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Normal view

Modular in vivo antibody–ADC click to reverse drug resistance in tumours

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10789-w

In vivo ligation of clinically used therapeutic antibodies via bioorthogonal click chemistry to antibody–drug conjugates leads to enhanced antitumour activity in heterogeneous and treatment-resistant tumours.

Spatial distribution of the proteome in the human body and in cancers

Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10660-y

A spatially resolved map of the human proteome across a variety of healthy tissues and cancers provides wide-ranging insights in developmental biology and oncology, and could aid the identification of therapeutic targets and development of treatments for cancer.
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