by populations. This holistic perspective marks a paradigm shift in exposure science, with far-reaching implications for epidemiological research and environmental policy.

Another cornerstone of the ExpoCast project’s success lies in its deployment of sophisticated machine learning (ML) algorithms to bridge pervasive data gaps. Chemical exposure data are notoriously incomplete, especially for emerging contaminants and complex mixtures. The machine learning methods exploit chemical structures and existing information repositories to predict missing values, refine exposure estimates, and identify likely high-exposure scenarios. Through these predictive analytics, the EPA’s approach dramatically enhances the resolution and reliability of exposure assessments without the untenable demands of large-scale physical sampling.

The strength of coupling high-throughput analytics with ML-based data gap filling is evident in a recently published case study application that specifically targets indoor environments. Indoor settings are recognized as critical exposure venues given the amount of time individuals spend inside homes, workplaces, and public buildings. In this case study, researchers synchronized biomarker findings from human subjects with media-specific chemical concentration measurements—dust, indoor air, and surface residues—to validate the accuracy and applicability of their models. The congruence observed underscores the potential of these next-generation methodologies to accurately capture exposure nuances in real-world scenarios.

Delving into the technicalities, the approach of inferring chemical intake from biomarker data involves mechanistic, pharmacokinetic models. These models simulate the absorption, distribution, metabolism, and elimination (ADME) of chemicals, allowing reverse calculation from measured metabolite concentrations back to estimated exposure doses. Integrating population variability and uncertainty quantification within these models further refines predictions, supporting more nuanced risk assessments that reflect real human diversity and exposure complexities.

High-throughput exposure models, meanwhile, employ automated workflows powered by large chemical libraries, exposure factor databases, and physiological parameters. These workflows rapidly generate exposure estimates across thousands of chemicals and scenarios, facilitating prioritization in regulatory contexts. The incorporation of multi-pathway assessments elevates these models beyond simple single-route frameworks, capturing interactive effects such as dermal absorption following inhaled volatilization, or ingestion arising from hand-to-mouth transfer of settled dust.

Machine learning strategies, spanning supervised and unsupervised techniques, utilize features derived from chemical structure descriptors, physicochemical properties, and known exposure pathways to fill data voids. These models can predict exposure likelihood, magnitude, and temporal patterns with quantifiable confidence. Importantly, the EPA team employed interpretability-focused ML algorithms to ensure that the models’ decision-making processes remain transparent to toxicologists and risk assessors, a critical factor for regulatory acceptance and scientific scrutiny.

Together, these novel methodologies embody a systems-level approach to understanding chemical exposures that integrates biological, environmental, and computational sciences. They represent a shift from descriptive monitoring to predictive and mechanistically informed exposure science, capable of anticipating emerging public health threats before widespread harm occurs. Such anticipatory capacity aligns with modern needs for proactive environmental health management amid ever-expanding chemical use.

The implications extend beyond academia or regulatory agencies. Public health practitioners, clinicians, and community advocates can leverage these insights to better understand exposure disparities, tailor interventions, and inform vulnerable populations. For instance, accurately predicting exposure levels in indoor environments helps prioritize remediation or behavior modification strategies for those disproportionately impacted by chemical pollutants, such as children or individuals in lower socioeconomic strata.

From an innovation standpoint, the ExpoCast project exemplifies the power of integrating novel in silico tools with empirical biomonitoring, fostering a virtuous cycle of model refinement and real-world validation. This iterative process ensures that computational predictions remain grounded in biological realities, enhancing confidence in exposure and risk evaluations. Furthermore, as chemical inventories expand and new compounds emerge, these scalable, automated methodologies will be indispensable for keeping pace with the evolving regulatory landscape.

The broader environmental science community stands to benefit from adopting similar high-throughput, machine-learning-enabled approaches. The generalizability of these methodologies means they can be adapted for global chemical monitoring programs, occupational health assessments, and ecosystem exposure analyses. Cross-disciplinary collaboration will be critical to extend these tools and harmonize data frameworks, advancing a unified, internationally coordinated approach to chemical safety.

In conclusion, the EPA’s ExpoCast-driven advancements represent a milestone in exposure science, knitting together innovative analytical methods to unravel the complexities of human-chemical interactions. By harnessing metabolite-informed intake reconstruction, multi-pathway exposure modeling, and machine learning-based data gap filling, the project paves the way for more accurate, timely, and insightful exposure assessments. This transformative toolkit holds promise to enhance chemical risk management, protect public health, and guide sustainable environmental stewardship in an increasingly chemical-dependent world.

The research outlined in the recent publication epitomizes the potential of high-throughput new approach methodologies to revolutionize exposure science across diverse settings—from homes and workplaces to broader communities. Continued development, validation, and deployment of such integrative frameworks will be paramount in confronting the escalating challenges posed by chemical exposures in the 21st century.


Subject of Research:
Development and application of high-throughput new approach methodologies for complex chemical exposure assessment, involving biomarker inference, multi-pathway exposure modeling, and machine learning-driven data gap filling.

Article Title:
Case study application of high-throughput new approach methodologies for exposure to the interpretation of matched biomarker and indoor media measurements.

Article References:
Jacketti, M.A., Biryol, D., Setzer, R.W. et al. Case study application of high-throughput new approach methodologies for exposure to the interpretation of matched biomarker and indoor media measurements. J Expo Sci Environ Epidemiol (2026). https://doi.org/10.1038/s41370-026-00926-y

Image Credits: AI Generated

DOI: 21 June 2026

PGS Browser: Personalized Polygenic Score Analysis Platform

21 June 2026 at 01:25

In the ever-evolving field of genomics, a significant leap has been achieved with the introduction of the PGS Browser, a novel public platform designed to transform the way researchers, clinicians, and individuals interact with polygenic scores. Polygenic scores (PGS) are quantitative measures that capture the cumulative effect of numerous genetic variants across the genome, predicting an individual’s predisposition to complex traits and diseases. This new platform promises not just accessibility but also interpretative power, enabling a personalized approach to genomic data that could reshape personalized medicine and risk assessment paradigms worldwide.

At the heart of this transformative tool lies a sophisticated integration of vast genomic datasets, advanced computational algorithms, and user-friendly interfaces. The PGS Browser aggregates polygenic scores derived from an array of large-scale genome-wide association studies (GWAS), providing an unprecedented resource where users can explore the genetic architecture of diverse traits. One of the platform’s most compelling features is its capacity to personalize polygenic risk predictions by incorporating individual genetic data with contextual healthcare analytics, bridging the longstanding gap between raw genetic information and actionable clinical insights.

Traditionally, polygenic scores have been calculated using fixed sets of genetic variants, often constrained by limited population samples or specific ancestral backgrounds. This poses significant challenges regarding the portability and generalizability of these scores across diverse populations. The PGS Browser addresses this limitation head-on by incorporating multi-ancestry datasets and advanced statistical models that recalibrate polygenic scores for diverse genetic ancestries. This opens new horizons in achieving equity in genomic medicine, ensuring individuals from underrepresented populations have access to precise, contextually relevant risk evaluations.

The technical backbone of the PGS Browser involves complex methodologies that include linkage disequilibrium (LD) adjustment, penalized regression frameworks, and machine learning techniques, all optimized for high-throughput and scalable analysis. These computational advances optimize the balance between predictive accuracy and overfitting, a persistent challenge in polygenic score modeling. By dynamically adjusting for confounding genomic features and population stratification, the platform produces risk scores that are both statistically robust and biologically interpretable.

One of the critical innovations within the platform is its interpretability module, designed to unpack the black-box nature of polygenic predictions. Users are not only presented with their personalized polygenic scores but also receive detailed visualizations and annotations explaining the contribution of key genetic loci, biological pathways involved, and potential gene-environment interactions. This level of detail empowers clinicians to make informed decisions and patients to understand the genetic basis of their risks, paving the way for targeted preventative strategies and lifestyle modifications.

From a healthcare perspective, the implications of the PGS Browser extend far beyond academic research. The platform is a strategic tool for genetic counseling, allowing healthcare providers to identify individuals at elevated risk for complex diseases such as cardiovascular disease, diabetes, and certain cancers before clinical symptoms manifest. Early identification through polygenic risk enables preemptive interventions, personalized monitoring, and tailored therapeutic approaches, underscoring a shift from reactive to proactive medicine.

Moreover, the PGS Browser operates with a commitment to transparency and reproducibility, addressing critical concerns in genetic epidemiology. All computational workflows are openly accessible, enabling peer verification and fostering collaborative improvement. The platform also integrates with existing biobank data through standardized protocols, facilitating validation studies and meta-analyses that enhance the reliability of polygenic scores across global cohorts.

A particularly noteworthy aspect of the platform is its potential role in pharmacogenomics. By correlating polygenic scores with drug response phenotypes, the browser could assist in identifying individuals who might benefit from specific medications or require dosage adjustments. This integration with personalized medicine elevates the clinical utility of polygenic scores from risk stratification to therapeutic optimization, highlighting the multi-dimensional impact of genomic data in patient care.

The PGS Browser also bridges the gap between research and public engagement. Designed with intuitive navigation and educational resources, it invites an increasingly genomically literate public to explore their genetic predispositions within a responsible and secure framework. This democratization of genetic information fosters greater awareness and empowerment while maintaining stringent privacy standards, an essential consideration in the era of big data.

In operational terms, the platform boasts scalability features capable of handling millions of individuals’ data concurrently, a necessity given the rapid expansion of genomic databases worldwide. The utilization of cloud-based infrastructures, coupled with containerized computational environments, ensures flexible deployment across various institutional settings while preserving data security and compliance with regulatory frameworks such as GDPR.

From a scientific perspective, the availability of such a public platform catalyzes the discovery of novel gene-trait associations by allowing researchers to perform systematic, large-scale analyses that correlate polygenic scores with phenotypic data. This accelerates the identification of biological mechanisms underlying complex traits, informing subsequent functional studies and therapeutic development pipelines.

Ethical considerations permeate the development and deployment of the PGS Browser. The platform incorporates informed consent modules, guidelines on interpretation limitations, and warnings against deterministic views of genetic risk. By fostering responsible use and interpretation, the platform promotes ethical standards within a field where genetic data can easily be misunderstood or misapplied.

Furthermore, the PGS Browser represents a leap forward in standardizing polygenic score methodologies. Historically, disparate scoring algorithms and variable reporting conventions have hindered comparability across studies. This unified platform offers a harmonized framework that promotes methodological consistency, enabling the scientific community to consolidate findings and build upon a shared foundation.

The cross-disciplinary collaboration manifested in the creation of the PGS Browser highlights the convergence of genetics, bioinformatics, data science, and clinical medicine. This integrative approach is crucial to addressing the complexities of polygenic risk and translating genomic insights into tangible health benefits, marking a pivotal moment in the genomics era.

Looking forward, the PGS Browser sets the stage for continuous evolution. Planned enhancements include integration with longitudinal health records, expansion of trait coverage particularly in psychiatric and neurological domains, and real-time updating as new GWAS data emerge. Such adaptability ensures the platform remains at the forefront of personalized genomics research and application.

In conclusion, the PGS Browser embodies a landmark achievement in the democratization and personalization of polygenic score analysis. By merging rigorous computational techniques with accessible design and ethical mindfulness, it empowers a broad spectrum of users to harness the predictive power of genomic data. This innovation holds transformative potential for healthcare, research, and public understanding, catalyzing a new era in precision medicine where genetic insights are personalized, interpretable, and actionable like never before.


Subject of Research: Development and deployment of a public platform for personalized polygenic score analysis and interpretation.

Article Title: PGS Browser: A Public Platform for Personalized Polygenic Score Analysis and Interpretation.

