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Why environmental treaties must also address mental health

Nature, Published online: 10 August 2026; doi:10.1038/d41586-026-02450-3

Global conventions have mainly overlooked the psychological and social impacts of climate change, biodiversity loss and pollution. Here’s how to change that.

A dependency map enhanced with next-generation 3D cancer models

Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10843-7

Integration of genome-scale CRISPR screening data from traditional cell lines and next-generation cancer models expands the representation of tumour subtypes and genomic alterations in The Cancer Dependency Map.

Upcycling of polyvinyl chloride into polyalphaolefin lubricants

Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10867-z

A mild chemical process upcycles polyvinyl chloride waste into polyalphaolefin lubricants with tunable properties, offering an economical route to plastic recycling and improved carbon circularity.

An entangling gate for dual-rail erasure qubits

Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10822-y

A fast, low-error entangling gate for dual-rail cavity erasure qubits preserves a strong error hierarchy, advancing scalable quantum error correction with substantially improved fault-tolerant performance.

Encapsulation epitaxy of air-stable 2D superconductors for quantum circuits

Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10865-1

An ‘encapsulation epitaxy’ mechanism is used to grow air-stable, two-dimensional superconducting films at the interface of a 2D–3D hybrid substrate, holding promise for use in fabrication of superconducting quantum circuitry.

A compendium of next-generation patient-derived models for diverse cancers

Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10806-y

The international collaboration of the Human Cancer Models Initiative presents a comprehensive resource of next-generation cancer models from 2,780 donors with 25 cancer types and integrated tumour–model genomic, transcriptomic and epigenomic analyses.

The Virtual Tissues foundation model resolves spatial proteomics across scales

Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10884-y

Virtual Tissues (VirTues), a foundation model for spatial proteomics that captures tissue organization across scales, supports marker reconstruction, cell segmentation and typing, niche annotation, spatial biomarker discovery and patient stratification across heterogeneous panels and datasets.

Virus reactivation in acute and long COVID-19

Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10740-z

Chronic reactivation of distinct herpesviruses and anelloviruses occur during acute and long COVID-19, and track with disease severity, inflammation and outcomes, revealing immune signatures with prognostic potential.

Uncovering the mechanism of female restitution in sugarcane hybrids

Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10863-3

Female restitution in interspecific sugarcane hybrids between Saccharum officinarum and Saccharum spontaneum arises from second division restitution, as haplotype-resolved F1 genomes reveal duplicated, partially recombined maternal chromatids and distinctive recombination signatures, resolving its meiotic mechanism and enabling breeding strategies to accelerate crop improvement.

A tumour-derived organoid biobank maps cancer gene dependencies

Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10830-y

A clinically annotated multi-omic organoid resource with matched tumour samples from 256 patients across 5 cancers maps gene dependencies, reveals subtype-specific vulnerabilities and uncovers treatment-driven changes, expanding mechanistic insight and models for precision oncology.

DCAF11-dependent molecular glue degrader activated by glutathionylation

Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10873-1

M12 is a metabolically activated molecular glue that recruits diverse proteins to DCAF11 for ubiquitin-mediated degradation, revealing a glutathione-dependent mechanism that broadens targeted protein degradation across multiple substrates.
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