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Normal view

Received — 25 July 2026 ⏭

RNA synthesis and substrate analog inhibition in the CCHFV polymerase

✇Nature
By: Hengxia Jia · Bo Tang · Shunli Liu · Xin Wen · Fan Wu · Xiao Hu · Hu Zhou · Tingting Chong · Lincan Lv · Qiaojie Liu · Guibo Rao · Mingyu Wei · Xuping Jing · Sheng Cao · Fei Deng · Zhihong Hu · Bo Shu · Rui Gong · Jiqin Wu · Manli Wang · Peng Gong
22 July 2026 at 01:00

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10913-w

RNA synthesis and substrate analog inhibition in the CCHFV polymerase

Structures and inhibition of the Crimean–Congo haemorrhagic fever virus polymerase

✇Nature
By: Lu Xue · Jiacheng Gui · Hainei Pan · Fan Wu · Shenghua Gao · Wenhua Kuang · Tiancai Chang · Zimu Li · Binqian Zou · Heyu Zhao · Mei Li · Min Zhou · Hongyu Yuan · Lijun Rong · Peng Gong · Jun He · Zengqin Deng · Manli Wang · Peng Zhan · Xinwen Chen · Xiaoli Xiong
22 July 2026 at 01:00

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10701-6

Structural studies of Crimean–Congo haemorrhagic fever virus (CCHFV) polymerase reveal the structural basis of CCHFV RNA synthesis and highlight druggable sites for designing both nucleoside antivirals and non-nucleoside antivirals.
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