Article References:
Kolosov, N., Reeve, M.P., Briotta Parolo, P.D. et al. PGS Browser: a public platform for personalized polygenic score analysis and interpretation. Nat Commun (2026). https://doi.org/10.1038/s41467-026-74461-7

Image Credits: AI Generated

Seismocardiography Estimates Cardiorespiratory Fitness in Elderly

20 June 2026 at 15:29

In a groundbreaking advancement for geriatric health assessment, researchers have unveiled a novel nonexercise approach to estimate cardiorespiratory fitness in older adults by utilizing seismocardiography (SCG). This innovative technology harnesses the subtle vibrations produced by cardiac activity, enabling precise monitoring of cardiovascular function without the need for physical exertion. As aging populations increase globally, the demand for accessible and reliable methods to evaluate heart and lung fitness has never been higher, making this development not only timely but also revolutionary.

Cardiorespiratory fitness traditionally requires exercise testing, involving treadmill or bicycle protocols that may pose risks or be impractical for elderly individuals with limited mobility or chronic conditions. The novel system employing SCG bypasses these challenges, offering a safe and feasible alternative that significantly minimizes patient burden. SCG captures micro-vibrations generated by the heart during each beat using sensitive accelerometers placed on the chest, translating mechanical cardiac events into quantitative data reflective of cardiovascular performance.

The study, led by Sundberg, Gates, and Boraxbekk among others, meticulously validated the use of SCG signals against established measures of cardiorespiratory fitness, such as VO2 max testing, across a diverse cohort of older adults. Their results demonstrated remarkable correlation, confirming that SCG can serve as a reliable proxy for exercise-based evaluations. This breakthrough is poised to transform clinical practice by facilitating widespread cardiovascular screening and monitoring in geriatric populations without exposing them to physical strain.

One of the pivotal technological advances underpinning this approach is the enhancement of signal processing algorithms that can accurately decipher the complex mechanical patterns of heart activity from SCG data. These algorithms filter noise and artifacts, isolating key features such as timing intervals between cardiac events that are indicative of cardiac output and fitness levels. By employing machine learning techniques, the research team optimized predictive models that link SCG metrics with cardiorespiratory capacity.

Beyond the impressive technical accomplishments, the application of SCG for fitness estimation aligns perfectly with the principles of personalized medicine. By providing continuous, noninvasive monitoring methods, clinicians can tailor interventions and lifestyle recommendations based on real-time fitness metrics, facilitating proactive management of cardiovascular health. This could substantially reduce the incidence of cardiovascular events, improve quality of life, and enhance longevity in aging adults.

Importantly, this methodology opens new avenues for remote health monitoring. The compact sensors utilized for SCG are lightweight, unobtrusive, and capable of wireless transmission, enabling integration with mobile health platforms. This may empower elderly individuals to measure their cardiorespiratory fitness regularly from the comfort of their homes. Such democratization of health data can lead to earlier detection of functional decline, prompt clinical interventions, and reduced healthcare costs.

From a physiological perspective, seismocardiography reveals intricate interactions governing heart mechanics, including myocardial contractility and valve function, which are directly tied to oxygen delivery and utilization — the cornerstone of cardiorespiratory fitness. This depth of insight surpasses conventional pulse or blood pressure monitoring, offering a richer dataset for comprehensive cardiovascular assessment. The capacity to obtain these insights passively without exercise expends minimal energy, crucial for frail patients.

The research also emphasizes the feasibility of SCG in monitoring dynamic changes in fitness over time. Whereas exercise-based testing reflects a snapshot requiring considerable effort and clinical resources, SCG’s accessibility permits serial measurements that track progression or regression in cardiorespiratory health. This longitudinal view enhances clinicians’ ability to evaluate treatment efficacy and adjust care plans appropriately.

Moreover, SCG technology exemplifies the convergence of biomechanics, biomedical engineering, and data science, epitomizing modern healthcare innovation. The fusion of robust sensors with advanced computational methods has produced a tool that transcends standard diagnostic modalities, offering a more comprehensive and patient-friendly option. This interdisciplinary synergy highlights the potential for future wearable technologies to expand their role in chronic disease management.

Addressing limitations, the study carefully acknowledges challenges such as variability in SCG signal quality due to anatomical differences and external factors. However, by employing adaptive algorithms and calibration protocols, the researchers have mitigated many of these issues, ensuring consistent performance across diverse patient profiles. Ongoing refinements aim to further enhance accuracy and user-friendliness, making broad clinical adoption realistic.

The implications of this research extend beyond geriatric cardiology, potentially influencing rehabilitation programs, sports science, and preventive medicine. With further validation, SCG could monitor athletes’ fitness without exhaustive testing or assist in evaluating pulmonary function in respiratory diseases. Its versatility underscores the broad applicability of biomechanical sensing in health monitoring paradigms.

In conclusion, the integration of seismocardiography for the nonexercise estimation of cardiorespiratory fitness in older adults marks a paradigm shift in cardiovascular health assessment. By circumventing the constraints of traditional exercise testing, this technology enables safe, efficient, and insightful evaluations that can be performed repeatedly and remotely. As the elderly demographic surges worldwide, the deployment of such innovative methods will be pivotal in optimizing healthcare delivery and promoting healthier aging.

The promise of SCG transcends mere technological novelty; it represents a compassionate approach to health evaluation that respects the physical limitations and safety of vulnerable populations. Empowering healthcare providers with precise, noninvasive tools enriches clinical decision-making and enhances patient outcomes. Looking ahead, continued research and integration with digital health ecosystems will likely establish seismocardiography as a cornerstone in the management of cardiovascular fitness.

Ultimately, the study spearheaded by Sundberg and colleagues not only broadens scientific understanding but also provides a tangible blueprint for implementing cutting-edge sensing technologies in everyday clinical practice. The synergy of engineering excellence, clinical insight, and patient-centric design encapsulates the future of medical innovation — one that prioritizes accessibility, safety, and actionable intelligence for all.


Subject of Research: Nonexercise estimation of cardiorespiratory fitness in older adults using seismocardiography.

Article Title: Seismocardiography for nonexercise estimation of cardiorespiratory fitness in older adults.

Article References:
Sundberg, M., Gates, A.T., Boraxbekk, C.J., et al. Seismocardiography for nonexercise estimation of cardiorespiratory fitness in older adults. BMC Geriatr (2026). https://doi.org/10.1186/s12877-026-07771-6

Image Credits: AI Generated

Tired of Gemini in Google Docs? Here’s How to Turn It Off

19 June 2026 at 23:25
Learn how to turn off Gemini’s bottom bar in Google Docs and adjust Workspace smart feature settings if you want fewer AI prompts while writing.

Researchers grow a hypothesis tree for AI coding agents

19 June 2026 at 23:16

AI coding agents can tend to isolate research, running experiments and generating ideas that are then forgotten when context windows reset. This can waste tokens, as models then repeat the same mistakes and hit the same dead ends.

But new research argues that it’s not the model itself, but the overarching ‘tree,’ that needs tweaking. To that end, data scientists from the Gaoling School of Artificial Intelligence, Renmin University of China, and Microsoft Research have introduced Arbor, a “persistent hypothesis tree” that helps agents remember and refine learnings over long research sessions.

A long-lived coordinator manages research strategy across the tree, while short-lived executors spin up isolated worktrees to test different hypotheses. As results come back, the tree updates, narrowing and refining throughout experimentation.

In practical tests, this technique delivered more than two-fold performance gains over standard AI coding agents across real-world engineering tasks, for the same budget.

This is because, said Mahmoud Ramin, a research director at Info-Tech Research Group, “Arbor accumulates information over time and allows agents to build upon prior discoveries just as humans do, through learning, adaptation, and eventually building upon what they have learned in the past.”

How Arbor grows

Arbor’s builders argued that longer execution on its own does not guarantee research progress. The challenge is maintaining a state that turns many individual attempts into “cumulative hypothesis refinement.”

Further, progress should not depend on human overseers regularly stepping in to dictate logical next steps or interpret the meaning of previous trials, they noted. To be truly autonomous, agentic research frameworks must maintain connections between experiments, data, results, and failures over time.

Arbor is built to fulfill three system requirements. First, it must be able to branch as sub-trees test out competing hypotheses that are all potentially plausible. At the same time, unrestricted branching can degenerate the whole framework, so that must be controlled to remain organized. The researchers call this “branching with coherence.”

Second, the infrastructure must separate local execution from overarching strategy. Testing out single hypotheses requires short-horizon tasks like editing, debugging, and evaluation. But these should not “obscure” the larger tree making decisions based on evidence gathered across the whole run.

Finally, the systems must be able to distinguish exploratory improvement from verified improvement. This prevents AI from overfitting during trial-and-error instead of iteratively learning from underlying patterns.

Persistence is at the core; the tree links hypotheses and ideas, the code or configuration artifacts used to test them, experimental evidence (results, metrics), and distilled insights (such as “this data filter helped, but this learning rate scheduler didn’t”).

Once a project kicks off, shorter-execution work trees run code, log their work, and collect metrics. The long-lived coordinator above them serves as the de-facto head of research, keeping an eye on the process, updating nodes, selecting “promising leaves,” pruning or merging branches, propagating reusable lessons, and deciding which hypotheses to pursue next.

“The tree therefore acts as the operational research state of the system,” Arbor’s builders wrote. “It is simultaneously the search frontier, the memory of past attempts, and the audit trail for verified artifact improvement.”

Outperforming Codex and Claude on new data

To test how well this process works, the researchers evaluated Arbor in an autonomous optimization (AO) setting: the agent was given an initial research artifact (a data pipeline, harness, or training script) and was tasked with improving its “held-out performance” through iterative experimentation, without human steering. Held-out performance is a machine learning (ML) metric that evaluates how well models are able to generalize on data they haven’t seen before.

The tree-based architecture was tested on several real research tasks across model training (its ability to improve training recipes and hyperparameters), harness engineering (how well it can upgrade evaluation or training harnesses), and data synthesis (its capacity to generate better data for training or evals).

Ultimately, Arbor outperformed the average held-out gains of Codex and Claude Code by 2.5x, for the same resource budget.

The takeaway, said the researchers: Keeping a structured, evolving hypothesis tree yields greater performance improvements than running the same models as ‘memoryless’ coding agents.

Arbor’s most innovative feature is its ability to maintain the agent’s memory and retain relevant data from prior attempts and hypotheses, Info-Tech’s Ramin pointed out, and, he said, “the next step for autonomous agents may be accumulating evidence over time.”

However, this does raise concerns about the auditability of robust research environments at a large scale, he noted. “As autonomous agents become more capable of performing work without human operators overseeing them, enterprises will need transparency into how and/or why an agent took a specific action or reached a certain conclusion.”

Why AI coding debt is different

18 June 2026 at 10:00

In hardware, when you ship something broken, the consequences are severe and often irreversible. That’s the world I worked in for years, in verification roles at Mellanox and later at Alibaba. The stakes forced the industry to build a rigorous verification culture. You proved designs worked before they left the building.

In software, verification disciplines look like CI/CD pipelines, static analysis, canary deployments, and observability. But those systems were built around code written at human speed, with human comprehension baked into the process. AI code generation has broken that assumption. The writing process can no longer be trusted to carry institutional knowledge and judgment into the codebase. The industry is being pushed toward the kind of rigorous verification culture that hardware engineers have practiced for decades.

Enterprises are generating code faster than at any point in history. Google recently disclosed that 75% of the company’s new code is now AI-generated. Meta has set internal targets requiring most of its engineers to generate the majority of their committed code with AI tools by mid-2026. The velocity gains are significant. But a growing body of evidence suggests the industry is accumulating a new form of technical debt, one that is less visible than the traditional kind and harder to unwind. It’s also preventable, and the organizations that get ahead of it will have a meaningful advantage over those that don’t.

Understand what makes this debt different

The standard narrative frames this as AI writing bad code. That’s not quite right. The more precise problem is cognitive debt: the loss of understanding of how and why software was built the way it was.

