Nature, Published online: 30 July 2026; doi:10.1038/s41586-026-10939-0

Somatic mutations reveal the ontogeny of microglia in human aging

Nature, Published online: 29 July 2026; doi:10.1038/s41586-026-10791-2

In senescent cells, mitochondria-derived acetyl-CoA promotes histone acetylation and increases chromatin accessibility at inflammatory gene loci. Inhibition of SLC25A1 attenuates these effects, underscoring the therapeutic potential of targeting mitochondrial metabolism and its epigenetic crosstalk to delay age-related functional decline.

Nature, Published online: 29 July 2026; doi:10.1038/s41586-026-10839-3

Perpendicular switching of the polarization state in the layered ferroelectric Bi4Ti3O12 is demonstrated by means of trilinear coupling, allowing manipulation of the in-plane polarization component with an out-of-plane electric field.

Nature, Published online: 29 July 2026; doi:10.1038/s41586-026-10834-8

Pathways to previously undescribed polyenes, including unusual enzymes that introduce more sugars onto polyene scaffolds, are discovered, and their accessibility through clean and efficient fermentation and potential for safe use as antifungal treatments is described.

Nature, Published online: 29 July 2026; doi:10.1038/s41586-026-10754-7

A silicon quantum processing unit executes high-fidelity multiqubit circuits, with all time-varying control signals generated by a digitally programmed cryogenic complementary metal–oxide–semiconductor controller and delivered to the low-noise, exchange-only qubit device through a high-density superconducting ribbon cable.

Nature, Published online: 29 July 2026; doi:10.1038/s41586-026-10841-9

Complete sequencing of more than 2,000 centromeres from diverse humans reveals structures and elevated mutation rates that shape the evolution of these critically important regions.

Nature, Published online: 29 July 2026; doi:10.1038/s41586-026-10835-7

Using canopy-penetrating LiDAR data, the northern part of southwestern Amazonia appears to contain as many earthworks as previously estimated for the whole of Amazonia.

Nature, Published online: 29 July 2026; doi:10.1038/s41586-026-10842-8

Probabilistic sequence encoding from language model embeddings within a generative AI framework enables protein miniaturization, modification and augmentation while maintaining native architecture and functional integrity.

Nature, Published online: 29 July 2026; doi:10.1038/d41586-026-02128-w

In the fly gut, stem cells keep the balance of cell types by undergoing eight rounds of cell division to form absorptive cells, then one round to form secretory cells.

Nature, Published online: 23 July 2026; doi:10.1038/d41586-026-02275-0

From intelligent ships to clues about eclipses, Homer’s The Odyssey reveals how Bronze Age Greeks understood the world.

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10803-1

Chemotherapy, particularly with platinum-based drugs, is associated with substantial, rapidly detectable mutagenesis in childhood cancers, tripling private signatures and doubling mutation burden, highlighting therapy-induced tumour evolution and opportunities for safer, de-escalated treatment.

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10831-x

Cryo-electron microscopy sheds light on the architecture of the Trypanosoma brucei mitochondrial editosome and reveals how this assembly mediates mRNA editing through the insertion and deletion of uridine nucleotides.

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10751-w

Radial velocity measurements provide evidence for a Jupiter-mass exosatellite orbiting the brown dwarf companion CD-35 2722 B, a promising detection of an exomoon-like object.

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10820-0

A workflow using artificial intelligence-redesigned starting points to evolve enzymes with improved properties compared with those evolved from natural proteins is established.

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10828-6

Whole-genome sequencing analysis of tumour and matched non-tumour host tissues of the brown bullhead catfish reveals a type of naturally occurring transmissible cancer.

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10739-6

Using the Global Burden of Disease Study data across Asian countries and territories, life expectancy trends and the effects of cause-specific mortality and risk factors on changes in these trends are analysed.

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10821-z

Experimentally replaying tumour evolution in divergent mouse strains reveals the importance of interactions between genetic ancestry and acquired cancer-driving mutations in shaping the earliest stages of cancer development.

Nature, Published online: 20 July 2026; doi:10.1038/d41586-026-02231-y

Anticipating from the start the various ways a research programme can succeed or fail can avoid problems later. Here’s how to do it.

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10897-7

Selectivity Emerges from Indiscriminate Photoreduction

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10789-w

In vivo ligation of clinically used therapeutic antibodies via bioorthogonal click chemistry to antibody–drug conjugates leads to enhanced antitumour activity in heterogeneous and treatment-resistant tumours.