Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11118-x
Highly efficient base editing at PCSK9 and normal human embryo developmentNature, Published online: 09 September 2026; doi:10.1038/d41586-026-02843-4
Evidence suggests that regular calls can keep kids learning when schooling is disrupted — plus, why a familiar world map may be about to change.Nature, Published online: 09 September 2026; doi:10.1038/d41586-026-02751-7
Learn how artificial intelligence can hone your research skills as well as the potential pitfalls of relying too heavily on it.Nature, Published online: 09 September 2026; doi:10.1038/d41586-026-02823-8
Anticancer drugs could be manufactured and delivered by modified microorganisms.Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11025-1
A generative committor-guided path-sampling framework reconstructs rare biomolecular transition pathways and reveals the underlying thermodynamics and kinetics without using predefined collective variables or brute-force sampling, at an acceptable computational cost.Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11039-9
This study uses a within-family design to identify significant ancestry differences in complex traits such as height and type 2 diabetes in a genetically diverse population from Mexico City.Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10876-y
In mice, a sparse population of sleep-active long-range inhibitory neurons in the neocortex promote widespread cortical synchronization and sleep, revealing a cortical mechanism that contributes to the regulation of sleep.Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11001-9
Temporal protein-abundance measurements from systematically perturbed breast cancer cell lines were generated to develop ProteinTalks, a virtual cell model that functions as an operational tool for diverse drug discovery tasks.Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10954-1
A specific population of macrophages that express high levels of the enzyme PLA2G2D in tumour-draining lymph nodes is associated with poor prognosis in patients, and inhibiting PLA2G2D improves anti-tumour immunity in mouse models.Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10968-9
Deep-foam photolithography uses light-controlled polymer foaming to create high-resolution, multifunctional microstructures with tunable optical, wetting and fluid-handling properties for advanced manufacturing applications.Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11004-6
Integrating satellite-derived war-damage data with text-based fatality records through improvement, enrichment and fusion mitigates limitations inherent in each source, revealing complex violence dynamics beyond fatality-centric paradigms, as case studies from Ukraine and Myanmar illustrate.Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10997-4
Evidence from Bianfu Cave shows specialized hunting, expedient stone-tool production and extensive bone use of Denisovans, providing new insights into their ecology, behaviour and cultural legacy in eastern Asia.Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11002-8
SERPINE1 and SERPINB2-driven fibrin-rich niches locally programme immunosuppressive macrophages and exclude T cells, enabling spatially organized immune evasion in pancreatic ductal carcinoma.Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10990-x
Remote phone-based targeted tutoring in five countries produced large, cost-effective learning gains during school closures, outperforming text messaging and working effectively when delivered by governments or non-governmental organizations to strengthen education resilience.Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10976-9
Identification and proteomic analysis of bone fragments and teeth from an excavation in Southwest China provide insight into the evolution and phenotype of Denisovans and fill a geographical gap in their documented distribution.Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11005-5
GPN-Star, a genomic language model with a phylogeny-aware architecture for whole-genome alignment data, is shown to be a scalable and flexible tool for genetic variant effect prediction across species.Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10979-6
An imaging system developed to record cellular activity throughout the whole body of zebrafish captures cellular organ dynamics and identifies multiple distributed circuits.Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10998-3
TRI-611 induces the degradation of ALK fusion proteins via a previously undescribed CRBN recruitment motif, and its preclinical anti-tumour activity highlights TRI-611 as a potential new way of treating ALK-positive non-small-cell lung cancer.Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11008-2
An electrochemical cell with molten hydroxide and a Pd membrane actively extracts H2 and thereby boosts ammonia and methylcyclohexane conversion, while also delivering purified H2 ready for use.Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10468-w
Eight integrated mutational footprints collectively explain the mutational processes in 85% of primary prostate cancer genomes.
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