When a human writes code, something else happens alongside the typing. They simulate edge cases, reason through dependencies, and make judgment calls grounded in organizational context, including the business requirements behind a feature, the best practices the team has established, and the reasoning behind past architectural choices. That cognitive loop is how institutional knowledge gets built. When AI writes the code, you can get output that is syntactically correct, passes CI, ships cleanly, and leaves no one holding the mental model. The code works until something changes or breaks, and then the team is excavating a black box.

This is distinct from traditional technical debt, which is messy code. Cognitive debt is invisible code that functions but that nobody truly owns. And it compounds faster, because the same velocity that makes AI generation attractive is what prevents anyone from stopping to build the understanding that maintainability requires.

GitClear’s analysis of 211 million changed lines of code across major repositories found that during 2024, duplicate code blocks of five or more lines increased eightfold, while refactoring dropped from 25% to under 10% of all code changes. Refactoring is the slow, unglamorous work that keeps codebases healthy, and developers are doing far less of it. Google’s 2024 DORA report found that a 25% increase in AI adoption correlates with a 7.2% decrease in delivery stability. DORA analysts note that the root cause isn’t flawed code per se; AI inflates batch sizes, and larger changesets have always been riskier to ship.

These findings aren’t indictments of AI-assisted development. They’re diagnostics, and they point toward a specific set of fixes.

Close the context gap first

In a survey of 609 developers we conducted last year, 65% said AI misses relevant context during critical tasks like refactoring, writing tests, or reviewing code. Context is the primary driver of AI code quality, and it’s where most enterprise organizations are underinvesting.

When an AI tool generates code without access to your organization’s architectural decisions, historical pull requests, security policies, or existing module patterns, you get solutions that are locally correct but globally incoherent. Closing that gap requires context engineering: ensuring the tools and agents you use have access, at the right moment, to the right organizational knowledge, and the judgment to determine what is actually relevant for a given task. A retrieval system that surfaces too much irrelevant context can degrade output quality as readily as one that surfaces too little. The specific tooling matters less than the discipline. Context infrastructure needs to be actively maintained, not indexed once and forgotten.

Build this infrastructure before you scale AI generation. Retrofitting is significantly harder. Treat it the way you treat your CI pipeline, as a prerequisite for safe production deployment.

Consider what happens when a team has built this context infrastructure well. Their code review tooling knows about a deprecated internal API, because that deprecation decision lives in months of past pull request discussions that have been indexed and surfaced. When generated code references the old API, the review flags it. Without that context layer, the same mistake gets waved through every time. That’s the kind of institutional knowledge that evaporates when humans stop writing every line of code, and that you have to actively work to preserve.

Build a verification layer that matches your generation velocity

Almost all of the investment in AI-assisted development has gone into generation. Very little has gone into verification. That imbalance is where the tech debt accumulates.

I think of these as the blue team and the red team. The blue team covers code generation, autocomplete, and agentic coding. It’s getting the headlines, the budgets, and the product launches. The red team covers integrity checks, behavior coverage, and alignment with organizational standards. In most organizations, it’s an afterthought. A CI pipeline catches obvious failures. A code review might happen, but reviewers are overwhelmed by the volume of AI-generated output and cannot meaningfully evaluate all of it. The result is code with a veneer of having been reviewed without anyone having actually understood it.

The Crowdstrike outage of 2024 is worth keeping in mind here. AI didn’t generate the problematic code, but the incident illustrated what happens when a single software error propagates through production systems without sufficient verification. That exposure multiplies when code is being generated faster than humans can understand it.

A real verification layer means automated analysis that evaluates whether generated code aligns with your organization’s best practices, architectural standards, and compliance requirements. It means test coverage that reflects intended behavior, not only the happy path the AI chose to generate tests for. And it means traceability: a connection between the requirement and the implementation, so that six months from now, someone can understand what the code does and why it exists.

The numbers support investment here. In the same developer survey, teams that integrated AI into their code review workflow saw quality improvements in 81% of cases, compared to 55% for comparable teams without it. 

Make ownership non-negotiable

Every piece of AI-generated code in production needs an accountable human who understands it well enough to maintain it. This is harder than it sounds, and it’s where most organizations are falling short.

The same velocity that makes AI generation attractive also creates pressure to skip the slow work of genuine comprehension. A developer reviews a 500-line pull request that an AI generated in three minutes and faces a real choice: spend two hours actually understanding it, or approve it because it looks right, passes the test, and “LGTM” (looks good to me). 

Real ownership means slowing down generation velocity enough to allow for meaningful review, and being explicit with your team that this is the right trade-off. When that doesn’t happen, you’ve started building your next legacy system.

What to do this quarter

The good news is that none of this requires a multi-year transformation. The structural problems are real, but they have concrete solutions, and engineering leaders can make meaningful progress on all three fronts without waiting for the next budget cycle.

  • Audit your context infrastructure. If your AI tools are generating code without access to your organization’s architectural decisions, deprecated APIs, and security policies, fix that before expanding generation velocity further. The quality of context determines the quality of output.
  • Invest in the red team. Establish an automated code quality and governance layer that evaluates generated code against your specific organizational standards, beyond functional correctness. This is a distinct investment from your code generation tooling and needs to be treated as such.
  • Establish ownership explicitly. Every AI-generated feature in production should have a human owner who genuinely understands it. Make that a formal requirement.

The organizations that get this right will find that AI generation becomes far more reliable once it has a verification layer underneath it. The ones that don’t will keep shipping faster while understanding their systems less, until the accumulated debt forces a reckoning. That’s a solvable problem. The question is whether you solve it now or later.

—

New Tech Forum provides a venue for technology leaders—including vendors and other outside contributors—to explore and discuss emerging enterprise technology in unprecedented depth and breadth. The selection is subjective, based on our pick of the technologies we believe to be important and of greatest interest to InfoWorld readers. InfoWorld does not accept marketing collateral for publication and reserves the right to edit all contributed content. Send all inquiries to doug_dineley@foundryco.com.

iSCORE-PD: Stem Cells Advance Parkinson’s Research

17 June 2026 at 23:57

In an unprecedented advancement for neurodegenerative disease research, a team led by Busquets, Li, Syed, and colleagues has unveiled iSCORE-PD, an innovative isogenic stem cell repository designed explicitly to accelerate Parkinson’s disease studies. Published in Nature Communications in 2026, this comprehensive collection represents a pivotal leap toward resolving the complex pathophysiology of Parkinson’s, a condition affecting millions worldwide yet still eluding curative therapies. The iSCORE-PD platform promises to redefine experimental paradigms by providing scientists with genetically matched cellular models that mirror the intricate genetic underpinnings of Parkinson’s disease.

Parkinson’s disease is characterized primarily by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta, leading to debilitating motor symptoms such as tremors, rigidity, and bradykinesia, alongside a spectrum of non-motor complications. Despite extensive research, there remains a conspicuous gap between clinical observations and mechanistic understanding at the cellular and molecular levels. Existing animal models and conventional stem cell lines often fall short in recapitulating the exact human pathology. The iSCORE-PD initiative addresses this deficiency head-on by harnessing isogenic stem cell lines, which are genetically identical except for defined Parkinson’s-relevant mutations, thus enabling unprecedented control over genetic variables.

The technical foundation of iSCORE-PD relies on advanced genome editing methodologies, most notably CRISPR/Cas9 technology. By precisely introducing or correcting mutations in key genes implicated in Parkinson’s pathogenesis such as SNCA, LRRK2, PINK1, and PARKIN, researchers have generated isogenic pairs of induced pluripotent stem cells (iPSCs). These iPSC lines can subsequently be differentiated into dopaminergic neurons or other relevant cell types, facilitating side-by-side comparisons that isolate the effects of specific genetic alterations without the confounding noise of inter-individual genetic variability.

One of the remarkable features of the iSCORE-PD collection is its extensive genomic validation pipeline. Whole genome sequencing and transcriptomic analyses are systematically employed to ensure the integrity and authenticity of the edited lines, confirming that off-target effects are minimized and that the genetic landscape conforms precisely to intended edits. This meticulous validation is crucial for downstream experiments intending to dissect subtle cellular phenotypes attributable to Parkinson’s mutations with a high degree of confidence.

The availability of these isogenic cell lines dramatically enhances the fidelity of disease modeling. Scientists can now observe, in real time and within a human cellular context, the cascade of pathological events triggered by individual mutations. For instance, iSCORE-PD lines harboring the G2019S mutation in LRRK2 have already demonstrated distinct lysosomal dysfunction and mitochondrial impairment, hallmarks of Parkinson’s-related neurodegeneration. These insights provide vital clues about the molecular mechanisms that underpin neuronal vulnerability and death.

Beyond mechanistic studies, iSCORE-PD serves as an invaluable platform for drug discovery and therapeutic screening. High-throughput assays conducted on these standardized cellular models allow for robust evaluation of candidate compounds’ efficacy and toxicity. The isogenic background ensures that drug responses can be directly attributed to genetic contributors and not extraneous genomic differences, thereby accelerating the identification of promising therapeutic leads with increased translational potential.

Moreover, the iSCORE-PD repository supports integrative omics approaches. By coupling proteomics, metabolomics, and epigenomic profiling with the genetically defined cell lines, researchers can generate comprehensive molecular atlases elucidating the multifaceted alterations engendered by Parkinson’s-associated mutations. Such data-rich resources augment our understanding of disease heterogeneity and may reveal novel biomarkers for early diagnosis and progression monitoring.

The initiative also pioneers robust methodologies for modeling non-cell autonomous effects in Parkinson’s pathology. By co-culturing isogenic dopaminergic neurons with glial cells or other brain cell types derived from similarly engineered iPSC lines, investigators can explore the cell–cell interactions and inflammatory pathways that contribute to disease propagation. These complex in vitro systems increasingly resemble the in vivo brain microenvironment, bridging translational gaps.

In addition to its scientific hinge, iSCORE-PD represents a significant step forward in reproducibility and collaborative science. By providing open-access to a rigorously characterized and genetically standardized stem cell collection, the project promotes harmonization of experimental models across laboratories worldwide. This standardization mitigates discrepancies often observed in Parkinson’s research due to genetic heterogeneity of patient-derived cells and disparate culture conditions.

Ethical considerations have been front and center in the development and dissemination of the iSCORE-PD lines. The team has implemented stringent protocols to ensure donor anonymity, informed consent, and compliance with international guidelines for stem cell research. This ethical diligence is fundamental to fostering public trust and enabling broad scientific utilization with responsibility.

The iSCORE-PD research consortium envisions future expansion of the collection to encompass additional mutations, gene variants, and epigenetic modifications implicated in Parkinson’s disease, thereby creating an ever-more comprehensive toolkit for the field. This evolving repository will facilitate the study of gene–environment interactions and provide models for the sporadic forms of Parkinson’s that constitute the majority of cases.

Importantly, the development of iSCORE-PD aligns synergistically with advances in single-cell sequencing and live-cell imaging technologies. These combined approaches empower real-time monitoring of neuronal dynamics, synaptic connectivity, and intracellular trafficking in disease-relevant contexts. Such capabilities promise to unravel the temporal progression of neuronal dysfunction in unprecedented detail.

The translational impact of iSCORE-PD extends beyond fundamental research, holding profound implications for personalized medicine. Patient-specific isogenic lines can be derived, enabling evaluation of individualized drug responses and prediction of disease progression trajectories. This precision medicine paradigm could revolutionize clinical management and therapeutic development for Parkinson’s patients.

Finally, iSCORE-PD serves as a testament to the power of interdisciplinary collaboration, integrating expertise in stem cell biology, genome editing, neuroscience, bioinformatics, and clinical neurology. This concerted effort exemplifies how cutting-edge technologies, when harnessed collectively, can illuminate complex diseases and hasten the arrival of effective treatments.

In sum, the iSCORE-PD isogenic stem cell collection stands as a groundbreaking resource that transforms the landscape of Parkinson’s disease research. By providing genetically precise, highly validated cellular models, it enables unparalleled mechanistic insights, drug discovery opportunities, and personalized medicine applications. As the Parkinson’s field grapples with its most urgent challenges, iSCORE-PD promises to be a beacon guiding innovative interventions and ultimately improving patient outcomes worldwide.


