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Engineered TYK2 dependence enables myeloid-selective IL-10 receptor agonism

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11176-1

A tetravalent nanobody-based myeloid-selective IL-10 receptor agonist recapitulates IL-10’s potent suppression of monocytes, macrophages and dendritic cells while avoiding stimulation of T cells.

RNA synthesis and substrate analog inhibition in the CCHFV polymerase

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10913-w

RNA synthesis and substrate analog inhibition in the CCHFV polymerase

Precise DNA base editing using AlphaFold3-based contact modelling

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10794-z

ContactSeek is an AlphaFold3-driven model that can improve the precision of genome-editing tools.

Optical cooling by interfacial charge transfer in 2D heterostructures

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10662-w

Optical cooling in two-dimensional semiconductor heterostructures is demonstrated through phonon-assisted interfacial charge transfer, enabling cryogen-free thermal management without stringent quantum-efficiency requirements.

In situ polymerized zwitterionic elastomers for efficient and stable perovskite solar cells

Energy Environ. Sci., 2026, 19,4006-4015
DOI: 10.1039/D5EE07792C, Paper
Wanli Li, Yuheng Li, Arnauld Robert Tapa, Minqiang Liu, Tie Liu, Haibing Xie, Yang Bai, Xiong Li, Zhongqin Xiao, Tao Yu, Zaiwei Wang, Chunxiong Bao, Zhigang Zou
A multifunctional zwitterionic additive regulates crystallization, passivates defects, suppresses ion migration and relaxes residual stress in inverted perovskite solar cells, achieving 26.69% certified efficiency and excellent stability.
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Queen cell architecture shapes honey bee queen development

Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10534-3

Worker bee construction behaviour actively engineers a physicochemical niche that is crucial for queen development in honey bees.

Precipitation threshold-driven shifts in dominant controls of ecosystem nitrogen retention

Nature Geoscience, Published online: 25 May 2026; doi:10.1038/s41561-026-01992-5

The dominant control of soil nitrogen retention changes at a threshold of around 700 mm precipitation, according to an analysis of soil nitrogen and biogeochemical measurements from 31 sites across the United States.
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