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Normal view

A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome

Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10589-2

Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of the bacterial large ribosomal subunit.

Mining triggers extensive additional deforestation in sub-Saharan Africa

Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10551-2

Extensive mining activity leads to large-scale deforestation of dense tropical forests across sub-Saharan Africa, driven particularly by key energy transition minerals such as cobalt.

Cold-induced peptide signalling secures pollen resilience and crop yield

Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10603-7

A small-peptide signalling axis involving RGF family members controls resilience to cold stress in tomatoes and rice; modulating this pathway prevents cold-induced yield losses.

Teosinte alleles enhance nitrogen assimilation and seed protein in maize

Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10575-8

Teosinte alleles enhance nitrogen assimilation and seed protein without lowering crop yield when expressed in modern maize, providing a powerful strategy for crop improvement to meet future population demands.

Cell-type-resolved genetic variation shapes inflammatory bowel disease risk

Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10627-z

Single-cell mapping of cis-expression quantitative trait loci in inflammatory bowel disease revealed distal, enhancer-enriched variants detected at the cell-type level more frequently co-localize with genome-wide association study loci than those identified at the tissue level.

Plastoglobules compartmentalize nitrogen assimilation in maize

Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10610-8

Chloroplast plastoglobules act as nitrogen-assimilation hubs in maize, with key enzymes enhancing nitrogen-use efficiency and offering new strategies for developing high-yield, sustainable crops.

Analysis of trade-offs of post-sorting plastic packaging

Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10606-4

An analysis of post-sorting plastic packaging shows that target polymer purity is similar across source-separation and post-sorting pathways, but post-sorted plastics contain more contaminants that need to be removed before recyclate production.

Spermine is an endogenous iron chelator that inhibits ferroptosis

Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10597-2

A non-canonical metabolic route for spermine synthesis mediated by ALDH18A1 limits iron availability and lipid peroxidation in hepatocellular carcinoma.

Mechanophore cross-linking enhances ballistic energy dissipation of polymers

Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10557-w

Embedding a small fraction of force-sensitive mechanophores as cross-links into common polymers enhances ballistic energy dissipation.

Commensal-derived acetylcholine enhances mucosal immune education

Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10592-7

A diet–microbiome–host axis strengthens mucosal immune defences and reinforces host–microbiota mutualism.

Nuclear shell structure governs short-range nucleon pairing

Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10616-2

The scattering of high-energy electrons from three different nuclei demonstrated that short-range-correlated pairing depends far more on the specific quantum orbitals occupied by nucleons than predicted by theoretical models.

LASER couples damage sensing to ESCRT assembly for lysosome repair

Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10604-6

ATG8 conjugation on damaged lysosomes triggers rapid assembly of a protein complex containing TFG, which directs lysosomal membrane repair by recruiting ESCRT proteins to sites of damage.

Enamel nanocrystal misorientation increased with meat-eating and agriculture

Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10583-8

An analysis of enamel nanocrystal misorientation in primate and human teeth across three major dietary shifts in human evolution shows that misorientation increased with harder diets, suggesting that misorientation contributes to enamel’s resilience.

High-fidelity modular skeletons authenticate a Cambrian origin for Bryozoa

Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10590-9

Exquisite early Cambrian fossils of Protomelission gatehousei and Dayingomelission hexaclitia preserve soft-tissue anatomy and skeletal microstructure, confirming that these taxa are definitively bryozoans and indicating a deeper origin for the Bryozoa than was first apparent.
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