Subject of Research: Parkinson’s disease; isogenic stem cell models; neurodegeneration; genome editing; induced pluripotent stem cells.

Article Title: iSCORE-PD: an isogenic stem cell collection to research Parkinson’s disease.

Article References:

Busquets, O., Li, H., Syed, K.M. et al. iSCORE-PD: an isogenic stem cell collection to research Parkinson’s disease.
Nat Commun (2026). https://doi.org/10.1038/s41467-026-74355-8

Image Credits: AI Generated

Liquid Metal Microcoils Revolutionize Endoscopic Haptics

17 June 2026 at 21:24

In a remarkable leap forward for medical technology, a team of researchers led by Zou, X., Zhang, J., and Chan, C.P.Y. have unveiled a groundbreaking advancement in haptic feedback systems designed specifically for endoscopic teleoperation and remote palpation. Detailed in their recent publication in npj Flexible Electronics, this innovative approach employs dense elastomeric liquid metal microcoil-based interfaces to transform how surgeons and medical professionals interact with remote internal environments. The intersection of flexible electronics, smart materials, and precision control opens new vistas for minimally invasive procedures and telemedicine.

At the heart of this breakthrough lies the integration of liquid metal microcoils encapsulated within elastomeric substrates, forming a highly sensitive yet mechanically robust haptic interface. These microcoils are capable of generating precise electromagnetic fields which can be finely tuned to mimic various tactile sensations encountered during palpation of organic tissues. The elastomeric medium ensures that the device remains soft and compliant, paralleling the flexibility of biological tissues, a critical characteristic for interfacing with delicate anatomical structures during endoscopic maneuvers.

Traditionally, the lack of tactile feedback in endoscopic teleoperation has been a significant barrier limiting the surgeon’s ability to perform nuanced examinations and manipulations remotely. Without real-time haptic cues, operators must rely heavily on visual data, often constraining them to less precise interventions. The dense microcoil architecture introduced here circumvents this limitation, delivering graded force feedback that enhances situational awareness and operational dexterity. This certainly augurs well for improved patient outcomes and expanded applicability of robotic-assisted minimally invasive surgeries.

The engineering challenge of embedding electrically conductive liquid metals within stretchable matrices is particularly formidable due to factors such as metal leakage, durability under repeated mechanical deformation, and signal fidelity. By leveraging advanced microfabrication techniques, the research team has managed to arrange multiple liquid metal microcoils in closely packed networks, maintaining electrical continuity while allowing for substantial skin-like elasticity. The resulting elastomeric platform simultaneously exhibits excellent mechanical endurance and electromagnetic responsiveness, making it highly suitable for continuous use in clinical settings.

Further advancing the technology, the microcoils’ electromagnetic emissions can be dynamically modulated to emulate various textures and firmness levels characteristic of different tissue types. Thus, the interface can replicate sensations ranging from firm nodules to soft cystic formations, invaluable during diagnostic remote palpation. This capacity to differentiate subtle differences in tissue compliance could revolutionize tele-diagnostic methodologies and enable the virtual presence of expert clinicians regardless of their physical location.

Additionally, the researchers demonstrated that the compactness and biocompatibility of their design allow seamless integration with existing endoscopic instruments. Since these haptic interfaces are fabricated on flexible substrates that conform to complex geometries, retrofitting current devices for enhanced tactile perception becomes feasible without significant hardware overhaul. This compatibility introduces a pragmatic pathway for rapid clinical adoption and accelerates the translation from lab prototype to bedside tool.

Significantly, the device’s exceptional spatial resolution stems from the microcoil density that surpasses conventional haptic arrays by an order of magnitude. This density enables highly localized force feedback, empowering surgeons to discern minute anatomical features and manipulative pressures, akin to natural touch. Enhanced spatial acuity not only minimizes inadvertent tissue damage but also refines the precision of surgical gestures performed remotely, a vital enhancement for robotic endoscopy.

The durability tests conducted reveal that the elastomeric microcoil arrays withstand thousands of mechanical cycles without degradation in electrical or tactile function. This endurance is crucial for clinical reliability, as surgical procedures often extend over hours and necessitate consistent tactile feedback. The elastomer’s resistance to bodily fluids and sterilization processes further underscores its practicality for repeated use within sterile operating room environments.

Beyond endoscopy, the principles underpinning this technology have vast implications across medical robotics and wearable health devices. From remote rehabilitation to advanced prosthetics, densely packed liquid metal microcoil arrays embedded in soft elastomers could deliver highly intuitive haptic sensations that bridge the gap between man and machine. Their ability to accurately simulate touch and force presents a paradigm shift in direct human-machine interaction technologies.

Expanding the scope of teleoperation, this innovation paves the way for real-time remote palpation performed by specialists thousands of miles away. The combination of high-fidelity haptic feedback with tactile sensation mapping can enable remote diagnosis with unprecedented accuracy. This is particularly transformative for geographically isolated healthcare facilities, where access to expert practitioners is limited, enhancing healthcare equity on a global scale.

Further insights from the study highlight that the electromagnetic microcoils can operate efficiently with low power consumption, vital for portable and battery-operated surgical tools. Efficient energy usage not only extends operational time but reduces heat generation, an important factor in preserving tissue safety and user comfort. The smart material approach balances functionality with operational pragmatism, addressing key limitations in current haptic technologies.

From a materials science perspective, the marriage of liquid metal and elastomer illustrates a masterclass in multifunctional composite design. The liquid metal component, inherently conductive and deformable, harmonizes with the elastomer’s resilience to achieve electro-mechanical transduction without compromising softness. This synergy redefines the possibilities of flexible electronics by providing a multi-physics platform capable of sensing, actuating, and adapting simultaneously.

Another notable aspect lies in the scalability of the fabrication method. This enables mass production of the microcoil arrays with reproducible quality and design flexibility tailored to varied endoscopic devices. Scalability is essential for widespread clinical deployment and cost-effectiveness. By providing a reliable route for industrial manufacturing, the researchers have addressed one of the critical barriers to translating cutting-edge soft electronics into real-world medical accessories.

In conclusion, Zou et al.’s pioneering contribution in developing dense elastomeric liquid metal microcoil-based haptic interfaces represents a landmark achievement with far-reaching consequences for telemedicine and minimally invasive surgery. Their meticulous integration of fluid mechanics, materials engineering, and electromagnetic control offers a new standard for tactile interaction in remote medical procedures. This breakthrough invigorates the field of flexible electronics and sets a blueprint for next-generation human-machine interfaces enhancing surgical precision and patient care worldwide.

As the medical community faces the continuing challenge of providing expert care in increasingly complex and constrained environments, innovations such as these provide a beacon for safely extending human touch beyond physical boundaries. Dense elastomeric liquid metal microcoil haptics are poised to redefine surgical telepresence, promising a future where distance no longer limits the healing power of human touch.


Subject of Research: Dense elastomeric liquid metal microcoil-based haptic interfaces for improving tactile feedback in endoscopic teleoperation and remote palpation.

Article Title: Dense elastomeric liquid metal microcoil-based haptic interfaces for endoscopic teleoperation and remote palpation.

Article References:
Zou, X., Zhang, J., Chan, C.P.Y. et al. Dense elastomeric liquid metal microcoil-based haptic interfaces for endoscopic teleoperation and remote palpation. npj Flex Electron (2026). https://doi.org/10.1038/s41528-026-00608-7

Image Credits: AI Generated

New Standard Sets the Bar for AI Performance in Routine Patient Care

17 June 2026 at 21:10

In a groundbreaking advancement for artificial intelligence in healthcare, researchers at Mass General Brigham have unveiled BRIDGE, a comprehensive multilingual benchmark designed to critically assess how effectively large language models (LLMs) comprehend and interpret clinical patient-care text. Unlike existing AI evaluation metrics that rely primarily on structured and standardized medical exam questions, BRIDGE is engineered to engage with the multifaceted and complex language found in real-world clinical communications, including electronic health records (EHRs), case reports, and patient-doctor consultations, across nine different languages. This innovation represents a transformative step toward making AI tools more reliable and contextually aware in actual healthcare settings.

The existing paradigm in medical AI evaluation has predominantly centered on licensing exam questions composed in a controlled, formalized medical lexicon. These assessments, while rigorous, often fall short of reflecting the nuanced, variable, and sometimes ambiguous language used in actual clinical environments. The BRIDGE benchmark circumvents this limitation by employing authentic clinical texts, which capture the complexities and heterogeneity inherent to patient care dialogues, medical documentation, and clinical decision-making processes. This shift brings essential granularity and relevance to model performance metrics, providing clinicians and developers with more actionable insights.

The creators of BRIDGE demonstrated the stark contrast in performance between conventional exam-based evaluations and real-world clinical comprehension. For instance, the highest-performing LLM evaluated scored impressively on standard medical exams, achieving up to 92%. However, when subjected to BRIDGE’s rigorous clinical text test, the same model’s proficiency plummeted to only 44.8%. This significant disparity exposes considerable gaps in the AI’s ability to grasp the subtle clinical context, implicit meanings, and domain-specific language patterns prevalent in healthcare communications.

To validate the robustness and breadth of BRIDGE, the research team conducted a systematic performance evaluation of 95 distinct LLMs sourced from 59 different clinical AI initiatives. These models were subjected to a comprehensive battery of real-world clinical tasks encompassing the entire patient care continuum, ranging across 14 medical specialties. The tasks included patient triage, extraction of critical information from records, diagnostic reasoning, prognostic forecasting, and administrative functions such as billing code assignment. This extensive benchmarking provides a panoramic view of LLM capabilities and limitations in diverse clinical scenarios.

One of the more innovative features of BRIDGE is its public and continuously updated leaderboard hosted on the Hugging Face platform. This dynamic leaderboard catalogs the performance metrics of over 100 LLMs, enabling stakeholders including clinicians, health administrators, and AI developers to track comparative model efficacy in near real-time. The leaderboard thus fosters transparency and spurs iterative improvements by highlighting strengths and vulnerabilities within specific clinical tasks or language domains.

Another salient discovery made possible by BRIDGE is the identification of variability in AI performance across different medical specialties. Given that the benchmark corpus includes nine languages, the tool also illuminates disparities in model effectiveness when dealing with non-English clinical texts. This multilingual adaptability is particularly crucial as healthcare becomes more globally interconnected, underscoring the urgent need to develop culturally and linguistically sensitive AI applications that avoid exacerbating health inequities.

The scientific rigor of BRIDGE is underscored by its deep collaboration among experts spanning pharmacoepidemiology, pharmacoeconomics, clinical medicine, and computational modeling. The team includes senior authors such as Jie Yang, PhD, and Joshua Lin, MD, along with co-first authors Jiageng Wu and Bowen Gu, whose collective expertise was critical in ensuring the benchmark’s relevance and accuracy. Such interdisciplinary engagement is vital for bridging the gap between AI innovation and clinical applicability.

BRIDGE’s architecture and methodology leverage advanced computational simulation and modeling techniques, facilitating nuanced task designs that mimic real clinical workflows. This approach allows the benchmark to capture the dynamic and context-rich nature of clinical text interactions, incorporating elements like colloquial doctor-patient exchanges, complex diagnostic narratives, and procedural documentation. Consequently, BRIDGE functions as a high-fidelity proxy for real healthcare communication scenarios, offering a much-needed calibration tool for medical LLMs.

Funding generously provided by the Patient-Centered Outcomes Research Institute, the National Institutes of Health, and institutional scholarships reflects the strategic priority placed on refining AI’s role in healthcare delivery. Moreover, the rigorous conflict of interest disclosures and adherence to institutional compliance underscore the study’s commitment to transparency and ethical research standards. These factors enhance the credibility of BRIDGE as a benchmark tool destined to influence clinical AI development profoundly.

