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Normal view

Received — 17 October 2026 ⏭

Engineered TYK2 dependence enables myeloid-selective IL-10 receptor agonism

✇Nature
By: D. Alejandro Canaria · Trang T. T. Nguyen · Huang Huang · Hui Xu · Lili Yue · Yongyao Fu · Hoa Truong · Kerul Patel · Weimei Xing · Jayamary Divya Ravichandar · Cong Xing · Aron L. Martin · George Delidakis · Sylvia Wong · Andrew Pae · Yu Yu · Ramsay Macdonald · Zhiyu Huang · Meagan C. Main · Amanali Rodriguez · Xiaoli Lin · Maria L. Mouchess · Magdeleine Hung · Ellen M. McGlinchey · Lei Chen · Nicole Schirle Oakdale · Brian Carr · Megan L. Koleske · Chingwei V. Lee · Chen Chen · Tangsheng Yi
14 October 2026 at 01:00

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11176-1

A tetravalent nanobody-based myeloid-selective IL-10 receptor agonist recapitulates IL-10’s potent suppression of monocytes, macrophages and dendritic cells while avoiding stimulation of T cells.
Received — 25 July 2026 ⏭

Structures and inhibition of the Crimean–Congo haemorrhagic fever virus polymerase

✇Nature
By: Lu Xue · Jiacheng Gui · Hainei Pan · Fan Wu · Shenghua Gao · Wenhua Kuang · Tiancai Chang · Zimu Li · Binqian Zou · Heyu Zhao · Mei Li · Min Zhou · Hongyu Yuan · Lijun Rong · Peng Gong · Jun He · Zengqin Deng · Manli Wang · Peng Zhan · Xinwen Chen · Xiaoli Xiong
22 July 2026 at 01:00

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10701-6

Structural studies of Crimean–Congo haemorrhagic fever virus (CCHFV) polymerase reveal the structural basis of CCHFV RNA synthesis and highlight druggable sites for designing both nucleoside antivirals and non-nucleoside antivirals.
Received — 9 July 2026 ⏭
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