A hidden molecular defect in inflammatory bowel disease may help explain why flare-ups can return even when patients appear well. Even when inflammatory bowel disease appears under control, intestinal cells may remain primed to die. In a WEHI-led study, researchers found this hidden molecular defect in patients with few or no symptoms, and higher levels [...]

Many things change in space, including how the intestines function. Constipation is a known side effect of space travel, but until now, little has been known about why it happens. Constipation is a familiar problem for astronauts, but the biological reason it develops during spaceflight has remained uncertain. Researchers from the University of Copenhagen working [...]

Scientists identified an autoimmune mechanism linked to a major IBD risk gene, opening the door to targeted diagnosis and personalized therapies for thousands of patients. For decades, inflammatory bowel disease (IBD) has been treated as a single disorder, even though patients often experience dramatically different symptoms, disease courses, and responses to therapy. A new study [...]

Scientists restored young gut bacteria in aging mice and saw signs of rejuvenation along with complete protection from liver cancer. Returning the gut microbiome to a more youthful state could help slow aging and lower the risk of liver cancer, according to research entitled “Restoration of a youthful gut microbiome reduces liver aging and suppresses [...]