Importantly, BRIDGE is more than a passive evaluation tool—it is a catalyst for elevated AI design tailored to the clinical domain. By exposing the blind spots and differential performance across specialties and languages, it empowers AI developers to iterate more purposefully, embedding clinical nuance and real-world complexity into model training. This iterative feedback loop has the potential to accelerate the maturation of AI models from theoretical capabilities to practical clinical decision-support systems.

The release of BRIDGE is poised to address one of the persistent challenges in clinical AI—trust. Reliable understanding of patient-care language is paramount to fostering clinician confidence in AI-assisted diagnoses, prognoses, and patient management recommendations. The benchmark’s capacity to expose and rectify shortcomings before clinical deployment mitigates risks of errors caused by misinterpretation of nuanced clinical text, thereby safeguarding patient safety and improving care outcomes.

In closing, BRIDGE exemplifies a paradigm shift that acknowledges the inherent complexities of clinical language and seeks to elevate the fidelity of AI’s interpretative functions accordingly. As healthcare continues its digital transformation, integrating intelligent systems into everyday practice demands benchmarks as sophisticated and reflective as the environments they serve. BRIDGE sets a new gold standard in this endeavor, bridging the divide between cutting-edge AI performance and meaningful clinical utility.

Subject of Research: People

Article Title: BRIDGE: benchmarking large language models for understanding real-world clinical practice texts

News Publication Date: 17-Jun-2026

Web References:

References: Wu, J. et al. “BRIDGE: Benchmarking Large Language Models for Understanding Real-world Clinical Practice Text” Nature Biomedical Engineering DOI: 10.1038/s41551-026-01719-2

Keywords: Artificial intelligence, machine learning, clinical medicine, large language models, electronic health records, multilingual AI, clinical text comprehension, medical AI benchmarking, healthcare AI, patient care AI

AWS targets software release bottlenecks with DevOps Agent update

17 June 2026 at 16:00

The problem with software development today may no longer be writing code. With AI coding assistants generating code faster than ever, the bigger challenge is reviewing, testing, and safely releasing it.

AWS is betting that software teams need help with that part of the process, adding release management features to its DevOps Agent.

The new features, currently in preview, automatically assess code changes against organizational standards, identify potential release risks, and generate tests tailored to individual changes before they reach production.

The release readiness feature, in particular, runs the code in an AWS-managed isolated environment, executing lightweight user journey tests to verify the software builds, runs, and passes basic functional checks before the change enters the pipeline, the company wrote in a blog post.

The findings of these tests can be viewed through the DevOps Agent console, as comments on pull requests in GitHub or GitLab, or can be invoked directly through IDEs via Kiro or the Claude Code plugin, it added.

Targeting AI-era software delivery bottlenecks

Running code in isolated environments and delivering the results directly through developer tools helps address two longstanding challenges in software delivery, said Pareekh Jain, principal analyst at Pareekh Consulting.

It enables teams to validate how code changes behave before deployment, catching issues that static analysis may overlook, while reducing context switching by embedding findings into existing workflows, in turn accelerating fixes, Jain said.

The analyst pointed out that the release readiness capability addresses a key bottleneck in AI-driven software development: “While AI coding agents can generate code quickly, reviews, compliance checks, dependency validation, and release approvals still slow deployment.”

“By automatically checking code changes against internal standards, security policies, and dependency impacts, AWS helps developers, DevOps teams, and SREs identify issues earlier, reduce manual review effort, and improve release confidence,” Jain added.

These gains in productivity for developers could also translate into tangible business benefits for CIOs, according to Jain.

“Release readiness as a feature could help enterprises capture more value from AI-generated code while reducing operational overhead by eliminating the need for additional QA and DevOps resources. This means that they can accelerate software delivery without sacrificing reliability,” the analyst noted.

Autonomous testing before merging code

While release readiness reviews focus on assessing whether a code change is safe to move through the delivery pipeline, AWS is also adding a separate feature aimed at validating how those changes behave in production-like environments.

Named autonomous release testing, the new capability generates and runs change-specific test plans for web and API-based applications in customer-provisioned, production-like environments before the change actually merges, the company wrote in the blog post.

For Jain, autonomous release testing is “even more” important for developers and SREs as it “automates one of the most time-consuming parts of software delivery.”

“Developers spend less time creating and maintaining tests, while SREs benefit from fewer rollbacks and improved system reliability,” Jain said.

These benefits stem from the feature’s ability to automatically generate tests tailored to individual code changes, covering functional correctness, behavioral regressions, and integration scenarios that might otherwise require significant manual effort, Jain added.

However, AWS is not alone in trying to bring AI deeper into the software delivery lifecycle.

Microsoft-owned GitHub has been expanding Copilot’s code review capabilities, allowing the service to automatically review pull requests, suggest fixes, and provide feedback directly within developer workflows.

Google, meanwhile, has been steadily broadening the scope of Gemini Code Assist beyond code generation to support software development tasks such as code review and developer assistance.

AWS’s differentiation, though, according to Jain, lies in tying those capabilities to release management and operational workflows that span development and production environments.

Availability and pricing

For development teams interested in evaluating DevOps Agent’s new capabilities, AWS said both features are available in preview at no additional cost in the US East (N. Virginia) region.

AWS DevOps Agent, billed per agent-second, is included in the AWS Free Tier for new customers.

Additionally, new AWS DevOps Agent customers receive a 2-month free trial starting with their first operational task after general availability.

Each trial month includes up to 10 agent spaces, 20 hours of investigations (incident response), 15 hours of evaluations (incident prevention), and 20 hours of on-demand SRE tasks (chat), the company said.

Once those limits are exhausted, customers are charged based on consumption, with investigations, evaluations, and on-demand SRE tasks each priced at $0.0083 per agent-second, AWS added.

A prerequisite for using the new release management features includes connecting at least one GitHub or GitLab repository to an AWS DevOps Agent Space.

Z.ai pitches GLM-5.2 for long-running software engineering tasks

17 June 2026 at 11:32

Z.ai has released GLM-5.2, an MIT-licensed open-source AI model designed for long-running software engineering tasks, as the Chinese company seeks to challenge proprietary coding models on cost and performance.

The company said GLM-5.2 ranked just behind Anthropic’s Claude Opus 4.8 on FrontierSWE, a long-horizon coding benchmark, trailing it by 1%. Z.ai said the model also edged out OpenAI’s GPT-5.5 by 1%.

Z.ai said GLM-5.2 supports a one million-token context window with up to 131,072 output tokens, positioning it for agentic coding workflows that require reasoning across large codebases.

The company is also making an efficiency argument. It said GLM-5.2 uses a technique called IndexShare, which reduces per-token compute by 2.9 times at a one million-token context length. It also said changes to the model’s multi-token prediction layer increased the acceptance length for speculative decoding by up to 20%.

The changes are aimed at a practical problem for developers: long-context coding agents can be expensive to run when they are asked to work across large repositories.

Enterprise appeal

GLM-5.2’s clearest appeal is that it pairs stronger coding capabilities with the cost advantages of an open-source model. But capability alone will not be enough to make it a credible alternative.

“Western enterprises will want independent benchmark validation, successful deployments at global enterprises, strong security and governance controls, and long-term support commitments,” said Pareekh Jain, CEO of Pareekh Consulting.

Jain said the fastest route to enterprise credibility would be hosting by a major cloud provider like AWS. That would allow customers to use the model under standard enterprise terms, with service-level commitments and compliance certifications.

Tulika Sheel, senior VP at Kadence International, said GLM-5.2 would also need to prove it can operate as a stable enterprise product.

“Demonstrated success in real-world deployments and transparent governance will be just as important as benchmark scores,” Sheel said.

The performance and cost claims will also need to hold up against established models.

“Enterprise leaders generally consider two major factors when evaluating new models,” said Lian Jye Su, chief analyst at Omdia. “First, they look at overall performance against competitors, where GLM-5.2 performs well in long-horizon agentic coding and software engineering. Second, they look at the cost of adoption. As an open-source model, GLM-5.2 has clear cost advantages.”

Su said the model could appeal to engineering teams under pressure to control AI costs. It may also attract open-source advocates and companies with significant operations in Asia-Pacific.

But the claims still need wider validation, particularly around hallucination control and coherence during extended tasks. These are critical issues for enterprises considering AI coding agents, which may need to work across large codebases and multi-step software engineering workflows.

Jain said the one million-token context window could be useful for large codebase analysis. It could also help with legacy modernization projects and complex engineering documentation.

He said long-context capability may also help with audit logs or legal contracts, where splitting material into smaller chunks can create errors across document boundaries. But for everyday coding tasks, effective retrieval systems may matter more than very large context windows, making some of the benefits more limited in practice.

Governance risks

The governance question depends largely on where the model runs.

Sheel said enterprises should evaluate GLM-5.2 as they would any strategic technology partner, rather than as a standalone model. That means looking at where data is stored and whether the model can be used in environments customers control.

That deployment choice is central to the risk calculation, according to Jain. Because GLM-5.2 is available under an MIT license, companies can download the weights and run them on their own infrastructure, reducing the need to send sensitive data to Z.ai.

“The risk flips completely if you use Z.ai’s hosted API instead,” Jain said.

He said Chinese national security rules could require domestic companies to cooperate with government requests, making hosted use difficult for regulated industries or workloads involving sensitive data.

Su said the issue is not limited to Chinese vendors. Recent restrictions affecting access to some Anthropic models have also highlighted the risk that enterprises may have limited control over the availability of AI services from foreign providers.

“Selecting solutions from American and Chinese AI vendors does expose non-US Western enterprises to additional risk of having zero control over the availability and uptime of these models,” Su said.

New Tomography-Based Marker Advances Accuracy of Gastric Cancer Prognosis

16 June 2026 at 23:16

A Revolutionary Biomarker Emerges from CT Scans, Offering New Hope in Gastric Cancer Prognosis

In a groundbreaking study spearheaded by researchers at the State University of Campinas (UNICAMP) in São Paulo, Brazil, a novel biomarker has been identified that could transform prognostic assessment for gastric cancer patients. Gastric cancer—ranked as the fifth most prevalent cancer worldwide—has long posed a challenge in predicting disease progression accurately. This innovative marker, derived from routine computed tomography (CT) imaging data, integrates complex measurements of visceral fat and muscle radiodensity to stratify patient risk more effectively than traditional tumor staging alone.

The multidisciplinary team, drawing expertise from both the Faculty of Medical Sciences (FCM) and the Gleb Wataghin Institute of Physics (IFGW) at UNICAMP, embarked on this research with backing from multiple grants awarded by the São Paulo Research Foundation (FAPESP). Their efforts culminated in the development of what they have termed the Visceral Muscle Difference (VMD) marker—a composite variable that captures metabolic and inflammatory properties of patient body composition using quantitative imaging parameters.

Conventionally, gastric cancer prognosis centers around tumor staging, an approach focusing primarily on the characteristics and spread of the tumor itself. However, this research introduces a paradigm shift by emphasizing the patient’s overall physiological state—not just the malignancy. The investigative team, including Professor José Barreto and co-advisor Jun Takahashi, advocates a holistic perspective that scrutinizes how body composition influences cancer outcomes, highlighting that tailored treatment must address the patient’s systemic condition to improve survival.

Central to the study was the analysis of data collected over a decade from 461 patients treated for gastric cancer at UNICAMP. Researchers meticulously analyzed their CT scans, quantifying radiodensity values of visceral adipose tissue and skeletal muscle. Radiodensity, an indicator of tissue’s capacity to attenuate X-rays during CT scanning, holds clues to underlying biological processes such as inflammation and metabolic health—factors increasingly recognized as critical modifiers of cancer progression.

By integrating these radiodensity values into a single metric, the VMD marker captures the complex interplay between fat and muscle tissue states in cancer patients. Intriguingly, the research reveals an inverse prognostic relationship: elevated radiodensity in adipose tissue correlates with poorer outcomes, possibly signalling inflammatory activation within the fat stores, while higher muscle radiodensity aligns with better survival rates, reflecting preserved muscle quality.

