Nature, Published online: 10 September 2026; doi:10.1038/s41586-026-11079-1

Author Correction: The molecular basis of force selectivity by PIEZO2

Nature, Published online: 09 September 2026; doi:10.1038/d41586-026-02598-y

Changes to the Open Science Framework’s policies will come into effect in November, forcing researchers to reconsider their workflows.

Nature, Published online: 09 September 2026; doi:10.1038/d41586-026-02867-w

The AI giant claims to have solved one of maths’ trickiest problems, but questions swirl over should get the credit. Plus, an atlas of every single DNA letter mutation in humans and why more bioengineered microorganisms aren’t making it out of the lab.

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11118-x

Highly efficient base editing at PCSK9 and normal human embryo development

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11025-1

A generative committor-guided path-sampling framework reconstructs rare biomolecular transition pathways and reveals the underlying thermodynamics and kinetics without using predefined collective variables or brute-force sampling, at an acceptable computational cost.

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11039-9

This study uses a within-family design to identify significant ancestry differences in complex traits such as height and type 2 diabetes in a genetically diverse population from Mexico City.

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10876-y

In mice, a sparse population of sleep-active long-range inhibitory neurons in the neocortex promote widespread cortical synchronization and sleep, revealing a cortical mechanism that contributes to the regulation of sleep.

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11001-9

Temporal protein-abundance measurements from systematically perturbed breast cancer cell lines were generated to develop ProteinTalks, a virtual cell model that functions as an operational tool for diverse drug discovery tasks.

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10954-1

A specific population of macrophages that express high levels of the enzyme PLA2G2D in tumour-draining lymph nodes is associated with poor prognosis in patients, and inhibiting PLA2G2D improves anti-tumour immunity in mouse models.

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10968-9

Deep-foam photolithography uses light-controlled polymer foaming to create high-resolution, multifunctional microstructures with tunable optical, wetting and fluid-handling properties for advanced manufacturing applications.

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11004-6

Integrating satellite-derived war-damage data with text-based fatality records through improvement, enrichment and fusion mitigates limitations inherent in each source, revealing complex violence dynamics beyond fatality-centric paradigms, as case studies from Ukraine and Myanmar illustrate.

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10997-4

Evidence from Bianfu Cave shows specialized hunting, expedient stone-tool production and extensive bone use of Denisovans, providing new insights into their ecology, behaviour and cultural legacy in eastern Asia.

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11002-8

SERPINE1 and SERPINB2-driven fibrin-rich niches locally programme immunosuppressive macrophages and exclude T cells, enabling spatially organized immune evasion in pancreatic ductal carcinoma.

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10990-x

Remote phone-based targeted tutoring in five countries produced large, cost-effective learning gains during school closures, outperforming text messaging and working effectively when delivered by governments or non-governmental organizations to strengthen education resilience.

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10976-9

Identification and proteomic analysis of bone fragments and teeth from an excavation in Southwest China provide insight into the evolution and phenotype of Denisovans and fill a geographical gap in their documented distribution.

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11005-5

GPN-Star, a genomic language model with a phylogeny-aware architecture for whole-genome alignment data, is shown to be a scalable and flexible tool for genetic variant effect prediction across species.

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10979-6

An imaging system developed to record cellular activity throughout the whole body of zebrafish captures cellular organ dynamics and identifies multiple distributed circuits.

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10998-3

TRI-611 induces the degradation of ALK fusion proteins via a previously undescribed CRBN recruitment motif, and its preclinical anti-tumour activity highlights TRI-611 as a potential new way of treating ALK-positive non-small-cell lung cancer.

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11008-2

An electrochemical cell with molten hydroxide and a Pd membrane actively extracts H2 and thereby boosts ammonia and methylcyclohexane conversion, while also delivering purified H2 ready for use.

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10468-w

Eight integrated mutational footprints collectively explain the mutational processes in 85% of primary prostate cancer genomes.