A new approach that changes just one atom in plastic-degrading enzymes could help make them more efficient while maintaining their stability, according to new research from The Australian National University published in Angewandte Chemie International Edition.

A square peg doesn't fit a round hole. But what if the peg could change the shape of the hole? A newly developed drug molecule can do something surprisingly similar when binding to its target protein, according to a University at Buffalo-led study published Tuesday (Sept. 15) in Angewandte Chemie International Edition.

A square peg doesn't fit a round hole. But what if the peg could change the shape of the hole? A newly developed drug molecule can do something surprisingly similar when binding to its target protein, according to a University at Buffalo-led study published Tuesday (Sept. 15) in Angewandte Chemie International Edition.

The development of cooking was a major milestone in the evolution of human civilization because it made food easier to digest and more energy-efficient. Heating food can also kill harmful pathogens and make certain foods taste better. Overcooking, on the other hand, can have adverse effects, particularly on proteins.

The biopolymer lignin—one of the most important carbon reservoirs in plants and soils—not only decays through fungi or bacteria but can also be chemically attacked by iron linked to reactive oxygen species, without the involvement of microorganisms. When this happens, lignin is converted into methanol and subsequently into formaldehyde. That is shown by a study conducted at Heidelberg University's Institute of Earth Sciences.

Ancient teeth suggest humans were using psychoactive betel nuts 25,000 years ago, pushing the history of habitual drug use deep into the Ice Age. Archaeologists from Griffith University have found evidence suggesting that humans were using mind-altering substances far earlier than previously believed. The research team, led by Professor Adam Brumm of Griffith’s Australian Research [...]

For more than a century, pharmaceutical companies have relied on flat structures called aromatic rings, which can help drugs bind to target sites in the body. They include benzene rings and other flat, nitrogen-containing rings. But there are limits to their usefulness.

For more than a century, pharmaceutical companies have relied on flat structures called aromatic rings, which can help drugs bind to target sites in the body. They include benzene rings and other flat, nitrogen-containing rings. But there are limits to their usefulness.

Life in the deep sea is under immense pressure—literally. Such extreme conditions can disrupt the delicate structures of proteins essential to life. Yet somehow, the proteins in deep-sea creatures remain functional. This raises an intriguing question: how?

Life in the deep sea is under immense pressure—literally. Such extreme conditions can disrupt the delicate structures of proteins essential to life. Yet somehow, the proteins in deep-sea creatures remain functional. This raises an intriguing question: how?

Lipid droplets in the kidneys may help cats maintain a consistent chemical “scent identity.” Scent marks can linger long after an animal has moved on, allowing urine and other chemical signals to carry information across both distance and time. Yet the molecules responsible for odor do not remain unchanged. They evaporate, break down, and shift [...]

Researchers from the Singapore-MIT Alliance for Research & Technology's (SMART) Antimicrobial Resistance (AMR) interdisciplinary research group, alongside collaborators from Massachusetts Institute of Technology (MIT), Nanyang Technological University (NTU Singapore), and institutions in the United States, Poland and France, have discovered aminovaleramididine synthetase (AvaS), the first identified pyridoxal phosphate (PLP)-dependent enzyme responsible for producing a chemical modification linked to how bacteria respond to metabolic stress.

Growth of the ID movement has occurred through “sowing the seeds” of evidential support for the theory.

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Researchers from the Manchester Institute of Biotechnology, including Dr. Zachary Birch-Price and professor Anthony Green, have developed a new family of engineered enzymes that can create several different types of chemical bonds used to build complex molecules. This work demonstrates how artificial enzymes can be adapted to carry out a broad range of carbon-carbon (C-C) and carbon-nitrogen (C-N) bond-forming reactions with high selectivity, offering new possibilities for biocatalysis.

Researchers from the Manchester Institute of Biotechnology, including Dr. Zachary Birch-Price and professor Anthony Green, have developed a new family of engineered enzymes that can create several different types of chemical bonds used to build complex molecules. This work demonstrates how artificial enzymes can be adapted to carry out a broad range of carbon-carbon (C-C) and carbon-nitrogen (C-N) bond-forming reactions with high selectivity, offering new possibilities for biocatalysis.

Third Way and EES thinking shows that mainstream science is moving on a compass heading that is right in the direction of intelligent design.

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It makes sense to think that the T3SS didn’t evolve into the bacterial flagellum, but that the bacterial flagellum shed some protein parts to become a T3SS. 

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A worker at a US government lab got bitten by a monkey carrying a deadly virus, and it turned out nobody knew what to do about it. Around the same time, someone from the same lab tried to smuggle outbreak samples into the country. All of this while everyone's worried about AI making bioweapons. Let's take a look.

The cover artist was working on a bit of extra creativity, showing Behe playing poker with Charles Darwin, and holding the winning cards.

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