Quantitative analysis demonstrated striking survival disparities based on VMD scores. Patients with elevated VMD—a signifier of detrimental body composition—experienced a median survival of just 13.8 months, starkly contrasted with 58.5 months for those exhibiting healthier VMD profiles. This prognostic ability surpasses traditional staging, offering oncologists a powerful tool to identify high-risk patients who may require intensified or alternative therapeutic approaches.

The robustness of the VMD marker is further enhanced by its design, which strategically utilizes the difference between fat and muscle radiodensity rather than relying on absolute values for each tissue. This approach mitigates variability introduced by different CT scanner calibrations or technical inconsistencies, ensuring more reliable clinical implementation across diverse healthcare settings.

Harnessing advanced artificial intelligence techniques, the team employed machine learning algorithms to sift through the extensive imaging and clinical data. Unlike traditional univariate analyses, this methodology enabled rapid testing of multiple radiodensity combinations, refining the marker until it achieved optimal prognostic precision. “Teaching the machine to align with expert clinical insight while scaling data analysis exponentially was key,” explains Takahashi.

The implications of VMD extend beyond prognostication. Integrating this biomarker into clinical workflows could revolutionize treatment decision-making by unveiling the patient’s metabolic and inflammatory status—critical determinants often overlooked in standard cancer care. Personalized treatment regimens could emerge whereby aggressive chemotherapy is selectively administered to those with high-risk VMD profiles, whereas patients with favorable metrics might avoid unnecessary toxicity post-surgery, fundamentally improving quality of life.

Despite these promising findings, researchers caution that the study’s retrospective nature necessitates validation in prospective, multicenter cohorts encompassing broader demographics. Ensuring reproducibility across different populations and clinical environments is essential before VMD can be fully incorporated into routine practice. Moreover, the potential to modify a patient’s body composition profile therapeutically remains an open question, with ongoing investigations exploring whether nutritional or metabolic interventions can positively impact prognosis.

This study situates itself firmly within the evolving landscape of precision oncology, where understanding the host’s systemic biology complements tumor biology to refine cancer management. By leveraging data from standard CT scans—already integral to patient assessment—the VMD marker offers a cost-effective, readily accessible addition to the oncologist’s toolkit without imposing extra procedural burdens on patients.

Early exploratory studies initiated by the team suggest that the predictive value of the VMD marker may extend to other cancer types, potentially heralding a universal biomarker of cancer-related frailty and inflammation. As these lines of research mature, clinicians may soon navigate cancer treatment armed with unprecedented insights into the intricate interplay between tumor and host, tailoring therapeutics with unparalleled precision.

The diligent efforts of the UNICAMP team, supported by FAPESP, exemplify how interdisciplinary collaboration, cutting-edge technology, and patient-centered philosophy can converge to solve complex medical challenges. Their work opens a new chapter in gastric cancer prognosis, where the narrative shifts from focusing solely on the tumor mass to embracing the multifaceted biological portrait of the patient as a whole—paving the way for a future where personalized medicine is truly realized.


Subject of Research: Biomarker development for prognosis in gastric cancer utilizing CT scan-derived body composition radiodensity variables

Article Title: Determination of a new gastric cancer mortality predictor based on body composition radiodensity variables

News Publication Date: March 21, 2026

Web References:

References:

  • Original article published in Clinical Nutrition ESPEN, 2026

Image Credits: FCM-UNICAMP

Keywords:
Gastric cancer, biomarker, prognosis, radiodensity, visceral fat, muscle, CT scan, body composition, machine learning, personalized medicine, inflammation, metabolic state

SpaceX’s planned $60 billion deal for Cursor raises questions for CIOs

16 June 2026 at 21:03

When SpaceX on Tuesday officially announced its plan to purchase AI coding startup Cursor for $60 billion in stock, as it had predicted it would do in April, it presented CIOs and developers with a little good news, a little bad news and a massive pile of uncertainty. 

The details of the proposed acquisition were virtually identical to the terms announced in April, even retaining the $10 billion consolation prize for Cursor should SpaceX back out of the deal.  

But for CIOs and developers, the increasing probability of the deal happening is forcing them to make long-term decisions without many long-term answers about what is likely to happen to Cursor, which says its coding agents are used by 64% of Fortune 500 companies.

But whether the deal is good news for Cursor’s customers, or even those of its rivals, is an open question.

Arnal Dayaratna, research VP for software development at IDC, is firmly in the good news camp. He argued that the main element holding back the company, which he estimated brings in about $2 billion in annual revenue, was access to GPUs. And, he said, SpaceX’s xAI has the ability to resolve that problem.

It’s all about the GPUs

“The implication is that Cursor can get better because it will get better access to more compute, in the form of GPUs. That was what Cursor was struggling to obtain,” Dayaratna said, adding that Cursor joins both Anthropic and Google in aligning with xAI. 

“It is bad news for Anthropic,” he said, pointing out, “[Elon] Musk figured out that GPUs were the limiters, the bottleneck. Not human talent: compute. And it’s not only about GPUs. It’s about the data centers,” as well as the mechanisms needed to support data centers, including electricity access, cooling apparatus, and zoning rights.

“Zoning rights are very difficult to obtain in the United States, and Elon has been able to leverage his political capital” to obtain those rights, Dayaratna said.

Dayaratna also commented on the highly unusual tactic of a company pre-announcing an acquisition and then announcing it “officially” two months later. The reason, he suggested, is that Musk didn’t want the acquisition to delay the SpaceX IPO, but he did want potential investors to know about it. “It gave the IPO more legs, even though it was not formally a part of the IPO. He wanted to socialize it before it happened,” he said.

Jason Andersen, principal analyst at Moor Insights & Strategy, took a far more cautious approach and predicted, “enterprise customers will be very concerned.”

Time for CIO due diligence

“xAI’s models and treatment of guardrails are very different than what Cursor has stood for,” Andersen said, and the key issue involves model choice. “Will Cursor be able to point at models other than Grok? If that is the case, it could go towards helping customers be OK with things for a while,” he said. 

But Andersen stressed the words “for a while.” He argued that Cursor rivals have gotten more sophisticated, which could give enterprise CIOs more alternatives.

“The tooling options from the classic enterprise vendors have gotten really good, and also have a number of features that enable better governance and teaming. For example, Kiro from AWS is already a worthy competitor to Cursor, but there have also been major improvements from Google and Microsoft this year,” Andersen said. “I’d venture to say that Cursor was already facing a substantial competitive challenge in the enterprise, especially as the vibe coding movement lost some steam towards agents that enable so much more developer capability.”

Andersen added, “A lot of SpaceX’s valuation is pinned to xAI and there wasn’t enough IP there for it to be long-term competitive with Anthropic or OpenAI without rapidly injecting new technology.”

Shashi Bellamkonda, principal research director at Info-Tech Research Group, said the current period of due diligence gives CIOs opportunities to ask difficult questions.

“I do believe that enterprise customers will start to ask harder questions now, especially if more of the processing starts moving through Grok or xAI infrastructure,” Bellamkonda said, but he stressed that he does see a SpaceX deal helping Cursor.

“Cursor is already carrying a lot of LLM cost and if SpaceX and xAI can give it access to more compute and a faster, improved Grok model, customers could eventually get better performance at a lower cost. Grok is getting faster and more accurate, and under SpaceX there may be more enterprise appetite for xAI than xAI had on its own,” Bellamkonda said.

Questions about data privacy

But Bellamkonda also pointed to the trust issue, specifically asking whether Cursor would be allowed to continue its zero-data-retention policy under the new ownership.

“Enterprise users with sensitive codebases will want to understand exactly where their data is going, who has access to it, and whether any prompts, code, metadata, or embeddings are touching SpaceX or xAI systems,” Bellamkonda said. “Zero data retention is only valuable if customers believe the controls still apply across the new infrastructure. If they can preserve Cursor’s privacy posture while using xAI and SpaceX compute to improve the product, this could be a very strong outcome for customers. If the data governance is unclear, enterprise buyers will hesitate.”

Justin Greis, CEO of consulting firm Acceligence, echoed Bellamkonda’s concerns.

“For many enterprise customers, Cursor’s zero-data-retention policy was not simply a security feature. It was a foundational part of the procurement and approval process,” Greis said, pointing out that security teams, legal departments, compliance officers, and executive leadership all became more comfortable adopting AI-assisted development because they believed their source code, prompts, and proprietary intellectual property would not be retained, stored, or repurposed.

“Whenever ownership changes, customers naturally revisit those assumptions,” he said. “I would expect enterprise customers to immediately seek clarity on whether existing zero-data-retention commitments remain unchanged, whether those commitments continue to be contractually enforceable, and whether any future modifications could be introduced through changes to terms of service or product strategy.”

Reassessing platform risk

Another concern is whether the move will create greater vendor concentration, and whether that will increase risk exposure. 

“Many organizations are already concerned about becoming overly dependent on a small number of AI providers. If Cursor becomes more tightly integrated into a broader SpaceX technology ecosystem, some enterprises may worry about reduced flexibility and fewer alternatives. I suspect this will be a continued question with SpaceX’s recent IPO and growth plans,” Greis said.

Additionally, he pointed out, “AI coding platforms are rapidly becoming part of critical software delivery infrastructure. When organizations standardize on these tools, they are making a long-term platform decision that influences developer productivity, software quality, security processes, and engineering workflows. A change in ownership naturally prompts a reassessment of platform risk, roadmap alignment, and long-term strategic direction.”

As well, Sanchit Vir Gogia, chief analyst at Greyhound Research, noted, “zero data retention survives only where it stays contractual, auditable, enforceable and fenced from affiliate use. The deeper point is what Cursor has become. It is no longer a developer convenience. It sits inside the act of software creation, close to the intellectual-property bloodstream of the enterprise. That is a control plane, and control planes change hands rarely and consequentially.”

Gogia added that even before an acquisition, Cursor was already weakening its data guarantee. “Even now the promise is layered. Cursor’s own disclosures show that standard Privacy Mode still permits some code data to be stored for product features, while only the stricter legacy setting retains nothing. Zero is the exception, not the default.”

Shipping enterprise-quality code with AI agents

16 June 2026 at 10:00

Developers are caught between the joy — or pressure — of using agents to ship 10x faster today and the dread of how they will maintain that code tomorrow. The gap between “vibe” code and code that can be deployed to millions of users is vast and easy to underestimate. Closing the gap requires care, expertise, and effort, with the payoff coming later. Agents are able to complete increasingly complex programming tasks but without the quality we need. What’s missing, and how can we fill the gap?

agentic coding quality gap - sonar

Sonar

Why agent-generated code degrades: the bloat problem

Enterprise code has to clear three bars: it must be maintainable, reliable, and secure. Out-of-the-box AI agents can miss all three. Let’s focus on the biggest and most visible maintainability issue, which is bloat: redundant validation, defensive checks that cannot fire, near-duplicate functions, dead code that nothing removes. A None check on a parameter typed as dict. A try/except around a call that never throws. Two functions, identical except for the negation in their return statement.

Bloat varies dramatically by model. Sonar’s LLM Leaderboard runs every frontier model through 4,400+ Java tasks and analyses the code generated. To complete the benchmark, GPT-5.4 High generated 1,159,000 lines of code at an 81.05% pass rate, while Claude Opus 4.7 Thinking generated only 336,000 lines of code to return a better than 82.52% pass rate. Different models generate dramatically different code to achieve similar outcomes.

Bloat is not just messy. Carnegie Mellon researchers studied 807 open-source projects that had adopted Cursor, matched against 1,380 controls, measured by SonarQube. A short-term velocity gain disappeared by month three, while static analysis warnings rose 30% and code complexity rose 41% — both persistent. The harder it became to change the codebase and the more bugs it contained, the more the velocity was dragged down. Any experienced developer will know how this goes: quality problems compound until the code feels impossible to change and the only option is the dreaded rewrite.

