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Normal view

Multimodal precision diagnostics in clinical xenotransplantation

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11096-0

Now that hyperacute rejection of pig xenografts can be reliably prevented, subtler immune-mediated graft injuries have emerged that conventional diagnostics often miss; a multimodal precision diagnostic framework is proposed to detect these injuries earlier, guide personalized immunosuppression and inform future gene editing strategies.

The contribution of salt marshes to wave attenuation during extreme storms

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11145-8

Salt marsh platforms resist erosion under extreme waves, but vegetation damage reduces wave attenuation; substantial wave attenuation by vegetation is mainly limited to low-energy marsh coasts with waves below 1 m.

Zeolite-catalysed olefin carbonylation based on tuning spatial confinement

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11183-2

The use of zeolites with an appropriate pore structure combined with a high CO/olefin ratio is shown to catalyse olefin carbonylation and produce primary and secondary carboxylic acids as the main products.

Cold activates a BH2 metabolic network promoting longevity and proteostasis

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11152-9

A multi-tissue signalling system links cold temperature to enhanced longevity and proteostasis in Caenorhabditis elegans.

WEE1 opposes APC/C<sup>CDH1</sup> activity to promote S phase entry

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11188-x

Experimental and modelling data indicate that WEE1 promotes re-entry of quiescent cells into the cell cycle, potentially explaining the toxic side effects of WEE1 inhibitors in cancer therapies.

An environmentally regulated dichotomy in cell lineages of the root

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11179-y

An environment-regulated state is identified across multiple cell types at the root tip, revealing a shared dichotomy between cells with and without this state.

CD51 delineates functionally distinct astrocyte subtypes in neural circuits

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11186-z

CD51+ astrocytes promote synapse formation in the developing cortex, circuit plasticity in the hippocampus and circuit remodelling after stroke.

Persistent neuronal stress signalling underlies Angelman syndrome phenotypes

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11165-4

Genetic and proteomic analyses in human neurons and mouse models of Angelman syndrome (AS) show that loss of the ubiquitin ligase UBE3A leads to an overabundance of asparagine synthetase, and that this is linked with many AS phenotypes.

GRP75-dependent SIMPA mediates inter-organellar quality control

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-10733-y

Proteotoxic stress drives formation of GRP75-dependent protein aggregates that signal through mitochondria–ER contact sites to activate targeted quality-control pathways, enabling selective clearance of damaged proteins and preserving mitochondrial integrity.

Programmable design of functional proteins from natural language

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11205-z

Pinal, a 16-billion-parameter artificial intelligence model, designs functional proteins from natural-language descriptions, demonstrating experimentally validated activities and improved CO2-fixation product yields without iterative optimization.

Octupole-driven spin torque switching of antiferromagnetic tunnel junctions

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11172-5

All-antiferromagnetic tunnel junctions can display both a large TMR and a reciprocal switching effect, octupole-driven spin-transfer torque, enabling nanoscale magnetic memory and potentially room-temperature terahertz spintronic devices.

The proteome of Middle Pleistocene Xujiayao and common Denisovan morphology

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11132-z

Denisovans from the Xujiayao and other East Asian sites are morphologically distinctive, with a low cranial profile with near-parallel lateral walls, a massive supraorbital torus, a flat zygomaxillary region and weak prognathism.

Functional architecture of the human insula

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11175-2

A functional architecture of the human insula links cytoarchitecture to directed and asymmetric electrophysiological interactions, with mechanistic implications for cognitive modulation of pain and interoceptive experience.

Drought and disease trigger novel interactions among top predators

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11194-z

Climate-driven drought and prey decline triggered lynx predation on raptors, reducing raptor fitness and abundance and producing cascading effects across lower trophic levels.
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