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Within-family effect of ancestry on complex traits in a Mexican population

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11039-9

This study uses a within-family design to identify significant ancestry differences in complex traits such as height and type 2 diabetes in a genetically diverse population from Mexico City.

Neocortical long-range inhibition promotes cortical synchrony and sleep

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10876-y

In mice, a sparse population of sleep-active long-range inhibitory neurons in the neocortex promote widespread cortical synchronization and sleep, revealing a cortical mechanism that contributes to the regulation of sleep.

PLA2G2D in tumour-draining lymph nodes regulates anti-tumour immunity

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10954-1

A specific population of macrophages that express high levels of the enzyme PLA2G2D in tumour-draining lymph nodes is associated with poor prognosis in patients, and inhibiting PLA2G2D improves anti-tumour immunity in mouse models.

Advancing conflict research and response through satellite-derived data

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11004-6

Integrating satellite-derived war-damage data with text-based fatality records through improvement, enrichment and fusion mitigates limitations inherent in each source, revealing complex violence dynamics beyond fatality-centric paradigms, as case studies from Ukraine and Myanmar illustrate.

TM184C is a GPCR-like regulator of intercellular exchange and autophagy

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10993-8

TM184C—an ancient G-protein-coupled receptor-like superdark protein involved in regulation of autophagy, intercellular connectivity and material exchange—underscores the promise of exploring the understudied human proteome and beyond.

Proximity-guided graph learning reveals tumour-associated proximity antigens

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11003-7

A proximity-mapping atlas defines tumour-associated proximity antigens, revealing disease-associated membrane spatial communities, and identifies EGFR–CDCP1 as a co-target pair that enhances tumour killing by multispecific therapeutics.

Why environmental treaties must also address mental health

Nature, Published online: 10 August 2026; doi:10.1038/d41586-026-02450-3

Global conventions have mainly overlooked the psychological and social impacts of climate change, biodiversity loss and pollution. Here’s how to change that.

A dependency map enhanced with next-generation 3D cancer models

Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10843-7

Integration of genome-scale CRISPR screening data from traditional cell lines and next-generation cancer models expands the representation of tumour subtypes and genomic alterations in The Cancer Dependency Map.

Upcycling of polyvinyl chloride into polyalphaolefin lubricants

Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10867-z

A mild chemical process upcycles polyvinyl chloride waste into polyalphaolefin lubricants with tunable properties, offering an economical route to plastic recycling and improved carbon circularity.

An entangling gate for dual-rail erasure qubits

Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10822-y

A fast, low-error entangling gate for dual-rail cavity erasure qubits preserves a strong error hierarchy, advancing scalable quantum error correction with substantially improved fault-tolerant performance.
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