Three forces produce bloat once a model is in use:

  1. Agents do not feel the maintenance burden. Armin Ronacher, the creator of Flask, made the point on the Pragmatic Engineer podcast in late April. Humans feel the cost of bad code over time, and as Ronacher put it, “if the pain gets too big, you as a human are incentivized to fix the cause of your pain” — so we refactor. Agents do not. They obliviously extend bad structure indefinitely. A senior engineer’s job is to say no to unnecessary abstraction. The agent has no equivalent reflex.
  2. Training rewards apparent completeness. Pretraining corpora are full of explanatory material — Stack Overflow answers, tutorials, README snippets — deliberately self-contained and verbose. Post-training compounds the effect: human raters prefer outputs that look thorough, so models learn that “comprehensive” reads as better. When uncertain which edge case matters, the safe move is to handle all of them. Each guard is locally defensible. The aggregate is bloat.
  3. Iterative generation has no deletion pressure. Agents add but rarely delete. Removing dead code does not make any test go green, so superseded functions accumulate alongside their replacements. SlopCodeBench, a March 2026 benchmark across 11 coding models, found rising structural complexity in 80% of trajectories and rising verbosity in 89.8%. Agents continue to patch bad code, treating every task as if it’s their last.

AC/DC: the loop that compensates

What closes the gap is a loop around each iteration of agent work. The agent does what it is good at — generating code — and our job is to wrap that with three steps the agent cannot reliably do on its own. At Sonar we call this the Agent Centric Development Cycle, or AC/DC: guide, verify, solve.

Guide

Many teams overcorrect on context. They paste the style guide, three years of architectural decisions, and the entire onboarding doc into the agent’s instructions and expect output to improve. ETH Zurich researchers tested this and found the opposite: large context files often reduced task success against no context at all, and added 20% or more to inference cost.

Keep agent-facing context short — under 200 lines is a useful heuristic — and restrict it to fundamentals that can’t easily be inferred from the code: naming conventions, architectural invariants, what has been tried and failed. However, this will only get you so far, so make sure to provide specific context for each task. If you have architectural expectations, don’t expect the agent to guess them. Software architecture tools can be used to provide additional context in the guide phase.

Task shape matters too. Break the work into steps and agree on a plan; ask the agent to provide three solutions and evaluate the impact on quality of each. There is no perfect software architecture, and you understand the trade-offs in your codebase best, so think critically about the changes before they happen. Without this, the agent will confidently pick an option, seemingly at random, and the further it goes the harder it is to “unpick.” If you want to test this, ask three instances of your preferred agent to complete a task that involves some polymorphism and watch each one confidently suggest a different solution.

Verify

The most expensive verification mistake is doing it last. Reviewing 200-line pull requests (PRs) after the agent is done is the dynamic behind the Faros/DORA figures Addy Osmani highlighted: 98% more PRs merged in high-adoption teams, review times up 91%. Verification inside the loop is different. Unit test runs, static analysis, and security scanners produce output the agent can act on. This is where AI-native tooling belongs: purpose-built for the agent to invoke, not just for humans to consult through a UI.

Human reviewers cannot keep up. When agents merge twice as many PRs per week and each one takes nearly twice as long to review, doubling the review staff still leaves you behind. Automated verification is the only response that scales. Fast feedback has always been a fundamental tenet of good software engineering. Feeding it directly back to the agent protects the developer from simple mistakes and leaves them headroom to work on the harder ones.

Solve

If verification happens within the agentic loop, the agent can fix any issues whilst the code is being generated without expensive remediation steps. Static analysis tools can guide the agent on how to resolve the issue quickly. Some cases need human judgment — a None check at a system boundary may document a real precondition. But most of the work is mechanical. Automate the obvious fixes and let engineers spend their attention on the cases that are not.

The investment that compounds

Better models will keep arriving. They may not change the mechanism of bloat or the dynamics of compounding decay. The loop is what does — bounded tasks, sharp context, in-loop verification, and a deliberate “solve” step to clear bloat before it accumulates.

The same logic governs how autonomy should expand. Reduce human interventions only when the agent’s guide, verify, and solve cycle is making them redundant. Our biases can sting us here: an agent’s ability to write code can lead us to agree with it more than we should. Don’t trust blindly; wait for the evidence.

The teams that will be shipping enterprise-quality code with AI agents in 18 months are not the ones running the “best model.” They are the ones treating workflow as the engineering investment, with the seriousness once given to build systems and CI. The model is the tool, the workflow is the discipline. That is where the durable advantage compounds.

—

New Tech Forum provides a venue for technology leaders—including vendors and other outside contributors—to explore and discuss emerging enterprise technology in unprecedented depth and breadth. The selection is subjective, based on our pick of the technologies we believe to be important and of greatest interest to InfoWorld readers. InfoWorld does not accept marketing collateral for publication and reserves the right to edit all contributed content. Send all inquiries to doug_dineley@foundryco.com.

OpenAI buys Ona to help rein in AI agents

12 June 2026 at 21:01

CIOs and CISOs have many strategic and operational fears when it comes to unleashing fully-autonomous agents on tasks and hoping that everything works out. Will the agent start to delete critical files? Will the agent go off on a mission tangent and generate a massive token bill for the team when they return the next morning? Will it be tricked by a state actor and engage in malicious actions?

To help alleviate those concerns, OpenAI announced on Thursday that it has agreed to acquire Ona, a 79 person cloud development environment (CDE) provider formerly known as Gitpod, to accelerate its efforts to make agentic AI enterprise-friendly. 

An OpenAI statement said Ona’s technology “provides secure, persistent environments where agents can access the tools, systems, and context they need to make progress over time. By bringing Ona to OpenAI, we will expand Codex beyond work tied to a single device or active session and help more organizations deploy agents securely in production.”

An Ona statement attributed to CEO Johannes Landgraf shared similar sentiments.

“Ona brings the building blocks agents need for enterprise work: trusted, customer-controlled cloud environments where work continues across devices, inside the systems where software actually lives,” Landgraf said. “OpenAI brings frontier intelligence, product polish, and a scale of research and distribution we could never reach alone.”

Landgraf’s statement did not provide any annual revenue numbers, but did hint, without naming, at some large customers. “Since the beginning of the year, weekly Ona agent sessions have grown 13x in production across some of the world’s most demanding institutions: the oldest bank in the US, one of Europe’s largest pharma companies, one of Asia’s largest sovereign wealth funds and many others,” he wrote. “The largest enterprises out there love the platform and are expanding more rapidly than ever before.”

Arnal Dayaratna, research VP for software development at IDC, said IDC’s figures for Ona put its annual revenue for 2025 at “roughly $7 million.” He speculated that Ona’s revenue for 2026 would be higher: “Let’s say it’s $15 million. I am being generous. Maybe it’s really $10 million or $12 million.”

Dayaratna said if he uses a standard acquisition price of roughly a multiple of 30 times revenue, then depending on the actual 2026 figure, “that comes to $450 million or $500 million or so.”

But IDC sees this being a potentially good move for OpenAI, regardless of the specific acquisition price, given that OpenAI had the classic “buy or build” challenge. 

OpenAI has a substantial Codex effort, Dayaratna said, but what they lack is a safe area to protect enterprise autonomous agent efforts. “This is outside of what OpenAI has now. These are secure environments where agents can have memory and operate securely,” he said. “This is the kind of technology that one would expect to be needed, but I don’t know how good it is, to be honest.”

Gartner’s First Take, published today, noted that the acquisition will bring Codex “the essential scaling capability it lacked,” but also pointed out it forces some difficult decisions on enterprises: “Software engineering leaders must weigh the benefits of a vendor-specific integrated stack against the flexibility of staying vendor-agnostic.”

In addition, Gartner wrote, “This acquisition appears to be OpenAI’s response to Anthropic supporting self-hosted sandboxes in Claude Managed Agents, starting May 2026.”

Tom Findling, CEO of Conifers.ai, said he also sees OpenAI’s fear of Anthropic playing a meaningful role in this deal. 

“It feels like a move to keep pressure on Anthropic, especially as Claude Code gains traction with developers and enterprise buyers,” he said. “So I’d read this less as OpenAI taking out a small competitor and more as OpenAI trying to make sure Codex is enterprise-ready before Anthropic gets too far ahead. In the enterprise market, the battle is not just who has the smartest coding model, but who can make AI agents safe and useful enough for big companies to actually deploy.”

He added, “I don’t think this means OpenAI suddenly needs help making Codex better at writing code. The bigger issue is making Codex work inside real enterprise environments, where security, access controls, persistent cloud workspaces, audit trails, and integration with existing developer workflows matter just as much as the model itself. Ona gives OpenAI some of that missing plumbing.”

Jason Andersen, principal analyst for Moor Insights & Strategy, echoed the concerns about Anthropic.

“To be honest, I think it reinforces what I think, which is that OpenAI and Codex have given a lot of ground to Anthropic and Claude Code, who are winning right now,” he said. “But again, this is not about the market today, I think it’s about how OpenAI will need to position itself as more than just a model as we see the incumbent players, particularly Microsoft, bolster their enterprise coding infrastructure story.”

Andersen said that Moor doesn’t have any strong basis for a guess on the financials, but added, “I am going to assume it was a fairly high multiple, but on a small base. I would not speculate on an amount, but given the enterprise customers that Ona did have, it may be more than we think.”

He also reinforced the idea that OpenAI is going to need help to achieve its own objectives.

“We continue to see that AI adoption is strongest in coding, and other use cases are not as far along,” he said. “So, if you are a general-purpose AI company like OpenAI, you need to double down on development use cases. The meaningful investment and spending on development is happening at the enterprise level, and those customers have more demands for governance, security, etc. than Codex or Claude code can handle.”

That said, he noted, “what you’re seeing is traditional software and cloud plays building out the coding and ops infrastructure around the popular models. That increased competition, while good for selling tokens, is still keeping OpenAI and Anthropic on the outside looking in. So, OpenAI and Anthropic need a stronger enterprise dev story, or they are just another model that could be easily replaced.”

Jeremy Roberts, senior director at Info-Tech Research Group, said that he also sees this as likely a good move for OpenAI.

“OpenAI is growing up a little bit,” and they may be falling behind Anthropic, Roberts said. “I see Ona as a boring company, but not in a bad way. They are not flashy, but absolutely necessary.”

Ona is delivering a workspace for Codex that an enterprise can run in its own virtual private cloud, with governance and persistence and an environment where the company can apply their own controls including log management, credential management and resource access, he said. “It is a bucket for the agents to operate in” where IT can “make sure that access is properly credentialed and is controlled effectively to prevent the model doing what it shouldn’t be doing,” which includes managing read/write protections.

Microsoft open sources AI evaluation framework for enterprise agents

11 June 2026 at 13:36

Microsoft has open-sourced an AI evaluation framework that converts natural-language requirements into executable tests, expanding its push into enterprise AI governance as organizations struggle to validate agent behavior before production deployments systematically.

The framework, called ASSERT (Adaptive Spec-driven Scoring for Evaluation and Regression Testing), generates evaluation scenarios, datasets, metrics, and scorecards from written specifications, product requirements, and governance documents, Microsoft said in a blog post announcing the release.

“Agents fail in ways that are hard to see,” Microsoft wrote in the blog post. “They drift from policy, produce unsafe outputs in edge cases, and behave differently in production than they did in testing. Generic benchmarks do not catch these failures because they are not built around your policies, your agent, or your use case.”

Rather than requiring developers to manually create evaluation suites, ASSERT translates written intent into reusable tests that can be integrated into AI development pipelines, the company said in the blog post.

With ASSERT, Microsoft is entering an increasingly competitive AI evaluation market that already includes platforms such as LangChain’s LangSmith, Braintrust, Patronus AI, Galileo, Arize AI’s Phoenix, and Promptfoo, which help enterprises benchmark, monitor, and validate large language model applications.

