Nature, Published online: 30 July 2026; doi:10.1038/s41586-026-10939-0

Somatic mutations reveal the ontogeny of microglia in human aging

Nature, Published online: 29 July 2026; doi:10.1038/s41586-026-10791-2

In senescent cells, mitochondria-derived acetyl-CoA promotes histone acetylation and increases chromatin accessibility at inflammatory gene loci. Inhibition of SLC25A1 attenuates these effects, underscoring the therapeutic potential of targeting mitochondrial metabolism and its epigenetic crosstalk to delay age-related functional decline.

Nature, Published online: 29 July 2026; doi:10.1038/s41586-026-10839-3

Perpendicular switching of the polarization state in the layered ferroelectric Bi4Ti3O12 is demonstrated by means of trilinear coupling, allowing manipulation of the in-plane polarization component with an out-of-plane electric field.

Nature, Published online: 29 July 2026; doi:10.1038/s41586-026-10834-8

Pathways to previously undescribed polyenes, including unusual enzymes that introduce more sugars onto polyene scaffolds, are discovered, and their accessibility through clean and efficient fermentation and potential for safe use as antifungal treatments is described.

Nature, Published online: 29 July 2026; doi:10.1038/s41586-026-10754-7

A silicon quantum processing unit executes high-fidelity multiqubit circuits, with all time-varying control signals generated by a digitally programmed cryogenic complementary metal–oxide–semiconductor controller and delivered to the low-noise, exchange-only qubit device through a high-density superconducting ribbon cable.

Nature, Published online: 29 July 2026; doi:10.1038/s41586-026-10841-9

Complete sequencing of more than 2,000 centromeres from diverse humans reveals structures and elevated mutation rates that shape the evolution of these critically important regions.

Nature, Published online: 29 July 2026; doi:10.1038/s41586-026-10835-7

Using canopy-penetrating LiDAR data, the northern part of southwestern Amazonia appears to contain as many earthworks as previously estimated for the whole of Amazonia.

Nature, Published online: 29 July 2026; doi:10.1038/s41586-026-10842-8

Probabilistic sequence encoding from language model embeddings within a generative AI framework enables protein miniaturization, modification and augmentation while maintaining native architecture and functional integrity.

Nature, Published online: 29 July 2026; doi:10.1038/d41586-026-02128-w

In the fly gut, stem cells keep the balance of cell types by undergoing eight rounds of cell division to form absorptive cells, then one round to form secretory cells.