One new mission is setting out to study menstruation in microgravity for the first time ever.

Forty-six years ago, NASA engineers asked Sally Ride if 100 tampons was the right amount to send with her for a six-day spaceflight. Though people laugh at that fact today, there has still never been any scientific study dedicated to studying menstruation in space. But a non-profit called Operation Period aims to change that. Led by Gen-Z researchers, this non-profit works to provide what its founder Manju Bangalore calls "menstrual freedom," which she says would mean everyone can have easy access to menstrual products. Meanwhile, the organization also aims to tackle the wider issues that leave people without such access in the first place. With its upcoming suborbital mission Operation Period-01 (OP-01), this ambitious team is taking their cause into microgravity. On OP-01, the mission's founder will launch to space to conduct the research themselves on a Virgin Galactic suborbital flight in 2027.

In conducting their work here on Earth, Operation Period found that "there were still some of those same gaps in spaceflight medicine," Manju Bangalore, the founder and executive director of Operation Period and research astronaut in training for OP-01, told Space.com. " I want all menstruators to be able to live life with their full dignity and reach their fullest potential, and that includes astronauts."

With a background in physics and astronomical engineering as well as with training in bioastronautics and having spent time working at NASA, Bangalore brings her love of space to this cause. She and Priya Abiram, the Director of Research at Operation Period's Redshift Lab, feel so strongly about their message, even 9 years since the pair founded their non-profit; in fact, with this mission, the two will become some of the youngest South Asian women to travel to space.

"On a personal level, I've always been fascinated by space and human space exploration. It's what's always excited me as a child, and I've kept that curiosity going," Bangalore said. "I didn't think those two missions would ever combine into this. It wasn't something I ever planned, but I'm very grateful to lead this historic mission to advance menstrual health in this way."

And just as this team is excited to bring their research into a suborbital environment, Virgin Galactic is excited to be expanding the range of microgravity science the non-profit supports. "This mission with Operation Period is a powerful example of how Virgin Galactic can continue to support real-time, in-flight scientific investigation into long-overlooked areas of human health, helping advance more inclusive and innovative exploration that delivers insight for both space and life on Earth," Virgin Galactic director of system analysis & research Amber Favaregh said in an emailed statement.

Recently, Operation Period expanded to include a research wing, and this mission will be conducted under that umbrella. The team was not yet able to share specific details on the exact protocol that will be conducted during the mission, information they said will be shared at a date closer to launch, but they did share the current issues that this research aims to begin to address.

Currently, astronauts typically choose to fully suppress their periods during their spaceflights, through hormonal IUDs or oral contraceptive pills. While that is a choice astronauts might continue to make in the future, without data to show the reality of dealing with a period in space, astronauts are left with fewer choices with their own bodies. Comprehensive data on menstruation in space will also be important if astronauts are to complete longer spaceflights or even extended stays on the moon. While the mission has not yet revealed its priorities and exactly what data it will collect, with such limited data on menstruation in space, there is a lot of knowledge to be gained.

While "the data that we have, although limited, says that it is generally safe to menstruate, in terms of long duration missions, we don't have quantitative data," Bangalore said. "We don't have enough data to continue to assist with patient resource allocation for mission planners."

Historic missteps like the "100 questions" moment with Sally Ride highlight an issue that could have big effects on future, longer-term missions. Sure, having a ridiculous number of backup products would ensure that there is no need unaddressed, mass considerations for spaceflight are extremely serious and future missions will need to have better data to know what will be needed in a microgravity environment.

And just like with other science in space, the research conducted in microgravity will also be used on Earth. The pair aim to collect menstruation data that will benefit astronauts as well as people back on our home planet. .

"I think on Earth, there's a lot of gaps right now in menstrual health research," Bangalore said. As just one example, she cited recent findings that menstrual product companies were reporting incorrect absorbency of their products because they were testing products with saline, which is very different from menstrual blood. "This was potentially leading to doctors to underdiagnosed heavy menstrual bleeding, which right now the stats say affects 20% of American menstruators," Bangalore said.

With this being the first mission of its kind, OP-01 will not answer every question that remains about menstruation and space, but it will bring data to a conversation decades in the making. "Our hope is to continue to iterate this research so that we can do future suborbital flights, as well as orbital flights, to continue to create larger data sets," Bangalore said. "I think the point of preliminary studies is to be able to know what questions to ask in the future, so we don't expect that this suborbital flight will solve everything or create all the data that we need, right, but we hope that this will be a good stepping stone."

Momentum for this research was actually sparked by many millions of views on a viral social media video in which Bangalore conducted an early version of a menstrual fluid dynamic experiment in a low-gravity environment aboard a parabolic flight.

This viral moment "ended up being a really cool kind of 'in' to continue talking about destigmatizing periods," she said. "Through that, I got to talk more about the gaps in spaceflight medicine, in terms of menstrual health."