Behavioral testing remains immature

The release comes as enterprises rapidly expand AI agent deployments while formal evaluation practices remain the exception rather than the rule.

“Most organizations, in fact, 99% of them, do not evaluate any AI agents pre-production,” said Anushree Verma, senior director analyst at Gartner.

According to Verma, the industry’s next competitive advantage will depend less on advances in reasoning models than on how effectively organizations simulate and stress-test AI agents before deployment.

“The next competitive moat in agentic AI is not about the sophistication of reasoning models or the underlying architecture,” she said. “It will be about the depth and realism of the training environment through agentic simulation, particularly for mission-critical deployments.”

Gartner estimates that by 2029, more than 75% of domain-specific agents designed without agentic simulation in regulated industries will fail to deliver value.

Forrester sees enterprises moving toward behavioral evaluation but says most organizations have yet to make it a formal production requirement.

“Most enterprises are still in an intermediate stage where behavioral evaluation is inconsistently applied rather than treated as a formal production gate,” said Biswajeet Mahapatra, principal analyst at Forrester.

According to Forrester data, more than 45% of organizations are already using AI agents, and another 25% are piloting them, yet many continue to struggle with scaling because of immature governance and limited operational rigor.

“The net is that behavioral evaluation is becoming important, but for most organizations it is still ad hoc or tool-driven rather than a standardized release gate enforced across the lifecycle,” Mahapatra said.

AI judges still need human oversight

Microsoft said ASSERT uses large language models as judges, with model-generated evaluations agreeing with human reviewers 80% to 90% of the time in the company’s internal validation.

That level of agreement can help automate large portions of AI testing, but should not be treated as a standalone governance mechanism, Mahapatra said.

“An 80% to 90% agreement rate with human reviewers indicates strong alignment but is not sufficient as a standalone control for governance or compliance,” he said.

Instead, enterprises should adopt layered oversight where AI evaluates AI at scale while humans retain supervisory accountability for high-risk, regulated, or ambiguous scenarios. Buyers should also watch for bias, consistency issues, and overreliance on a single model acting as both generator and evaluator, he added.

Open source reduces lock-in, not governance risk

Microsoft released ASSERT under the MIT open-source license, allowing organizations to inspect, modify, and integrate the framework into existing AI development workflows.

But open sourcing a framework does not eliminate questions around evaluation neutrality, Mahapatra said.

“Open sourcing under an MIT license reduces lock-in concerns and enables broad interoperability across model ecosystems,” he said. “However, it does not fully eliminate trust or conflict-of-interest questions because the originating vendor still influences how evaluation criteria, scoring logic, and definitions of acceptable behaviour are encoded.”

Instead of relying on a single evaluation framework, enterprises should validate AI systems against multiple evaluation approaches and retain ownership of internal evaluation policies, he said.

Build an agent? Sell an agent

11 June 2026 at 10:00

Modern AI systems have evolved beyond the simple chatbots that quickly became popular. Now they use semantic tools to manage workflows and link machines to machines, providing a flexible and effective framework for the next generation of business automation. What you used to build in Microsoft’s Power Platform or construct inside Biztalk is now an agent, built around large language models (LLMs) that can parse both your data and the APIs that you want to use your data with, orchestrating workflows with a level of autonomy that traditional tooling can’t match.

That shift has offered new opportunities, much like those that came with business platforms like Microsoft Dynamics and Salesforce. Here, tools built to solve one set of business problems could be turned into applications that could be sold to other companies. What worked for you to solve one of your problems could now be an added revenue stream, sold through platform marketplaces that helped customers manage installations and customizations.

Agents are business applications now

Modern agents are much like those business applications. Often developed to solve a specific need, but quicky adopted by organizations and refactored to apply enterprise standards (using tools like the Agent Governance Toolkit and frameworks like Microsoft’s Agent Framework), they’re rapidly maturing and are ready to be shared more widely. The process of sharing needs to be curated and controlled, and, if possible, tied to a revenue stream.

There’s certainly some urgency here. Until recently, subsidized tokens have kept costs artificially low. Now companies like GitHub and Anthropic are moving to a more sustainable (for them) pricing model, increasing the cost of inferencing and squeezing companies’ AI budgets. As a result, switching AI projects away from a cost to a revenue source is high on CIOs’ agendas. If those tuned and trained agents can be sold on a marketplace, then that token budget can be justified.

Microsoft has always been a company built on partner relationships, starting with individual developers and working all the way up to the largest software companies and consultancies. That reach is key to helping partners extract as much value as possible from their agents, as it allows Microsoft to integrate its partner sales tools into its own products and services, as well as into other platforms.

Extending the Microsoft Marketplace for AI developers

We’re already familiar with many of Microsoft’s marketplaces, built into individual tools like Teams, into platforms like Microsoft 365 or Visual Studio, or into the Windows Store. Now the company is doing the same for AI developers, extending Microsoft Marketplace to software agents. Announced at Build 2026, the updated Microsoft Marketplace provides ways to publish code—apps and agents—developed across all of Microsoft’s development platforms, including Copilot Studio, opening the marketplace up to traditional and non-traditional developers alike.

Perhaps the most important aspect of this new Marketplace is its own intelligence, using context to expose your code to the right audience. If you’ve developed an agent for use with Microsoft 365, it will be exposed inside the Microsoft 365 Copilot Agent Store; for Visual Studio, in the Visual Studio Marketplace; or for Teams, in the Microsoft Marketplace. All of these are different views on the same back end, using AI to ensure that the relevant agents are displayed.

Replacing search with Intelligent Discovery

This is extended by another new service, Intelligent Discovery, which adds natural language support to search, using AI to infer user intent and highlight the most relevant tools. Building on the familiar metaphor of the search bar, the initial smart search model offers a freeform way to explore the Marketplace. While there are suggested prompts, they’re not necessary. The search tooling allows you to generate comparisons between tools using your own criteria, with the Marketplace AI generating views based on your requirements.

Microsoft’s aim here is to shift discovery from keywords to use cases, so that buyers can quickly get the tools they need without having to evaluate different solutions, before completing a purchase. By handing that aspect of the buying process over to Marketplace’s AIs, customers can go straight to trials or even to buying agents and applications.

For a tool like this to be successful it needs to be trustworthy. By building it on top of the same development frameworks as your agents, Microsoft can take advantage of the AI guardrails built into Microsoft Foundry as well as low-level tooling like the Agent Governance Framework. Restricting the intelligent search to the Marketplace catalogue reduces the risk of hallucination, as output is grounded in Marketplace data and metadata.

A developer-friendly marketplace

Microsoft is providing tooling to help developers get their listings right. According to Cyril Belikoff, Microsoft’s vice president of Commercial Cloud and AI, “We actually have a separate AI tool that we give to software companies to optimize their listings, called a listing optimizer, funny enough, and that listing optimizer reviews their listing and then provides them with particular guidance on how to best improve it, so that it can be best discoverable in today’s search world.”

You can expect the listing optimizer to be tuned to work with the new Marketplace tooling, but for now it still focuses on traditional search. As Marketplace is a B2B platform, there’s a lower risk of spam applications, but even so, Microsoft remains aware of the possibility of a new system being gamed, and will be rolling out Intelligent Discovery carefully, monitoring its performance as more customers get access over time.

Having a new discovery method is one thing; getting quality AI applications in the Marketplace is another. Microsoft is validating all code submitted, though the criteria will differ between target platforms. An agent built for Teams will be treated differently than one built on Microsoft 365’s WorkIQ. It’s an approach that allows Microsoft to support new standards as they become available.

Alongside its agent development tooling, Microsoft is rolling out a new set of guidelines and processes to help developers get ready to sell their agents. Hosted on GitHub, these offer code templates as well as a link to the App Advisor guidance tools.

Still gaps to fill

This first release of Intelligent Discovery is promising, but some key features are missing. With agent token costs an increasing problem for businesses, it would be nice to see tools that help predict costs, integrating with finops tooling. We’re living in an age of shadow AI, and putting the AI we used to buy with credit cards in Microsoft Marketplace is one way to shine a light on those shadows — bringing the necessary control and governance to AI purchases, and maybe even providing support for site licensing.

Microsoft Marketplace is becoming a useful resource for AI application developers. It encompasses the entire development life cycle: offering tools that can help you build agents, the models that you need to power your agents, and finally a way to monetize your work. There’s a longer-term opportunity here, for both the Marketplace and Intelligent Discovery to offer Model Context Protocol (MCP) interfaces, ensuring that tooling and tool discovery become part of the developer workflow, and making developers aware of new tools that might help solve a problem or simplify a task.

The tokenmaxxing backlash is coming

10 June 2026 at 10:00

I’ve been around long enough to remember when deploying an application meant copying a *.exe file from the developer’s machine right into production. I am not making this up. It was that simple, and that fraught with peril. Applications weren’t complex — they were often not anything more than that simple *.exe file — and the process around deployment didn’t need to be anything complex, but it probably should have been.

Proper deployment of an application is something we’ve learned to do over the years. The process of properly building, testing, and deploying an application has grown more complex for two reasons. First, the process must ensure that every deployment succeeds. Deploying complex applications can be convoluted and challenging, and a strict deployment process ensures everything happens properly and runs correctly. Second, the process must thoroughly test the application to make sure that all the moving parts work together to create a properly functioning application. 

Today’s continuous deployment processes were hard-won from many lessons learned. Eventually, these practices became formalized, even to the point where the Sarbanes-Oxley Act was understood to require that IT departments formally document their deployment processes. 

This kind of governance is what separates professional software development organizations from those that, well, don’t know what they are doing. 

Agentic growing pains

Agentic development is headed in this same direction, but it’s all happening a bit more quickly. It was just a few months ago that people began to use AI to write code seriously. At first, most of us were doing it furtively, having Claude Code find and fix bugs, and then quietly checking in the solutions. Maybe we were a bit hesitant to mention that we had done this, but then we felt guilty about doing it and taking credit, and eventually we mentioned it. But it soon became apparent — like “within a week” soon — that Claude Code was up to the task, and we became pretty open about it. 

Very quickly, it not only became accepted but actually encouraged, and we were off to the races. In a month, everyone was tokenmaxxing.

It almost seems a bit out of control. Sure, there is a lot of code being generated and non-trivial amounts of money being spent, but it isn’t quite clear if the results are worth the effort. I’m not at all sure if anyone can say that the money spent is returning the value needed.

At some point, as an industry, we are going to have to get control of all of this. I fear that there will be a rush to impose governance over the whole thing. This, like deploying an .exe directly, is also fraught with peril. Right now, there appears to be little control over what tools are being used where, how much is being spent for what purpose, and what that spending is actually getting us. 

The governance over our deployment processes was successful and useful because it arose organically. The accepted, codified procedures arose from the lessons that practitioners learned by actually building and deploying applications. We all should work to ensure that a similar process happens with agentic coding.

Developers know best

Because agentic coding is happening so quickly and so furiously, the danger is that a governance process will be imposed over the top just as quickly and furiously. I want to encourage us all to take a deep breath, slow down a bit, and take a close look at what we are doing, and more importantly, how we are doing it. 

Agentic coding will be governed in some manner. It’s critical that we practitioners take the lead in providing that governance, or we’ll have governance forced upon us. We are the ones that know what matters and how the tools should be used. We are the ones with skin in the game and the ones keeping pace with the technology. 

Top-down governance of a technology moving this fast will never be able to keep up. Or as Uri Haramati, co-founder and CEO of Torii says, “The person closest to the tool usually understands why it’s being used, and governance works better when it includes those people instead of trying to control them.”

Copying that *.exe file into production is comically reckless. We don’t do that anymore because we know better. It took time, but we learned the right way to deploy software. Right now, we are in the “copying the *.exe” phase of agentic coding, and we need to figure out the right way to do it before someone comes along and does it for us.

❌